.... S6 ). Finally, our analysis of Foxi3-CreER null mutant cells shows that the fate restriction of Foxi3-expressing progenitors to placodes and epidermis is dependent on the function of Foxi3 itself. In the absence of Foxi3, these progenitors now adopt a wider range of fates at the neural plate border...

... chimera MyoD Myf5 Pax3 Myogenesis Skeletal muscle Fate restriction Limb Surgical experiments in avian embryos have demonstrated that the presence of skeletal muscle cells in limb primordia results from the morphogenetic movement of an established cell lineage from the somites, rather than...

... a mixture of ascending and descending and/or ipsilateral and contralateral projections ( n =20/132). The former group of clones are evidence that the developmental state of a few precursors remains labile despite the apparent fate-restriction of many of their neighbours, and the second group suggests...