... (radius and ulna of the forearm, tibia and fibula of the leg) are not well understood, although these bones are susceptible to loss in congenital human syndromes and to the action of teratogens such as thalidomide. Using a new fate-mapping approach with the Chameleon transgenic chicken line, we show...

... of all three germ layers in mice that overcomes the difficulties of conventional single-gene tracing systems in precision lineage tracing. Lineage-tracing system Fate map Germ layer 2A peptide Site-specific recombinase Tissue clearing Specification of the cellular populations...

...Iain Martyn; Eric D. Siggia; Ali H. Brivanlou ABSTRACT Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS...

... that perigonadal fat arises from distinct mesodermal subcompartments in males and females, and that <50% of interscapular brown fat arises from central dermomyotome. Adipocyte Adipose Fate map Lineage tracing Mesoderm National Science Foundation 10.13039/100000001 DGE1122492...

...) and developing brain homeobox 1 (Dbx1). Utilizing simultaneous dual and intersectional fate mapping, we demonstrate that this boundary is precisely formed with minimal overlap between En1 and Dbx1 microdomains, unlike many other boundaries. We show that the En1 microdomain gives rise to dopaminergic (DA) neurons...

...Luisa Sanchez-Arrones; Claudio D. Stern; Paola Bovolenta; Luis Puelles The anterior border of the neural plate, presumed to contain the prospective peripheral portion (roof) of the prospective telencephalon, emerges within a vaguely defined proneural ectodermal region. Fate maps carried out at HH4...

... of the invaginating optic cup. We identify unanticipated movements, particularly of central and peripheral retina, RPE and lens. From cell tracking data, we generate retina, RPE and lens subdomain fate maps, which reveal novel adjacencies that might determine corresponding developmental signaling events. Finally, we...

..., expression patterns of anterior ectoderm genes overlap significantly and correlate with areas of distinct prospective fates but do not define lineages. The fate map delineates a rostral limit to forebrain contribution. However, no early subdivision of the presumptive forebrain territory can be detected...

... -80. Joyner, A. L. and Zervas, M. (2006). Genetic inducible fate mapping in mouse: establishing genetic lineages and defining genetic neuroanatomy in the nervous system. Dev. Dyn. 235 , 2376 -2385. Kataoka, A. and Shimogori, T. (2008). Fgf8 controls regional identity in the developing...

...), diencephalon (3rd ventricle) and dorsomedial telencephalon bilaterally (lateral ventricles). All of these sites lie at or near the embryonic dorsal midline (DM), which acts as a CNS patterning center. We therefore examined DM-CP relationships using normal and Gdf7 (Bmp12)transgenic embryos to fate map...

... to fate map the oral epithelium in chick embryos, we show that the cells that will occupy the epithelium of the distal and the proximal mandible primordium already occupy different spatial locations in the developing head ectoderm prior to the formation of the first pharyngeal arch and neural crest...

... consisting of two tissue layers, the myocardium and endocardium. The cellular and molecular mechanisms responsible for the separation of ventricular and atrial lineages are not well understood. To test models of cardiac chamber specification, we generated a high-resolution fate map of cardiac chamber...

... to deduce the division pattern that leads to the eight-cell stage (data not shown). A summary of the results is shown in Fig. 7 . Fig. 7. Fate map and mirror symmetry of the blastomeres. (A,B) Dorsal view at the eight-cell stage with the macromeres highlighted in A and the micromeres highlighted...

... mosaic Fate map Genetic redundancy Genetic synergy Zebrafish T-box transcription factors are a large family of transcriptional regulators involved in many aspects of embryonic development (Smith, 1999). The founding family member, Brachyury (or T), was originally identified by mutation...

...Alexandria Saulsberry; Paula R. Martin; Tim O’Brien; Leslie E. Sieburth; F. Bryan Pickett Creation of an embryonic fate map may provide insight into the patterns of cell division and specification contributing to the apical region of the early Arabidopsis embryo. A fate map has been constructed...

...Pedro Fernández-Garre; Lucia Rodríguez-Gallardo; Victoria Gallego-Díaz; Ignacio S. Alvarez; Luis Puelles A detailed fate map was obtained for the early chick neural plate (stages 3d/4). Numerous overlapping plug grafts were performed upon New-cultured chick embryos, using fixable...

...). A zebrafish homologue of the Drosophila neurogenic gene Notch and its pattern of transcription during early embryogenesis. Mech. Dev . 43 , 87 -100. Catala, M., Teillet, M. A., de Robertis, E. M. and le Douarin, M. L. (1996). A spinal cord fate map in the avian embryo: while regressing, Hensen’s...

... and whether their migratory properties change during the embryonic development. The ultrasound guided transplantation proves to be a powerful technique to study cell migration in vivo and in the future it should facilitate more extensive fate mapping analysis of the developing mammalian embryo. Hopefully...

...Abhay Redkar; Michael Montgomery; Judith Litvin Cardiogenic fate maps are used to address questions on commitment, differentiation, morphogenesis and organogenesis of the heart. Recently, the accuracy of classical cardiogenic fate maps has been questioned, raising concerns about the conclusions...

.... As the olfactory placode field converges anteriorly, it maintains regionalized cell fates such that cells in the anterior olfactory placode field contribute to the anterior medial part of the olfactory organ and posterior cells form the lateral part of the nose (Fig. 8A,B). Our fate map also shows that cells...