... Summary: Astrocyte-intrinsic and -extrinsic activities of the Fat1 cadherin influence astrocyte migration polarity, proliferation and maturation. Their disruption impacts retinal vascular development and maintenance. Angiogenesis Astrocytes Fat cadherins Retina Planar polarized migration...

... in the neural tube. Fat cadherins Mammalian cortex development Apical constriction Brain Neural tube defects Radial glial precursor Neural tube closure defects (NTDs) are very common and severe congenital malformations that affect ∼1/1000 pregnancies ( Mitchell, 2005 ). The neural tube forms...

... W. M. , Baumgartner S. ( 2004 ). The fat-like gene of Drosophila is the true orthologue of vertebrate fat cadherins and is involved in the formation of tubular organs . J. Biol. Chem. 279 , 24034 – 24043 . Choi M. , Klingensmith J. ( 2009 ). Chordin is a modifier...