...Bipin Kumar Tripathi; Kenneth D. Irvine ABSTRACT The protocadherins Fat and Dachsous regulate organ growth, shape, patterning, and planar cell polarity. Although Dachsous and Fat have been described as ligand and receptor, respectively, in a signal transduction pathway, there is also evidence...

... localised within each cell. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part of a cell becomes different from another part .’       Sydney Brenner (1994) Imagine how tricky it would...

... Fat Kidney Nephron Highlighted article: In mice, kidney morphogenesis and size of the nephron progenitor pool are regulated by Fat4-Dchs1 signaling between stromal cells and nephron progenitors, independently of YAP. © 2015. Published by The Company of Biologists Ltd 2015 28 1...

...Mariana Rodrigues-Campos; Barry J. Thompson The atypical cadherins Dachsous (Ds) and Fat (Ft) are required to control the size and shape of tissues and organs in animals. In Drosophila , a key effector of Ds and Ft is the atypical myosin Dachs, which becomes planar polarised along the proximal...

...Praveer Sharma; Helen McNeill Fat (Ft) and Dachsous (Ds) are large cadherins that bind each other and have conserved roles in regulating planar cell polarity (PCP). We quantitatively analyzed Ft-Ds pathway mutant clones for their effects on ommatidial polarity in the Drosophila eye. Our findings...

...Guohui Pan; Yongqiang Feng; Abhijit A. Ambegaonkar; Gongping Sun; Matthew Huff; Cordelia Rauskolb; Kenneth D. Irvine The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways. Here we investigate the molecular basis for signal transduction downstream...

...Emily Marcinkevicius; Jennifer A. Zallen The atypical cadherin Fat is a conserved regulator of planar cell polarity, but the mechanisms by which Fat controls cell shape and tissue structure are not well understood. Here, we show that Fat is required for the planar polarized organization of actin...

...Hitoshi Matakatsu; Seth S. Blair The giant Drosophila protocadherin Fat (Ft) affects planar cell polarity (PCP). Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the activity of the transcription co-factor Yorkie (Yki). Much of Ft activity is likely to be mediated...

... ; [email protected] ) Competing interests statement The authors declare no competing financial interests. 31 8 2011 © 2011. FIRE Adipogenesis ETS2 Fat In vivo Mouse In mammals, white adipose tissue (WAT) functions both as a depot for the storage of lipid...

... receptor Fat (Ft) are enriched in distinct patterns in the epithelium during embryonic development. If, however, the Ds system operates independently of the Fz system, this would have significant ramifications for our understanding of the molecular mechanisms that must be engaged downstream of each...

...Yaopan Mao; Joanna Mulvaney; Sana Zakaria; Tian Yu; Katherine Malanga Morgan; Steve Allen; M. Albert Basson; Philippa Francis-West; Kenneth D. Irvine The Drosophila Dachsous and Fat proteins function as ligand and receptor, respectively, for an intercellular signaling pathway that regulates Hippo...

...Ada Repiso; Pedro Saavedra; José Casal; Peter A. Lawrence The larval ventral belts of Drosophila consist of six to seven rows of denticles that are oriented, some pointing forwards, some backwards. We present evidence that denticle orientation is determined almost entirely by Dachsous and Fat, one...

...B. V. V. G. Reddy; Cordelia Rauskolb; Kenneth D. Irvine The Drosophila optic lobe develops from neuroepithelial cells, which function as symmetrically dividing neural progenitors. We describe here a role for the Fat-Hippo pathway in controlling the growth and differentiation of Drosophila optic...

...Yaopan Mao; Binnaz Kucuk; Kenneth D. Irvine The Fat-Hippo-Warts signaling network regulates both transcription and planar cell polarity. Despite its crucial importance to the normal control of growth and planar polarity, we have only a limited understanding of the mechanisms that regulate Fat. We...

...Hyangyee Oh; Kenneth D. Irvine Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase. Here, we use Phos-tag gels to characterize Warts-dependent phosphorylation of Yki in vivo, and show that Warts promotes phosphorylation of Yki...

...José Casal; Peter A. Lawrence; Gary Struhl Planar polarity is a fundamental property of epithelia in animals and plants. In Drosophila it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed...

... of strong dachs mutations, report the cloning of the dachs gene, characterize the localization of Dachs protein, and investigate the relationship between Dachs and the Fat pathway. Mutation of dachs reduces, but does not abolish, the growth of legs and wings. dachs encodes an unconventional myosin...

... the dorsoventral (DV) organizer in distal wing, suggesting a PD gradient of cell-cell adhesion. The Fat (Ft)tumor suppressor, by contrast, represses DE-Cad expression. In genetic tests, ft behaves as a suppressor of Wg signaling. Cytoplasmic pool of β-catenin/Arm, the intracellular transducer of Wg signaling...

...Eunjoo Cho; Kenneth D. Irvine In the Drosophila wing, distal cells signal to proximal cells to induce the expression of Wingless, but the basis for this distal-to-proximal signaling is unknown. Here, we show that three genes that act together during the establishment of tissue polarity, fat , four...

...Manolis Fanto; Lesley Clayton; Jamie Meredith; Kirsten Hardiman; Bernard Charroux; Stephen Kerridge; Helen McNeill Fat is an atypical cadherin that controls both cell growth and planar polarity. Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known...