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Journal Articles

FRL-1 , a member of the EGF-CFC family, is essential for neural differentiation in Xenopus early development

Shin-Ichiro Yabe, Kousuke Tanegashima, Yoshikazu Haramoto, Shuji Takahashi, Tomoyuki Fujii, Siro Kozuma, Yuji Taketani, Makoto Asashima
Journal: Development
Development (2003) 130 (10): 2071–2081.
https://doi.org/10.1242/dev.00430
Published: 15 May 2003
... suggests that EGF-CFC genes can also activate certain cellular responses independently of nodal signaling. Here, we show that FRL-1 , a Xenopus EGF-CFC gene, suppresses BMP signaling to regulate an early step in neural induction. Overexpression of FRL-1 in animal caps induced the early neural markers zic3...
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