... (AMPK)–forkhead box O subfamily (FoxO) axis. Impairment of the FoxO-mediated Hpd induction in the epidermis leads to aberrant increases in internal Tyr and its metabolites, disrupting larval development on high-protein diets. Taken together, our findings uncover a crucial role of the epidermis...

... synthesis required for the maturation of multiple oocytes, but the underlying mechanisms remain poorly understood. Using the migratory locust Locusta migratoria as a model system, we report here that JH induces the dephosphorylation of Forkhead box O transcription factor (FoxO) through a signaling cascade...

... CXCL12-dependent cell migration and proliferation in lymphatic endothelium. FOXO C-X-C chemokine receptor type 4 (CXCR-4) Lymphangiogenesis C-X-C chemokine ligand 12 (CXCL-12) Tail dermis Chemokine Japan Society for the Promotion of Science 10.13039/501100001691 15K08142 16K08442...

... of actin extensions and migration through the egg chamber. In this process, the transcription factor FoxO acts as a repressor of chickadee expression. Altogether, these results show that local activation of IIS controls collective cell migration through regulation of actin homeostasis and protrusion...

... and Bargmann, 2005 ; Foldi et al., 2017 ; Gay and Gangloff, 2007 ; Wu et al., 2015 ). In addition, alternative signalling pathways are being discovered, for instance those involving FoxO or cell-to-cell communication ( Chuang and Bargmann, 2005 ; Foldi et al., 2017 ; McLaughlin et al., 2016 ; Paré et al...

... mutants requires DPY-21, SET-4 and the FoxO transcription factor DAF-16, which is the main target of DAF-2 ILS. By contrast, autosomal genes encoding major agonist ILPs that promote reproductive development are not repressed by DPY-21, SET-4 or DAF-16/FoxO. Our results implicate SET-4 as a sensory...

... is the lipid phosphatase DAF-18/PTEN, which can modulate PI3K pathway activity during neurodevelopment. Here, we identify a novel role for DAF-18 in promoting neurite outgrowth during development in Caenorhabditis elegans . We find that DAF-18 modulates the PI3K signaling pathway to activate DAF-16/FOXO...

... the entire body, most likely by regulating feeding behavior. In muscles, InR/Tor signaling, Foxo and dMyc(Diminutive) are key regulators of endoreplication, which is necessary but not sufficient to induce growth. Mechanistically, InR/Foxo signaling controls cell cycle progression by modulating dmyc...