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Keywords: FGFR1
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Journal Articles
Journal: Development
Development (2008) 135 (2): 281–290.
Published: 15 January 2008
... identified headfish ( hdf ), a null mutant for fgf receptor 1 ( fgfr1 ),which fails to develop structures in the trunk and tail. Despite its crucial role in early development, the functions of Fgfr1-mediated signaling have not yet been well characterized due to the complexity of the underlying ligand...
Journal Articles
Journal: Development
Development (2008) 135 (2): 353–365.
Published: 15 January 2008
... ectopically throughout most of the ectoderm. Inhibition of either FGFA, FGFR1 or FGFR2 function severely affects morphogenesis of the skeleton. Furthermore,inhibition of FGFA and FGFR1 signaling dramatically delays invagination of the archenteron, prevents regionalization of the gut and abrogates formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 663–673.
Published: 15 February 2006
...Renée V. Hoch; Philippe Soriano Fibroblast growth factor receptor 1 ( Fgfr1 ) plays pleiotropic roles during embryonic development, but the mechanisms by which this receptor signals in vivo have not previously been elucidated. Biochemical studies have implicated Fgf receptor-specific substrates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (19): 4559–4569.
Published: 1 October 2002
... myogenesis. We examined FGFR4 function during myogenesis, and we demonstrate that inhibition of FGFR4, but not FGFR1 signaling, leads to a dramatic loss of limb muscles. All muscle markers analyzed (such as Myf5, MyoD and the embryonic myosin heavy chain) are affected. We show that inhibition of FGFR4 signal...