... give rise to toe-like or wing-like digits in wing and leg respectively. Expression of Tbx-4 is stable when leg tissue is grafted to wing, and Tbx-5 expression is stable when wing tissue is grafted to leg. Induction of either extra wings or legs from the flank by applying FGF-2 in different positions...

...Craig M. Stolen; Mark W. Jackson; Anne E. Griep ABSTRACT During mammalian embryogenesis, the ocular lens forms through a temporally and spatially regulated pattern of differentiation which is thought to be coordinated at least in part by the FGF-1 and FGF-2 members of the fibroblast growth factor...

... added exogenously to the developing Xenopus optic pathway, severely disrupt target recognition causing axons from the retina to bypass their primary target, the optic tectum. Significantly, HS sidechains from a neuro-epithelial perlecan variant that preferentially bind FGF-2, HS(FGF-2), cause aberrant...

...Caroline N. Dealy; Robert A. Kosher ABSTRACT IGF-I, insulin, FGF-2 and FGF-4 have been implicated in the reciprocal interactions between the apical ectodermal ridge (AER) and underlying mesoderm required for outgrowth and patterning of the developing limb. To study further the roles of these growth...

...). These data indicate that duplications need not contain large quantities of donor tissue per se. Instead, proximity to FGF-2-expressing donor cells may be sufficient to induce host tissue to form extra elements. This interpretation is supported by the pattern of ectopic FGF-2 expression seen in younger limbs...

... matrix where it acts on limb bud cells to stabilize the activity of the ZPA signal. Using our initial characterization of this maintenance activity, we have identified a growth factor, FGF-2 (bFGF), that can replace all of the ZPA signaling maintenance activity observed in microdissociate cultures...