... with ribosome biogenesis. We discovered that the half-life of fgf8a mRNA was reduced in ncl −/− mutants, which perturbed Fgf signaling, resulting in misregulated Sox9a-mediated chondrogenesis and Runx2-mediated osteogenesis. Consistent with this model, exogenous FGF8 treatment significantly rescued...

... for FGF signaling that might operate in a range of developing tissues. Doxycycline-inducible GATA4 -mCherry-inducible ESCs were generated by electroporation of 50,000 E14tg2a ESCs with 4 µg pPB-TET-GATA4-mCherry, 4 µg pCAG-rtTA-Neo and 4 µg pCAG-PBase ( Wang et al., 2008 ), followed by G418 selection...

.... Although this process of myotube guidance is essential to pattern the musculoskeletal system, the mechanisms that control myotube guidance remain poorly understood. Using transcriptomics, we found that components of the Fibroblast Growth Factor (FGF) signaling pathway were enriched in nascent myotubes...

... into adulthood. FGF signaling Lung development Myofibroblast Lipofibroblast Lineage tracing Alveolar macrophage Lung development results in an organ with the capacity to support efficient gas exchange in a mature animal. This is facilitated by the alveoli, the functional unit of air-gas...

...Rachel A. S. Kjolby; Marta Truchado-Garcia; Suvruta Iruvanti; Richard M. Harland ABSTRACT During Xenopus gastrulation, Wnt and FGF signaling pathways cooperate to induce posterior structures. Wnt target expression around the blastopore falls into two main categories: a horseshoe shape with a dorsal...

... compared with earlier steps in lung development. FGF signaling through receptors Fgfr3 and Fgfr4 is crucial for alveologenesis, but the mechanisms through which they mediate this process remain unclear. Here we show that in Fgfr3;Fgfr4 ( F gfr3;4 ) global mutant mice, alveolar simplification is first...

... http://www.biologists.com/user-licence-1-1/ Summary: Bmp4 activates the mesoderm progenitor gene network via key regulators, such as brachyury and Nkx1-2, and prevents premature differentiation to mesodermal-derived lineages. Bmp signaling Fgf signaling Mesoderm progenitor...

... and behaviors is unknown. Here we report that this cell type diversification involves the modulation of FGF signaling by the zinc-finger protein Escargot (Esg), which is expressed in the FC and is essential for its specification. The dorsal branch begins elongation with a pair of tip cells with high FGF...

... that exposure of mouse embryos to short-term gestational hypoxia induces the most common types of heart defect. This is mediated by the rapid induction of the unfolded protein response (UPR), which profoundly reduces FGF signaling in cardiac progenitor cells of the second heart field. Thus, UPR activation...

... is necessary for pouch outpocketing via the Fibroblast growth factor (Fgf) pathway. Double loss-of-function analyses demonstrate that Bmp and Fgf signaling interact synergistically in craniofacial development. Collectively, our analyses shed light on the tissue and signaling interactions that regulate...

...Kannan Karuppaiah; Kai Yu; Joohyun Lim; Jianquan Chen; Craig Smith; Fanxin Long; David M. Ornitz ABSTRACT Fibroblast growth factor (FGF) signaling is important for skeletal development; however, cell-specific functions, redundancy and feedback mechanisms regulating bone growth are poorly understood...

... the expression of Sox10 to promote the formation of secretory acinar lobes in the lacrimal gland. Sox9 and FGF signaling were required for the expression of cartilage-associated extracellular matrix components during early stage lacrimal gland development. Fgfr2 deletion in the ocular surface epithelium reduced...

... ( eldad.tzahor@weizmann.ac.il ) Competing interests The authors declare no competing financial interests. 12 12 2013 30 4 2014 © 2014. Published by The Company of Biologists Ltd 2014 ERK FGF signaling Myogenesis Chick Mouse Myogenesis, the formation of muscle tissue...

... ). fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo . Nature 427 , 419 – 422 . Dubrulle J. , McGrew M. J. , Pourquié O. ( 2001 ). FGF signaling controls somite boundary position and regulates segmentation clock control...

... to this work ‡ Author for correspondence ( j.deschamps@hubrecht.eu ) Competing interests statement The authors declare no competing financial interests. 5 5 2012 © 2012. 2012 Embryonic axial elongation Posterior growth zone Cdx and Hox genes Fgf signaling Post-occipital...

.... Young’s modulus Fgf signaling Organ of Corti Mouse Cells and tissues withstand mechanical stress during differentiation and development. One key mediator of mechanical stress is the formation of the cytoskeleton, which dictates both the cellular response to external force and cellular...

... Repressive Complex 1 (PRC1), is essential for pectoral fin development. We show that differentiation of lateral plate mesoderm (LPM) cells into presumptive pectoral fin precursors is initiated normally in ring1b mutants, but fin bud outgrowth is impaired. Fgf signaling, which is essential for migration...

... processes that leads to cleft lip and cleft palate. These cellular defects in Wnt9b –/– mice are mainly caused by reduced FGF family gene expression and FGF signaling activity resulting from compromised canonical WNT/β-catenin signaling. Our study has identified a previously unknown regulatory link between...

... CVM and TVM cells, respectively, suggested FGF signaling may influence CVM cell guidance. In FGF mutants, CVM cells die before reaching the anterior region of the TVM. However, an earlier phenotype observed was that the two cell clusters lose direction and converge at the midline. Live in vivo imaging...

... © 2011. FGF signaling Sprouty genes Incisor Mouse Tooth number is highly variable among mammalian species because of adaptive changes that were selected during evolution. In many cases, evolution led to a reduction of tooth number in extant species compared...