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Keywords: FGF signaling
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Journal Articles
Journal: Development
Development (2021) 148 (21): dev199926.
Published: 05 November 2021
... for FGF signaling that might operate in a range of developing tissues. Cell lines used in this study were E14tg2a ( Hooper et al., 1987 ) and an Fgf4 -mutant Spry4 H2B-Venus/+ line that we have described previously ( Morgani et al., 2018 ). dsRed-labeled cells were from an E14tg2a-background...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183624.
Published: 07 February 2020
.... Although this process of myotube guidance is essential to pattern the musculoskeletal system, the mechanisms that control myotube guidance remain poorly understood. Using transcriptomics, we found that components of the Fibroblast Growth Factor (FGF) signaling pathway were enriched in nascent myotubes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181032.
Published: 17 January 2020
... into adulthood. FGF signaling Lung development Myofibroblast Lipofibroblast Lineage tracing Alveolar macrophage Lung development results in an organ with the capacity to support efficient gas exchange in a mature animal. This is facilitated by the alveoli, the functional unit of air-gas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev179580.
Published: 09 August 2019
...Rachel A. S. Kjolby; Marta Truchado-Garcia; Suvruta Iruvanti; Richard M. Harland ABSTRACT During Xenopus gastrulation, Wnt and FGF signaling pathways cooperate to induce posterior structures. Wnt target expression around the blastopore falls into two main categories: a horseshoe shape with a dorsal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4563–4572.
Published: 15 December 2017
... compared with earlier steps in lung development. FGF signaling through receptors Fgfr3 and Fgfr4 is crucial for alveologenesis, but the mechanisms through which they mediate this process remain unclear. Here we show that in Fgfr3;Fgfr4 ( F gfr3;4 ) global mutant mice, alveolar simplification is first...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2982–2993.
Published: 15 August 2017
.... ( 2007 ). FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis . Development   134 , 4033 - 4041 . 10.1242/dev.009167 Wall , N. A. and Hogan , B. L. M. ( 1995 ). Expression of bone morphogenetic protein...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4261–4271.
Published: 15 November 2016
... and behaviors is unknown. Here we report that this cell type diversification involves the modulation of FGF signaling by the zinc-finger protein Escargot (Esg), which is expressed in the FC and is essential for its specification. The dorsal branch begins elongation with a pair of tip cells with high FGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2561–2572.
Published: 15 July 2016
... that exposure of mouse embryos to short-term gestational hypoxia induces the most common types of heart defect. This is mediated by the rapid induction of the unfolded protein response (UPR), which profoundly reduces FGF signaling in cardiac progenitor cells of the second heart field. Thus, UPR activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 2000–2011.
Published: 01 June 2016
... is necessary for pouch outpocketing via the Fibroblast growth factor (Fgf) pathway. Double loss-of-function analyses demonstrate that Bmp and Fgf signaling interact synergistically in craniofacial development. Collectively, our analyses shed light on the tissue and signaling interactions that regulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1811–1822.
Published: 15 May 2016
...Kannan Karuppaiah; Kai Yu; Joohyun Lim; Jianquan Chen; Craig Smith; Fanxin Long; David M. Ornitz ABSTRACT Fibroblast growth factor (FGF) signaling is important for skeletal development; however, cell-specific functions, redundancy and feedback mechanisms regulating bone growth are poorly understood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2611–2620.
Published: 01 July 2014
... ( eldad.tzahor@weizmann.ac.il ) Competing interests The authors declare no competing financial interests. 12 12 2013 30 4 2014 © 2014. Published by The Company of Biologists Ltd 2014 ERK FGF signaling Myogenesis Chick Mouse Myogenesis, the formation of muscle tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2691–2701.
Published: 01 July 2014
... the expression of Sox10 to promote the formation of secretory acinar lobes in the lacrimal gland. Sox9 and FGF signaling were required for the expression of cartilage-associated extracellular matrix components during early stage lacrimal gland development. Fgfr2 deletion in the ocular surface epithelium reduced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1381–1391.
Published: 15 March 2014
... use, distribution and reproduction in any medium provided that the original work is properly attributed. Fgf signaling Wnt signaling Embryonic elongation Segmentation clock Signal gradient Time-lapse microscopy Segmentation of the anteroposterior axis is a widespread...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (14): 2576–2583.
Published: 15 July 2012
..., and therefore the later and more 5′ Hox genes are not expressed. Our data in the mouse suggest that Fgf signaling works downstream of Cdx in driving post-occipital tissue emergence. Strikingly, in Tribolium, Tc-Fgf8 is expressed in a region of the posterior growth zone involved in axial elongation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (12): 2187–2197.
Published: 15 June 2012
... ; Hayashi et al., 2007 ; Puligilla et al., 2007 ). Furthermore, upregulation of Fgf signaling delays the differentiation of PCs ( Jacques et al., 2007 ). These studies suggest that proper growth factor signaling might regulate cytoskeletal formation and could dictate the developmental time course of cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (12): 2210–2220.
Published: 15 June 2012
... Repressive Complex 1 (PRC1), is essential for pectoral fin development. We show that differentiation of lateral plate mesoderm (LPM) cells into presumptive pectoral fin precursors is initiated normally in ring1b mutants, but fin bud outgrowth is impaired. Fgf signaling, which is essential for migration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1821–1830.
Published: 15 May 2012
... processes that leads to cleft lip and cleft palate. These cellular defects in Wnt9b –/– mice are mainly caused by reduced FGF family gene expression and FGF signaling activity resulting from compromised canonical WNT/β-catenin signaling. Our study has identified a previously unknown regulatory link between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (4): 699–708.
Published: 15 February 2012
... CVM and TVM cells, respectively, suggested FGF signaling may influence CVM cell guidance. In FGF mutants, CVM cells die before reaching the anterior region of the TVM. However, an earlier phenotype observed was that the two cell clusters lose direction and converge at the midline. Live in vivo imaging...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (18): 4063–4073.
Published: 15 September 2011
....-S. , Mustonen T. , Wang Y. , Thesleff I. ( 1999 ). Localization of putative stem cells in dental epithelium and their association with notch and FGF signaling . J. Cell Biol. 147 , 105 - 120 . Harada H. , Toyono T. , Toyoshima K. , Yamasaki M. , Itoh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1421–1432.
Published: 01 April 2011
... of an ancestral chordate, thus sharing conserved molecular developmental mechanisms with vertebrates. Chemical and targeted perturbation approaches revealed that a FGF signal, spreading in time from early gastrulation to neural tube closure, is responsible for pigment cell precursor induction. This signal...
Includes: Supplementary data