... plate via deletion of three FGF receptor (FGFR) genes. Triple FGFR mutant mice exhibit a complete loss of the telencephalon, except the dorsal midline. Disruption of FGF signaling prior to and coincident with telencephalic induction reveals that FGFs promote telencephalic character and are strictly...

...-mail: [email protected]) 28 8 2003 © The Company of Biologists Limited 2003 2003 Fgf8 Fgf17 Fgf18 Mid/hindbrain organizer FGF receptors Sprouty Mouse Chick Early patterning of the vertebrate presumptive midbrain and rhombomere 1(r1), which dorsally gives rise...

...). Conversely, blockage of FGF signaling by applying a specific FGF-inhibitor (SU5402) into the interdigital regions inhibits both physiological cell death and that mediated by exogenous BMPs. Furthermore, FGF receptors 1, 2 and 3 are expressed in the autopodial mesoderm during the regression...

... signal to the underlying mesenchyme during limb and craniofacial development. 31 07 1995 © 1995 by Company of Biologists 1995 fibroblast growth factor Fgf8 FGFR FGF receptors brain development limb development mouse embryogenesis oncogenes pharyngeal arches tyrosine kinase...

... that are products of individual genes. To investigate the role of FGFs in the growth and differentiation of embryonic tissues and to determine whether the individual FGF receptor genes might have specific functions, we compared the localization of mRNA for two FGF receptor genes, FGFR1 (the fig gene product...

.... The presence of FGF in the regenerating limb blastema of urodele amphibians also supports this notion (Boilly et al . 1991). Sagittal, parasagittal and transversal sections of whole embryos (Figs 6 , 7F -K and 8) demonstrate that the two FGF receptors are active in most developing organs. Sagittal...