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Keywords: FGF
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Journal Articles
Journal: Development
Development (2021) 148 (8): dev195651.
Published: 23 April 2021
... around E10.5. Expression analyses revealed partly disturbed regionalisation, and a posterior-ventral expansion of the neurogenic domain in Tbx2/3cDKO otocysts at this stage. We provide evidence that repression of FGF signalling by TBX2 is important to restrict neurogenesis to the anterior-ventral otocyst...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev186916.
Published: 16 April 2021
... organisms, and discusses the extent to which these processes are conserved between tendons and ligaments. Tendon Ligament Enthesis Scx Tenocyte Fibrous connective tissue Fgf Tendons and ligaments are closely related dense fibrous connective tissues that play vital roles in...
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
...Olga Ossipova; Keiji Itoh; Aurelian Radu; Jerome Ezan; Sergei Y. Sokol ABSTRACT Among the three embryonic germ layers, the mesoderm plays a central role in the establishment of the vertebrate body plan. The mesoderm is specified by secreted signaling proteins from the FGF, Nodal, BMP and Wnt...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184689.
Published: 28 April 2020
...Daniel P. S. Osborn; Kuoyu Li; Stephen J. Cutty; Andrew C. Nelson; Fiona C. Wardle; Yaniv Hinits; Simon M. Hughes ABSTRACT Skeletal muscle derives from dorsal mesoderm formed during vertebrate gastrulation. Fibroblast growth factor (Fgf) signalling cooperates with Tbx transcription factors to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev184507.
Published: 06 April 2020
... myoblast pools. We reveal that the non-cell-autonomous effect of MyHC-emb on myogenic progenitors and myoblasts is mediated by the fibroblast growth factor (FGF) signaling pathway, and exogenous FGF rescues the myogenic differentiation defects upon loss of MyHC-emb function in vitro . Adult Myh3 null mice...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev171405.
Published: 21 November 2019
... formation of ectopic pineal progenitors. We also demonstrate that fibroblast growth factors (FGFs) position the pineal progenitor domain within the non-neural border by repressing pineal fate and that the Otx transcription factors promote pinealogenesis by inhibiting this FGF activity. The non-neural origin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev183269.
Published: 08 November 2019
... cohesiveness. We reveal that cadherin switching diminishes the level of nuclear β-catenin, and that N-cadherin also dampens FGF activity and consequently stabilises neural fate. Finally, we compare the timing of cadherin switching and differentiation in vivo and in vitro , and find that this process becomes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev170241.
Published: 02 August 2019
... demonstrate that development of Scx + /Sox9 + progenitors within the mammalian lower jaw requires FGF signaling. We find that loss of Fgfr2 in the mouse tendon-bone interface reduces Scx expression in Scx + /Sox9 + progenitors and induces their biased differentiation into Sox9 + chondrocytes. This expansion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177295.
Published: 16 July 2019
...Frank Macabenta; Angelike Stathopoulos ABSTRACT In Drosophila embryos, caudal visceral mesoderm (CVM) cells undergo bilateral migration along the trunk visceral mesoderm (TVM) in order to form midgut muscles. Mutation of FGF receptor Heartless (Htl) has been shown to cause CVM migration defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev173575.
Published: 10 May 2019
... ciliated LR organizer (LRO). Although the role of fibroblast growth factor (FGF) signaling pathways during mesoderm development is conserved, diverging results from different model organisms suggest a non-conserved function in LR asymmetry. Here, we demonstrate that FGF is required during gastrulation in a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171496.
Published: 11 February 2019
... mesenchyme leads to the loss of basal cells and cartilage, concomitant with reduced transcript levels of Fgf10 in Dermo1-Cre;Ctnnb1 loxp/loxp mutants. Furthermore, deletion of Fgf receptor 2 ( Fgfr2 ) in the epithelium also leads to significantly reduced numbers of basal cells, supporting the importance of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev163824.
Published: 13 April 2018
... remains unclear whether Wnt/PCP signaling is regulated in a coordinated manner with embryonic patterning during morphogenesis. Here, in mouse developing limbs, we find that apical ectoderm ridge-derived Fgfs required for limb patterning regulate PCP along the proximal-distal axis in a Wnt5a-dependent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4047–4060.
Published: 15 November 2017
... orchestrated by a highly coordinated interplay of different growth factors and cytokines. Among the key players are the fibroblast growth factors (FGFs), which control the migration, proliferation, differentiation and survival of different cell types. In addition, FGFs influence the expression of other factors...
Journal Articles
Journal: Development
Development (2017) 144 (20): 3719–3730.
Published: 15 October 2017
... mammals. Furthermore, our results provide insight into the observed discrepancies relating to the role of FGF/ERK signalling in PrE versus EPI specification between mouse and other mammals. * Authors for correspondence ( a.piliszek@ighz.pl ; berenika.plusa@manchester.ac.uk ) Competing interests...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2652–2662.
Published: 15 July 2017
... + progenitor population relies on the activity of the Shh, Wnt and Fgf signaling pathways. Wnt and Fgf function additively to generate dHb progenitors. Surprisingly, Wnt signaling also negatively regulates fgf8a , confining expression to a discrete dorsal diencephalic domain. Moreover, the Wnt and Fgf pathways...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2212–2221.
Published: 15 June 2017
... structures is an unresolved issue. Fungiform papillae are repeated epithelial structures that house taste buds on the anterior tongue. Here, we report that FGF signaling is a crucial regulator of fungiform papillae development. We found that mesenchymal FGF10 controls the size of the papillary area, while...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1412–1424.
Published: 15 April 2017
... posteriormost embryonic structure, the tailbud. It is unclear to what extent the molecular mechanisms of mesoderm induction are conserved between gastrula and post-gastrula stages of development. Fibroblast growth factor (FGF) signaling is required for mesoderm induction during gastrulation through positive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4665–4675.
Published: 15 December 2016
...Ignacio A. Navarrete; Michael Levine Formation of the vertebrate neural tube represents one of the premier examples of morphogenesis in animal development. Here, we investigate this process in the simple chordate Ciona intestinalis . Previous studies have implicated Nodal and FGF signals in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 3994–4002.
Published: 01 November 2016
...Thuzar Thein; Jimmy de Melo; Cristina Zibetti; Brian S. Clark; Felicia Juarez; Seth Blackshaw Fibroblast growth factor (FGF) signaling is an essential regulator of lens epithelial cell proliferation and survival, as well as lens fiber cell differentiation. However, the identities of these FGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3661–3673.
Published: 15 October 2016
... FGF signals originated from the so-called isthmic organizer at the mid/hindbrain junction; however, the underlying mechanism is unclear. We show that deleting Ptpn11, which links FGF with the ERK pathway, prevents inferior colliculus formation by depleting a previously uncharacterized stem cell zone...
Includes: Supplementary data