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Keywords: F-actin
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Journal: Development
Development (2022) 149 (3): dev200195.
Published: 1 February 2022
...-wasb . Black, F-actin; red, nuclei. Bottom panel: pictogram of live imaging. Red ECs represent cells in aISVs; blue ECs represent cells in vISVs. Dark red ECs indicate cell division events (time point 31:10) and emigration of cells from aISV to DLAV (time points 35:20-38:20). Dark blue and dark red...
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Reproductive biology
Journal: Development
Development (2021) 148 (7): dev199364.
Published: 15 April 2021
... cortex is mediated by F-actin. Specifically, an F-actin cage surrounds the microtubule spindle and applies forces to it. To better understand how F-actin transmits forces to the spindle, we studied a potential direct link between F-actin and microtubules. For this, we tested the implication of myosin-X...
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Journal: Development
Development (2018) 145 (10): dev156604.
Published: 17 May 2018
... transmission, segregation and function in the zebrafish embryo . In Insights from Animal Reproduction (ed. R. P.   Carreira ), pp. 115 - 142 . Rijeka , Croatia : InTech . Eno , C. and Pelegri , F. ( 2018 ). Modulation of F-actin dynamics by maternal Mid1ip1l controls germ plasm...
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Journal Articles
Journal: Development
Development (2018) 145 (2): dev157909.
Published: 26 January 2018
... domain, which emerges together with the basal and lateral domains. Drosophila Cortical domains Epithelial domains Epithelial polarity Subapical F-actin Small GTPase Guanyl nucleotide exchange factor Cellularization Ced-12 China Scholarship Council 10.13039/501100004543...
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Journal Articles
Journal: Development
Development (2017) 144 (21): 3957–3967.
Published: 1 November 2017
... from the prevailing view that Rho inhibits Hippo signaling through modulating cytoskeleton remodeling and/or cell polarity. Active Rho prevents the phosphorylation of Amot Ser176, thus stabilizing the interaction between Amot and F-actin, and restricting the binding between Amot and Nf2. Moreover, Rho...
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Journal Articles
Journal: Development
Development (2016) 143 (9): 1585–1599.
Published: 1 May 2016
..., and abnormal cell wound healing. We show that the cytokinesis defects are associated with aberrant cytoskeletal reorganization during furrow maturation, including abnormal F-actin enrichment and microtubule reorganization. Cortical F-actin prior to furrow formation fails to exhibit a normal transition into F...
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Journal Articles
Journal: Development
Development (2015) 142 (17): 3058–3070.
Published: 1 September 2015
... to a defect in F-actin organization, both in vitro and in vivo , which secondarily impairs EC adhesion and polarity. We also identify Cdc42 effectors Pak2/4 and N-WASP, as well as the actomyosin machinery, to be crucial for EC actin organization. This work supports the notion of Cdc42 as a central regulator...
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Journal Articles
Journal: Development
Development (2015) 142 (10): 1869–1878.
Published: 15 May 2015
... was not required for adherens junction integrity, it was necessary for MZ localization of Moe, aPKC and F-actin. Furthermore, Moe and aPKC functioned antagonistically, suggesting that Moe limits Crb levels by reducing its interactions with the apical Par network. Additionally, Moe mutant cells lost Crb from...
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Journal Articles
Journal: Development
Development (2014) 141 (3): 650–660.
Published: 1 February 2014
..., we describe a cell-intrinsic pathway sculpting dendritic arborization (da) neurons in Drosophila that requires Longitudinals Lacking (Lola), a BTB/POZ transcription factor, and its control of the F-actin cytoskeleton through Spire (Spir), an actin nucleation protein. Loss of Lola from da neurons...
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Journal Articles
Journal: Development
Development (2012) 139 (10): 1851–1862.
Published: 15 May 2012
... the microvillar brush border of intestinal cells. Two of the isolated alleles ( kc2 and kc3 ) were mapped to the same gene, which we refer to as ifo-1 (intestinal filament organizer). The encoded polypeptide colocalizes with IF proteins and F-actin in the intestine. The apical localization of IFO-1 does not rely...
Journal Articles
Journal: Development
Development (2011) 138 (18): 3907–3914.
Published: 15 September 2011
...-actin regulated Yap downstream of cell morphology. Cell morphology- and F-actin-regulated phosphorylation of Yap, and the effects of F-actin were suppressed by modulation of Lats. Our results suggest that cell morphology is an important factor in the regulation of the Hippo pathway, which is mediated...
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Journal Articles
Journal: Development
Development (2011) 138 (14): 2903–2908.
Published: 15 July 2011
... in the organization of the cytoplasmic F-actin meshwork during the first meiotic division. It is very dense in prophase I, undergoes a significant density drop upon meiosis resumption and reforms progressively later on. This meshwork remodeling correlates with endogenous formin 2 regulation. High formin 2 levels...
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Journal Articles
Journal: Development
Development (2004) 131 (16): 3981–3989.
Published: 15 August 2004
...Sven Bogdan; Oliver Grewe; Mareike Strunk; Alexandra Mertens; Christian Klämbt Regulation of growth cone and cell motility involves the coordinated control of F-actin dynamics. An important regulator of F-actin formation is the Arp2/3 complex, which in turn is activated by Wasp and Wave. A complex...
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Journal Articles
Journal: Development
Development (2004) 131 (4): 725–732.
Published: 15 February 2004
... 2003 © 2004. 2004 Moesin ERM Morphogenesis Photoreceptor Cytoskeleton F-actin Drosophila melanogaster ERM proteins, dynamic, regulated membrane-cytoskeleton linkers essential to apical membrane traffic and regulation( Bretscher et al., 2002 ; Reczek and Bretscher, 2001...
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Journal Articles
Journal: Development
Development (2003) 130 (18): 4427–4437.
Published: 15 September 2003
... that in vivo as well as in tissue culture models most of the Kette protein is found in the cytoplasm where it colocalizes with F-actin to which it can bind via its N-terminal domain. Some Kette protein is localized at the membrane and accumulates at focal contact sites. Loss of Kette protein results...