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Keywords: F-actin
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Journal Articles
Journal: Development
Development (2022) 149 (3): dev200195.
Published: 1 February 2022
... and WASp-driven directed cell migration. Migration Proliferation WASp F-actin Vessel remodelling Shear stress Zebrafish Human Deutsches Zentrum für Herz-Kreislaufforschung Fig. 5. Wasb is required for F-actin regulation and junctional Pecam1 localization. (A) Upper panel...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2021) 148 (7): dev199364.
Published: 15 April 2021
... cortex is mediated by F-actin. Specifically, an F-actin cage surrounds the microtubule spindle and applies forces to it. To better understand how F-actin transmits forces to the spindle, we studied a potential direct link between F-actin and microtubules. For this, we tested the implication of myosin-X...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev156596.
Published: 17 May 2018
... through their association with the tips of growing interphase astral microtubules. Germ plasm RNPs are also associated with short cortical F-actin. We show that, in embryos mutant for the cytoskeletal regulator mid1ip1l , germ plasm RNPs fail to become recruited to the furrow, accumulating instead...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev156604.
Published: 17 May 2018
... and Pelegri, 2018 ) indicate that calcium- and myosin-dependent contractility, as well as F-actin dynamics, are essential for the distal reorganization of germ plasm RNPs and associated FMA. Three-dimensional reconstructions show that, in control wild-type embryos, F-actin in the contractile ring forms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev157909.
Published: 26 January 2018
.... , Magrath , R. and Webb , S. ( 1984 ). Distribution of F-actin during cleavage of the Drosophila syncytial blastoderm . J. Cell Biol.   98 , 156 - 162 . 10.1083/jcb.98.1.156 Wenzl , C. , Yan , S. , Laupsien , P. and Großhans , J. ( 2010 ). Localization of RhoGEF2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3957–3967.
Published: 1 November 2017
... from the prevailing view that Rho inhibits Hippo signaling through modulating cytoskeleton remodeling and/or cell polarity. Active Rho prevents the phosphorylation of Amot Ser176, thus stabilizing the interaction between Amot and F-actin, and restricting the binding between Amot and Nf2. Moreover, Rho...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (9): 1585–1599.
Published: 1 May 2016
..., and abnormal cell wound healing. We show that the cytokinesis defects are associated with aberrant cytoskeletal reorganization during furrow maturation, including abnormal F-actin enrichment and microtubule reorganization. Cortical F-actin prior to furrow formation fails to exhibit a normal transition into F...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 3058–3070.
Published: 1 September 2015
... to a defect in F-actin organization, both in vitro and in vivo , which secondarily impairs EC adhesion and polarity. We also identify Cdc42 effectors Pak2/4 and N-WASP, as well as the actomyosin machinery, to be crucial for EC actin organization. This work supports the notion of Cdc42 as a central regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (16): 2752–2763.
Published: 15 August 2015
... occurs in high cell density areas, conditional to F-actin distribution and polymerization. We propose that Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity. * Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1869–1878.
Published: 15 May 2015
... was not required for adherens junction integrity, it was necessary for MZ localization of Moe, aPKC and F-actin. Furthermore, Moe and aPKC functioned antagonistically, suggesting that Moe limits Crb levels by reducing its interactions with the apical Par network. Additionally, Moe mutant cells lost Crb from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (24): 4716–4728.
Published: 15 December 2014
... and through a Pak-independent non-canonical pathway to promote outgrowth. Whether this non-canonical pathway converges to promote Cofilin-dependent F-actin reorganization in axonal growth remains elusive. We demonstrate that Sickie, a homolog of the human microtubule-associated protein neuron navigator 2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1366–1380.
Published: 15 March 2014
... of unbranched F-actin is induced by several members of the formin family. Drosophila encodes six formin genes, representing six of the seven known mammalian subclasses. Knittrig, the Drosophila homolog of mammalian FHOD1, is specifically expressed in the developing central nervous system midline glia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 650–660.
Published: 1 February 2014
..., we describe a cell-intrinsic pathway sculpting dendritic arborization (da) neurons in Drosophila that requires Longitudinals Lacking (Lola), a BTB/POZ transcription factor, and its control of the F-actin cytoskeleton through Spire (Spir), an actin nucleation protein. Loss of Lola from da neurons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1851–1862.
Published: 15 May 2012
... the microvillar brush border of intestinal cells. Two of the isolated alleles ( kc2 and kc3 ) were mapped to the same gene, which we refer to as ifo-1 (intestinal filament organizer). The encoded polypeptide colocalizes with IF proteins and F-actin in the intestine. The apical localization of IFO-1 does not rely...
Journal Articles
Journal: Development
Development (2011) 138 (18): 3907–3914.
Published: 15 September 2011
...-actin regulated Yap downstream of cell morphology. Cell morphology- and F-actin-regulated phosphorylation of Yap, and the effects of F-actin were suppressed by modulation of Lats. Our results suggest that cell morphology is an important factor in the regulation of the Hippo pathway, which is mediated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2903–2908.
Published: 15 July 2011
... in the organization of the cytoplasmic F-actin meshwork during the first meiotic division. It is very dense in prophase I, undergoes a significant density drop upon meiosis resumption and reforms progressively later on. This meshwork remodeling correlates with endogenous formin 2 regulation. High formin 2 levels...
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Journal Articles
Journal: Development
Development (2010) 137 (8): 1315–1325.
Published: 15 April 2010
... impaired neural fold formation by attenuating F-actin accumulation and apical constriction, a cell-shape change that is required for neural tube folding. Conversely, the overexpression of nectin-2 in non-neural ectoderm induced ectopic apical constrictions with accumulated F-actin. However, experiments...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 3981–3989.
Published: 15 August 2004
...Sven Bogdan; Oliver Grewe; Mareike Strunk; Alexandra Mertens; Christian Klämbt Regulation of growth cone and cell motility involves the coordinated control of F-actin dynamics. An important regulator of F-actin formation is the Arp2/3 complex, which in turn is activated by Wasp and Wave. A complex...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (4): 725–732.
Published: 15 February 2004
... in photoreceptors of a Moesin mutant previously regarded as protein null, suggesting alternative interpretations for studies using this allele. Our results show an essential structural role for Moesin in photoreceptor morphology. Immunostaining and F-actin localization were performed with whole-mount preparations...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (18): 4427–4437.
Published: 15 September 2003
... that in vivo as well as in tissue culture models most of the Kette protein is found in the cytoplasm where it colocalizes with F-actin to which it can bind via its N-terminal domain. Some Kette protein is localized at the membrane and accumulates at focal contact sites. Loss of Kette protein results...