...’ called Pax6 , which is both necessary and sufficient for eye development. Yet precisely how Pax6 achieves this deeply homologous function is poorly understood. Using the chick as a model organism, we show that vertebrate Pax6 interacts with a pair of morphogen-coding genes, Tgfb2 and Fst , to form...

... during Drosophila eye development. Fizzy/Cdc20 controls the early growth of the eye disc anlage and the concomitant entry of glial cells onto the disc. In contrast, fzr/cdh1 acts during neuronal patterning and photoreceptor axon growth, and subsequently affects neuron-glia interaction. To further address...

.... ( 2002 ). Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt . Genes Dev.   16 , 2415 - 2427 . 10.1101/gad.1009002 Bischof , J. , Maeda , R. K. , Hediger , M. , Karch , F. and Basler , K. ( 2007 ). An optimized transgenesis system...

... a direct interaction between Sipa1l3 and Epha4, building a functional platform for proper ocular development. Epha4 deficiency phenocopied loss of Sipa1l3 and rescue experiments demonstrated that Epha4 acts upstream of Sipa1l3 during eye development, with both Sipa1l3 and Epha4 required for early eye...

... , T. M. , et al. ( 2015 ). CRIM1 haploinsufficiency causes defects in eye development in human and mouse . Hum. Mol. Genet.   24 , 2267 - 2273 . 10.1093/hmg/ddu744 Cammas , L. , Wolfe , J. , Choi , S.-Y. , Dedhar , S. and Beggs , H. E. ( 2012 ). Integrin-linked...

... , H. , Carney , K. R. , Saijoh , Y. and Chien , C.-B. ( 2012 ). A complex choreography of cell movements shapes the vertebrate eye . Development   139 , 359 - 372 . 10.1242/dev.071407 Link , V. , Shevchenko , A. and Heisenberg , C.-P. ( 2006 ). Proteomics...

... by The Company of Biologists Ltd 2015 Summary: MicroRNAs expressed in the mouse RPE are dispensable for RPE specification and survival but are required for maturation and differentiation of the RPE and adjacent photoreceptors. RPE Dicer1 Dgcr8 MicroRNA Eye development Photoreceptor Mouse...

.... Published by The Company of Biologists Ltd 2013 EGFR signaling ETS proteins Pointed MAP kinase Eye development pntP2 GFP was generated as follows: a pntP2 cDNA was amplified by PCR and cloned into the Drosophila Gateway vector pTGW (T. Murphy, Carnegie Institution...

...Ke Tang; Xin Xie; Joo-In Park; Milan Jamrich; Sophia Tsai; Ming-Jer Tsai Transcriptional networks, which are initiated by secreted proteins, cooperate with each other to orchestrate eye development. The establishment of dorsal/ventral polarity, especially dorsal specification in the optic vesicle...

... IRSp53 (Baiap2) Eye development Filopodia Lens development Morphogenesis Mouse A fundamental process in determining the shape of organs is cellular sheet folding and invagination ( Lecuit and Lenne, 2007 ) as exemplified by the developing neural tube, eye,ear and heart. Invagination...

...José Bessa; Maria J. Tavares; Joana Santos; Hiroshi Kikuta; Mary Laplante; Thomas S. Becker; José Luis Gómez-Skarmeta; Fernando Casares During eye development, retinal progenitors are drawn from a multipotent,proliferative cell population. In Drosophila the maintenance of this cell population...

... in the surface ectoderm overlying the optic vesicle, the surrounding mesenchyme and/or presumptive RPE during the initial stages of eye development. During the initial stages of chick eye development the microphthalmia-associated transcription factor( Mitf ), important for RPE development, is expressed...

... required for Xenopus eye development. Kermit 2/XGIPC functions downstream of IGF in eye formation and is required for maintaining IGF-induced AKT activation. A constitutively active PI3 kinase partially rescues the Kermit 2/XGIPC loss-of-function phenotype. Our results provide the first in vivo loss...

... ) * These authors contributed equally to this work 9 11 2005 © 2006. 2006 Retinoids Forebrain development Eye development Neural crest Telencephalon Diencephalon Optic vesicle Pituitary Sonic hedgehog FGF Mouse Aldh1a2 The embryonic forebrain...

.... Chow, R. L. and Lang, R. A. ( 2001 ). Early eye development in vertebrates. Annu. Rev. Cell Dev. Biol. 17 , 255 -296. Chuang, J. C. and Raymond, P. A. ( 2002 ). Embryonic origin of the eyes in teleost fish. BioEssays 24 , 519 -529. Crossley, P. H., Martinez, S. and Martin, G. R. ( 1996...

...-mail: bertrand.mollereau@rockefeller.edu ) 14 9 2004 © 2004. 2004 spalt seven-up Drosophila Planar cell polarity Eye development Planar cell polarity (PCP), also known as tissue polarity, occurs when epithelial cells are polarized along the plane of the epithelium(perpendicular...

... et al., 2002 ). In this light, the original model in which the mutual repression of Pax2 and Pax6 was assumed to direct the spatial segregation of territories in the early eye( Schwarz et al., 2000 ) might only apply to later aspects of eye development, such as optic-cup morphogenesis. Such mutual...

...Chuen-Chuen Jang; Ju-Lan Chao; Nikolas Jones; Li-Chin Yao; Dmitri A. Bessarab; Yien M. Kuo; Susie Jun; Claude Desplan; Steven K. Beckendorf; Y. Henry Sun We report the identification of a Drosophila Pax gene, eye gone ( eyg ), which is required for eye development. Loss-of-function eyg mutations...

...Matthias Carl; Felix Loosli; Joachim Wittbrodt The establishment of retinal identity and the subsequent patterning of the optic vesicle are the key steps in early vertebrate eye development. To date little is known about the nature and interaction of the genes controlling these steps. So far few...

... mice does not cause the adjacent lens epithelial cells to form lens fibers ( Shirke et al., 2001 ) and targeted deletion of the IGF receptor in mice has no reported effect on eye development ( Liu et al., 1993 ; Louvi et al., 1997 ). Therefore, factors other than FGFs and IGFs may be involved in lens...