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Keywords: Eye
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Journal Articles
Journal: Development
Development (2021) 148 (22): dev199700.
Published: 30 November 2021
...Donald F. Ready; Henry C. Chang ABSTRACT Actomyosin contraction shapes the Drosophila eye's panoramic view. The convex curvature of the retinal epithelium, organized in ∼800 close-packed ommatidia, depends upon a fourfold condensation of the retinal floor mediated by contraction of actin stress...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (10): dev196147.
Published: 27 May 2021
.... Comparison with mice deficient for integrase interactor 1 ( Ini1 , also known as Smarcb1 ) revealed that the enlarged NR was Brg1 specific and was not caused by a general dysfunction of the SWI/SNF complex. These results suggest a crucial role for Brg1 in NSCs during brain and eye development. * Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev182923.
Published: 13 October 2020
...Kristen M. Koenig; Jeffrey M. Gross ABSTRACT For centuries, the eye has fascinated scientists and philosophers alike, and as a result the visual system has always been at the forefront of integrating cutting-edge technology in research. We are again at a turning point at which technical advances...
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181420.
Published: 21 February 2020
...Chase D. Bryan; Macaulie A. Casey; Rebecca L. Pfeiffer; Bryan W. Jones; Kristen M. Kwan ABSTRACT Organogenesis requires precise interactions between a developing tissue and its environment. In vertebrates, the developing eye is surrounded by a complex extracellular matrix as well as multiple...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev165068.
Published: 19 November 2018
... hpf, host embryos were screened for donor cells in the eye region and mounted for time-lapse imaging. Embryos were screened for a second time under the confocal microscope for donor cells residing within the midline region, the area from which prospective nasal optic fissure cells arise. After time...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163329.
Published: 02 August 2018
...Luke R. Baker; Bonnie M. Weasner; Athena Nagel; Sarah D. Neuman; Arash Bashirullah; Justin P. Kumar ABSTRACT The transcription factor Pax6 is considered the master control gene for eye formation because (1) it is present within the genomes and retina/lens of all animals with a visual system; (2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev160754.
Published: 04 April 2018
... urchins and frogs. Here, we demonstrate that Polycomb group (PcG) proteins maintain Drosophila eye specification by suppressing the activation of alternative fate choices. The loss of PcG in the developing eye results in a cellular reprogramming event in which the eye is redirected to a wing fate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1850–1859.
Published: 15 May 2015
...Tanushree Pandit; Vijay K. Jidigam; Cedric Patthey; Lena Gunhaga The eye has served as a classical model to study cell specification and tissue induction for over a century. Nevertheless, the molecular mechanisms that regulate the induction and maintenance of eye-field cells, and the specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 1006–1015.
Published: 01 March 2015
... to obtain directional and positional information. Within the Drosophila retina, D/V axis formation is essential to ensure that each unit eye first adopts the proper chiral form and then rotates precisely 90° in the correct direction. These two steps are important because the photoreceptor array must...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 3072–3083.
Published: 01 August 2014
... have shown that Drosophila integrins form adhesion complexes with Integrin-linked kinase and talin in the peripheral nerve glia and have conserved roles in glial sheath formation. However, integrin function in other aspects of glial development is unclear. The Drosophila eye imaginal disc (ED...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1884–1893.
Published: 01 May 2014
..., in the developing eye. In this tissue, the Dpp expression domain advances from the posterior to the anterior tissue edge. In front of this moving morphogen source, signaling inputs including Dpp activate the target gene hairy in a gradient that scales with tissue size. Proliferation, in turn, occurs in a mitotic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4959–4969.
Published: 15 December 2013
...Jörg Steinfeld; Ichie Steinfeld; Nicola Coronato; Meggi-Lee Hampel; Paul G. Layer; Masasuke Araki; Astrid Vogel-Höpker The retinal pigment epithelium (RPE) is indispensable for vertebrate eye development and vision. In the classical model of optic vesicle patterning, the surface ectoderm produces...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (21): 4353–4361.
Published: 01 November 2013
..., 1994 ; Freeman, 1996 ; Kumar et al., 1998 ), whereas Bride of sevenless (Boss) is an integral membrane protein that activates the Sevenless (Sev) RTK in immediately adjacent cells ( Hafen et al., 1987 ; Krämer et al., 1991 ; Reinke and Zipursky, 1988 ). The N ligand in the developing eye is Delta...
Journal Articles
Journal: Development
Development (2013) 140 (9): 1994–2004.
Published: 01 May 2013
...Carrie M. Spratford; Justin P. Kumar The compound eye of Drosophila melanogaster is configured by a differentiating wave, the morphogenetic furrow, that sweeps across the eye imaginal disc and transforms thousands of undifferentiated cells into a precisely ordered repetitive array of 800 ommatidia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (4): 719–729.
Published: 15 February 2013
...-posterior polarized responses to wounds, indicating that pbx is required after wound responses for development and maintenance of poles during regeneration and homeostatic tissue turnover. Independently of the requirement for pbx in pole regeneration, pbx is required for eye precursor formation...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 205–215.
Published: 01 January 2013
...Bonnie M. Weasner; Justin P. Kumar The eye-antennal disc of Drosophila gives rise to numerous adult tissues, including the compound eyes, ocelli, antennae, maxillary palps and surrounding head capsule. The fate of each tissue is governed by the activity of unique gene regulatory networks (GRNs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 359–372.
Published: 15 January 2012
...Kristen M. Kwan; Hideo Otsuna; Hinako Kidokoro; Keith R. Carney; Yukio Saijoh; Chi-Bin Chien Optic cup morphogenesis (OCM) generates the basic structure of the vertebrate eye. Although it is commonly depicted as a series of epithelial sheet folding events, this does not represent an empirically...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2369–2378.
Published: 01 June 2011
...), are essential for eukaryotic ribosome biogenesis. In this study, we demonstrate that PPan is expressed maternally as well as in the eye and cranial neural crest cells (NCCs) during early Xenopus laevis development. Depletion of PPan and interference with rRNA processing using antisense morpholino...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2955–2964.
Published: 01 September 2009
... ale oko Dynactin Photoreceptor Glia Eye Retina Retinotectal Hair cell Axon Polarity Spindle Microtubules play many essential roles in the structure and function of most, if not all, cells. As a component of the cytoskeleton, they provide structural support for morphological features...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (17): 2977–2985.
Published: 01 September 2009
... is illustrated by the dramatic failure of lens and eye development in presumptive lens conditional, compound Sox2, Pax6 heterozygotes. The resulting phenotype resembles that of germ line Pax6 inactivation, and the failure of optic cup morphogenesis indicates the importance of ectoderm-derived signals for all...