... provided that the original work is properly attributed. Summary: Two parallel sensory lines in medaka share a common origin and are composed of identical organs that are, nevertheless, generated through different morphogenetic programmes. Organogenesis Lateral line Cxcr4b Cxcr7 Eya1...

..., activates Ret signaling in the Wolffian duct to initiate the formation of the metanephros. However, the molecular mechanism for induction of Gdnf in the metanephric mesenchyme is not completely defined. Previous studies demonstrated that during the early stages of kidney development, loss of Osr1, Eya1...

... that EYA1 and SIX1 are crucial otic neuronal determination factors upstream of NEUROG1 and NEUROD1. Overexpression of both Eya1 and Six1 is sufficient to convert non-neuronal epithelial cells within the otocyst and cochlea as well as the 3T3 fibroblast cells into neurons. Strikingly, all the ectopic neurons...

..., LGN (Gpsm2) and NuMA, and the cell fate determinant Numb are asymmetrically localized in embryonic lung distal epithelium. Interfering with the function of these proteins in vitro randomizes spindle orientation and changes cell fate. We further show that Eya1 protein regulates cell polarity, spindle...

...Dan Zou; Derek Silvius; Bernd Fritzsch; Pin-Xian Xu Eya1 encodes a transcriptional co-activator and is expressed in cranial sensory placodes. It interacts with and functions upstream of the homeobox gene Six1 during otic placodal development. Here, we have examined their role in cranial sensory...

... and all components of the inner ear failed to form due to increased cell death and reduced cell proliferation in the otic epithelium. Because we previously reported that Six1 expression in the otic vesicle is Eya1 dependent, we first clarified that Eya1 expression was unaffected in Six1 -/- otic vesicle...

... in the metanephric mesenchyme. In contrast, Eya1 expression was unaffected in Six1 -/- metanephric mesenchyme at E10.5,indicating that Eya1 may function upstream of Six1 . Moreover, our results show that both Eya1 and Six1 expression in the metanephric mesenchyme is preserved in Pax2 -/- embryos at E10.5, further...

...Pin-Xian Xu; Weiming Zheng; Christine Laclef; Pascal Maire; Richard L. Maas; Heiko Peters; Xin Xu Eyes absent ( Eya ) genes regulate organogenesis in both vertebrates and invertebrates. Mutations in human EYA1 cause congenital Branchio-Oto-Renal (BOR) syndrome, while targeted inactivation of murine...