... and E2f1 . Here, we show that, in addition to these mechanisms, some Notch signaling is devoted to blocking the growth-suppressing activity of the bHLH DNA-binding protein Daughterless (Da). We demonstrate that Notch signaling activates the expression of extramacrochaetae ( emc ), which encodes a helix...

... ), a TGFβ homolog. In this report, we describe a mechanism that is in place within the fly retina to limit Hh pathway activity within and ahead of the furrow. We demonstrate that the helix-loop-helix (HLH) protein Extramacrochaetae (Emc) regulates Ci 155 levels. Loss of emc leads to an increase in Ci 155...

...Antonio Baonza; Jose F. de Celis; Antonio García-Bellido ABSTRACT The function of extramacrochaetae is required during the development of the Drosophila wing in processes such as cell proliferation and vein differentiation. extramacrochaetae encodes a transcription factor of the HLH family...

... extramacrochaetae Drosophila Helix-Loop-Helix pattern formation The pattern of sensilla of the adult Drosophila has been a recurrent theme in the study of pattern formation ( Osten-Sacken, 1881 ; Sturtevant, 1921 ; Stern, 1968 ). A set of mechanoreceptors of the notum called macrochaeta...

...Pilar Cubas; Juan Modolell; Mar Gómez ABSTRACT The Drosophila Extramacrochaetae protein antagonizes the proneural function of the Achaete and Scute proteins in the generation of the adult fly sensory organs. Extra-macrochaetae sequesters these basic-region-helix-loop-helix transcription factors...

... as a negative post-translational regulator of achaete and scute . The protein kinase shaggy also represses achaete and scute at many sites hut may act via intermediate transcription factors. However shaggy and extramacrochaetae act synergistically and molecular studies suggest that they may be part of the same...