... these to predict key hallmarks of naïve pluripotency in primates. Amnion Epiblast Extraembryonic Naïve pluripotency Postimplantation Primate In this Hypothesis article, we advocate that preimplantation epiblast identity is imperative for the naïve state in human and non-human primates. We...

... for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario M5G 1L7, Canada 16 2 2009 © 2009. 2009 Nanog hESCs Activin Nodal Smad2/3 Neuroectoderm Endoderm Mesendoderm Extraembryonic Mouse Human Human embryonic stem cells (hESCs) are pluripotent cells derived...

... implantation (5.5 days postcoitum). Chimeric experiments show this to be caused by an indirect effect on the epiblast due to a defect in an extraembryonic tissue. Embryos from heterozygous matings were dissected according to standard methods ( Hogan et al., 1994 ) and part or all of the embryo, older...

... implantation (5.5 days postcoitum). Chimeric experiments show this to be caused by an indirect effect on the epiblast due to a defect in an extraembryonic tissue. * Author for correspondence (e-mail: [email protected] ) 14 12 1998 19 10 1998 © 1999 by Company of Biologists 1999...

... to forming only an extraembryonic EVL fate, though somewhat after the time when they can be first fatemapped as a separate lineage. The morphogenetic movements that occur during zebrafish gastrulation appear similar to the cellular movements described in other vertebrates, especially amphibians. Because...