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Keywords: Extracellular matrix
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (19): dev201203.
Published: 17 October 2022
... of alveolar bone and cementum, respectively. However, the characteristics and lineage hierarchy of each cell type remain poorly defined. This study identified periodontal ligament associated protein-1 (Plap-1) as a PDL-specific extracellular matrix protein. We generated knock-in mice expressing CreER T2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200140.
Published: 13 January 2022
... of how these cells recognise their ‘inside’ position to instruct their fate is unknown. Here, we show that provision of extracellular matrix (ECM) to isolated embryonic cells induces ICM specification and alters the subsequent spatial arrangement between epiblast (EPI) and primitive endoderm (PrE) cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199691.
Published: 22 October 2021
... simultaneously with growth of the heart. Cardiac growth during early heart morphogenesis is driven by deployment of cells from the second heart field (SHF) into both poles of the heart. Laminin is a core component of the extracellular matrix and, although mutations in laminin subunits are linked with cardiac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev199281.
Published: 15 June 2021
... , M. C. , Inman , J. L. , Petersen , O. W. and Bissell , M. J. ( 2005 ). Myoepithelial cells: good fences make good neighbors . Breast Cancer Res. 7 , 190 - 197 . 10.1186/bcr1286 Ahmed , M. and Ffrench-Constant , C. ( 2016 ). Extracellular matrix regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev191320.
Published: 5 March 2021
...Christopher J. Derrick; Emily S. Noël ABSTRACT The developing heart is formed of two tissue layers separated by an extracellular matrix (ECM) that provides chemical and physical signals to cardiac cells. While deposition of specific ECM components creates matrix diversity, the cardiac ECM is also...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193219.
Published: 18 January 2021
... and improves the resolution of transient collagen deposition. Through loss- and gain-of-function as well as pharmacological approaches, we provide evidence that Ccn2a is necessary for and promotes heart regeneration by enhancing the expression of pro-regenerative extracellular matrix genes, and by inhibiting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193094.
Published: 23 September 2020
.... , Hubmacher , D. , Li , M. X. , Hupe , M. , et al. ( 2019 ). Disruption of the extracellular matrix progressively impairs central nervous system vascular maturation downstream of beta-catenin signaling . Arterioscler. Thromb. Vasc. Biol.   39 , 1432 - 1447 . 10.1161/ATVBAHA.119.312388...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev190983.
Published: 18 September 2020
.../user-licence-1-1/ Summary: This study reports a role for the COP-II secretory pathway and the cargo Col2a1 in controlling the migration of lymphatic endothelial cells in the developing embryo. Sec23a Mbtps1 Col2a1 Lymphangiogenesis Extracellular matrix Collagen Zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev175596.
Published: 28 May 2020
...David A. Cruz Walma; Kenneth M. Yamada ABSTRACT As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others provide a sheet-like...
Journal Articles
Journal: Development
Development (2020) 147 (7): dev186957.
Published: 8 April 2020
...Fabiana Cerqueira Campos; Cynthia Dennis; Hervé Alégot; Cornelia Fritsch; Adam Isabella; Pierre Pouchin; Olivier Bardot; Sally Horne-Badovinac; Vincent Mirouse ABSTRACT How extracellular matrix contributes to tissue morphogenesis is still an open question. In the Drosophila ovarian follicle, it has...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (4): dev181420.
Published: 21 February 2020
...Chase D. Bryan; Macaulie A. Casey; Rebecca L. Pfeiffer; Bryan W. Jones; Kristen M. Kwan ABSTRACT Organogenesis requires precise interactions between a developing tissue and its environment. In vertebrates, the developing eye is surrounded by a complex extracellular matrix as well as multiple...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185306.
Published: 2 December 2019
... induces fibroblast migration in 3D extracellular matrix (ECM) through regulation of actomyosin cytoskeleton and promotes force-mediated collagen remodeling by mammary fibroblasts. Moreover, FGF2 regulates production of ECM proteins by mammary fibroblasts, including collagens, fibronectin, osteopontin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev172668.
Published: 29 August 2019
... and survival of midbrain dopaminergic neurons is regulated by laminin α2, mutations in which can cause abnormalities in dopaminergic neuron number. Extracellular matrix Neural stem cells Laminin Integrin Dystroglycan Dopaminergic neurons Congenital muscular dystrophy During development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev178400.
Published: 19 July 2019
... zebrafish as a model, we describe the in vivo dynamics and function of embryonic muscle progenitor cells (MPCs) in the dermomyotome. These cells are located in a superficial layer external to muscle fibers and express many extracellular matrix (ECM) genes, including collagen type 1 α2 ( col1a2 ). Utilizing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (11): dev172577.
Published: 3 June 2019
...Amsha Proag; Bruno Monier; Magali Suzanne ABSTRACT Tissue mechanics play a crucial role in organ development. They rely on the properties of cells and the extracellular matrix (ECM), but the relative physical contribution of cells and ECM to morphogenesis is poorly understood. Here, we have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev174367.
Published: 1 May 2019
...-mediated extracellular matrix signals in fibroblasts via its LD motifs to regulate pMLC-dependent contractility and coordinate cell motility ( Brown and Turner, 2004 ; Deakin and Turner, 2008 ; Turner et al., 1999 ; Webb et al., 2004 ), and we also observed defects in β1 integrin and FAK signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev168948.
Published: 16 January 2019
...Georg Wolfstetter; Ina Dahlitz; Kathrin Pfeifer; Uwe Töpfer; Joscha Arne Alt; Daniel Christoph Pfeifer; Reinhard Lakes-Harlan; Stefan Baumgartner; Ruth H. Palmer; Anne Holz ABSTRACT Basement membranes (BMs) are specialized layers of extracellular matrix (ECM) mainly composed of Laminin, type IV...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev167197.
Published: 25 October 2018
... . 10.15252/embj.201695273 Thomas , K. , Engler , A. J. and Meyer , G. A. ( 2015 ). Extracellular matrix regulation in the muscle satellite cell niche . Connect. Tissue Res.   56 , 1 - 8 . 10.3109/03008207.2014.947369 Tierney , M. T. , Stec , M. J. , Rulands , S...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev161281.
Published: 5 October 2018
... in cell shape in the PSM during neurulation. (C) Schematic of tissue architecture disruption. Tissues were isolated at neurula stage, dissociated, and re-aggregated into ‘scrambled’ tissues. Mechanical properties and extracellular matrix organization within scrambled tissues were compared with native...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev163303.
Published: 28 August 2018
... in the expression and assembly of fibronectin and laminin, major components of the extracellular matrix (ECM). Notably, we found that matrix metalloproteinase 14 (Mmp14a/b) is required for the control of ECM expression during endoderm migration, with Gpc4 acting through Mmp14a/b to limit ECM expression. Our results...
Includes: Supplementary data