... defense against micro-organisms and in the pathophysiology of several inflammatory skin diseases. To understand the role of TLRs in the acquisition of immunological competence, we conducted a comprehensive study to evaluate TLR expression and function in the developing human skin before and after birth...

... suggest patterning roles for anterior visceral endoderm (AVE) and ADE. Based on similarity of gene expression patterns, fate and a dual role in`protecting' the prospective forebrain from caudalising influences of the organiser, the chick hypoblast has been suggested to be the homologue of the mouse...

...-containing proteins are involved in Notch signaling in Drosophila and C. elegans via an ectodomain shedding mechanism that depends on a metalloprotease domain. The Dictyostelium protein lacks a metalloprotease domain. Nonetheless, analysis of cell type specific reporter gene expression during development...

...Hui Fu; Yingchuan Qi; Min Tan; Jun Cai; Hirohide Takebayashi; Masato Nakafuku; William Richardson; Mengsheng Qiu In this study, we have investigated the relationship of Olig2 + and Nkx2.2+ oligodendrocyte progenitors (OLPs) by comparing the expression of Olig2 and Nkx2.2 in embryonic chicken...

... have cloned two chick NGNs and found that they are expressed in a subset of neural crest cells early in their migration. Ectopic expression of the NGNs in vivo biases migrating neural crest cells to localize in the sensory ganglia, and induces the expression of sensory neuron-appropriate markers in non...

...Thomas Braun; Eva Bober; Michael A. Rudnicki; Rudolf Jaenisch; Hans-Henning Arnold ABSTRACT The expression pattern of myogenic regulatory factors and myotome-specific contractile proteins was studied during embryonic development of Myf-5 mutant mice by in situ hybridization and immunohistochemistry...

...Kathleen M. George; Mark W. Leonard; Matthew E. Roth; Ken H. Lieuw; Dimitris Kioussis; Frank Grosveld; James Douglas Engel ABSTRACT We describe the embryonic expression pattern as well as the cloning and initial transcriptional regulatory analysis of the murine (m) GATA-3 gene. In situ...

..., Sax1 continues to be expressed only in the spinal part of the neural plate. The anterior border of Sax1 expression was found to be always in the transverse plane separating the youngest somite from the yet unsegmented mesodermal plate and to regress with similar dynamics to that of the segregation...

...Anna Pavlova; Eugenie Boutin; Gerald Cunha; David Sassoon ABSTRACT We report here that Msx1 (formerly Hox-7 . 1) is expressed at high levels in uterine epithelial cells of the non-pregnant adult. These cells undergo pronounced changes in morphology in response to embryo implantation and show...

...-2 protein in the developing and adult nervous systems. bcl-2 protein is widespread during embryonic development. Proliferating neuroepithelial cells of ventricular zones as well as the postmitotic cells of the cortical plate, cerebellum, hippocampus and spinal cord express bcl-2. Postnatally, bcl-2...

...Stephen Small; David N. Arnosti; Michael Levine ABSTRACT The even-skipped ( eve ) promoter contains a series of enhancers that control the expression of different seg-mentation stripes in the Drosophila embryo. The stripe 3 enhancer is located 1.7 kb upstream of the stripe 2 enhancer. Here we...

...Randy L. Bennett; F. Michael Hoffmann ABSTRACT Mutations in the Drosophila Abelson tyrosine kinase have pleiotropic effects late in development that lead to pupal lethality or adults with a reduced life span, reduced fecundity and rough eyes. We have examined the expression of the abl protein...

... of Biologists 1992 Xenopus basic fibroblast growth factor induction mesoderm bFGF expression Determination of both the dorsal-ventral and anterior-posterior embryonic axes are the first major steps in the development of an embryo. Genetic and molecular analyses in Drosophila have...

...Juan-Carlos Izpisùa-Belmonte; Pascal Dollé; Armand Renucci; Vincenzo Zappavigna; Hildegard Falkenstein; Denis Duboule We report the cloning, genomic localization, primary structure and developmental expression pattern of the novel mouse Hox-4 . 3 gene. This gene is located within the HOX-4(5...

... and has been shown to function as a homophilic and heterophilic cell adhesion molecule. We have studied the spatial and temporal expression of two cloned mouse CEA gene family members during development using Northern analyses and in situ hybridization. Transcripts detected by the mouse CEA probes...

... expression is observed. However, it is not known what positional cues instruct the neural tube to express genes in this restricted manner. We have cloned a murine homeobox-containing gene, Hox-2 . 9 , whose expression in the neural tube at E9.5 is restricted to a segment of the hindbrain known as rhombomere...

...Erzsebet A. Jonas; Alison M. Snape; Thomas D. Sargent ABSTRACT XK81A1 is a type I epidermal keratin gene expressed in early developmental stages of Xenopus ( Jonas et al . 1985 ). Fusion of the keratin promoter (-5900 to +26) to a human β globin gene led to fully epidermis-specific accumulation...

...Rashmi Kothary; Susan Clapoff; Susan Darling; Marc D. Perry; Laurence A. Moran; Janet Rossant ABSTRACT Transgenic mice have been generated that express the E. coli β-galactosidase gene under the control of the promoter from the mouse heat-shock gene, hsp68 . Sequences from -664 to +113 relative...

...B. K. Kay; L. M. Schwartz; U. Rutishauser; T. H. Qiu; H. B. Peng The neural cell adhesion molecule (N-CAM) is seen in the membrane of nerves and muscles from several vertebrate species. Using indirect immunofluorescence, we have examined the expression of this protein during embryonic...

... tissue of embryos, commencing at the late neural tube stage. Expression is totally dependent on an interaction between mesoderm and ectoderm during gastrulation and can be used as a marker of neural induction. XIF1 shows 94 % homology and XIF3 83 % homology to hamster vimentin at the amino acid level...