..., University of Utah, Salt Lake City, UT 84112, USA † Present address: Department of Cellular Biochemistry and Human Genetics,The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel 26 8 2005 ©2005. 2005 Pancreas Exocrine Acinar β-catenin Wnt The mammalian...

..., and represents a characteristic feature of exocrine pancreatic cancer. In developing mouse pancreas, targeted inactivation of Notch pathway components has defined a role for Notch in regulating early endocrine differentiation, but has been less informative with respect to a possible role for Notch in regulating...

.... When the E12.5 pancreatic epithelial rudiment is cultured in the presence of its surrounding mesenchyme, both morphogenesis and cytodifferentiation of the exocrine component of the pancreas are completely achieved, while only a few immature endocrine cells develop. The pancreatic rudiments grown...