.... ICI is an antagonist of ESR1 and ESR2, and is an agonist of G protein-coupled estrogen receptor 1 (GPER1). Ovaries cultured in ICI-containing medium recover from MOF and/or an absence of follicular compartmentalization ( Morohaku et al., 2016 ). To assess which receptor mediates abnormal follicle...

.... Mechanistically, LBH induces expression of key epithelial stem cell transcription factor ΔNp63 to promote a basal MaSC state and repress luminal differentiation genes, mainly that encoding estrogen receptor α ( Esr1 / ERα ). Collectively, these studies identify LBH as an essential regulator of basal MaSC...