..., homeostasis and disease. Here, we (1) create an atlas of the cell types observed in the normal adult human esophagus; (2) establish an ancestrally diverse biobank of in vitro esophagus tissue to interrogate homeostasis and injury; and (3) benchmark in vitro models using the adult human esophagus atlas. We...

... such as the esophagus. However, the molecular mechanisms regulating these progenitor activities in the esophagus remain to be elucidated. Here, we demonstrated that Yap is required for the proliferation of esophageal progenitor cells (EPCs) in the developing murine esophagus. We found that Yap deficiency reduces EPC...

...Eric T. Domyan; Elisabetta Ferretti; Kurt Throckmorton; Yuji Mishina; Silvia K. Nicolis; Xin Sun The mammalian foregut gives rise to the dorsally located esophagus and stomach and the ventrally located trachea and lung. Proper patterning and morphogenesis of the common foregut tube and its derived...

...Pavel Rodriguez; Susana Da Silva; Leif Oxburgh; Fan Wang; Brigid L. M. Hogan; Jianwen Que The stratification and differentiation of the epidermis are known to involve the precise control of multiple signaling pathways. By contrast, little is known about the development of the mouse esophagus...

.... To investigate Sulf regulation of developmental signaling, we have disrupted Sulf genes in mouse and identified redundant functions of Sulfs in GDNF-dependent neural innervation and enteric glial formation in the esophagus, resulting in esophageal contractile malfunction in Sulf1 -/- ;Sulf2 -/- mice. SULF1...

... of the Foxp1/2/4 family in tissues where they are co-expressed. * Author for correspondence (e-mail: [email protected] ) 5 3 2007 © 2007. 2007 Foxp1 Foxp2 Lung development Esophagus T1alpha (podoplanin) Mouse The foregut endoderm is derived from the early...

... that MRFs are not involved in the process of initiation of developmentally programmed transdifferentiation in the esophagus. To investigate smooth- to-skeletal esophageal muscle transition, we analyzed Myf5nlacZ knock-in mice, MyoD- lacZ and myogenin- lacZ transgenic embryos with a panel of the antibodies...