...Paul E. Constanthin; Alessandro Contestabile; Volodymyr Petrenko; Charles Quairiaux; Patrick Salmon; Petra S. Hüppi; Jozsef Z. Kiss ABSTRACT Erythropoietin (EPO), the hypoxia-inducible hematopoietic hormone, has well-established neuroprotective/neurotrophic roles in the developing central nervous...

... for this process. We found that hepatic expression of erythropoietin (EPO), a secreted factor implicated in myocardial expansion, is dependent on both Raldh2 and Rxra . Chromatin immunoprecipitation studies support Epo as a direct target of RA signaling in embryonic liver. Treatment of an epicardial cell line...

...Xiaobing Yu; John J. Shacka; Jeffrey B. Eells; Carlos Suarez-Quian; Ronald M. Przygodzki; Bojana Beleslin-Cokic; Chyuan-Sheng Lin; Vera M. Nikodem; Barbara Hempstead; Kathleen C. Flanders; Frank Costantini; Constance Tom Noguchi Erythropoietin, known for its role in erythroid differentiation, has...

... in erythropoiesis. The antibody inhibited the stromal cell-dependent large colony formation of the erythroid progenitors. In the culture of erythropoietin-responsive erythroid progenitors of the anemia-inducing Friend virus-infected mouse spleen, the antibody inhibited only proliferation, but not differentiation...

... in the presence of erythropoietin. A large erythroid colony of over 1000 benzidine-positive erythroid cells was developed from a single erythroid progenitor cell on the FLS cell layer after 4 days of culture. When in close contact with the layer, the erythroid progenitor cells divided rapidly with an average...

...Hiroaki Fukumoto Yasuhisa Matsui; Masuo Obinata Erythropoietin is a well-known erythroid differentiation and growth factor, but the mechanism of its action is not well understood. In this work, we have examined its mechanism of action on the erythropoietin-responsive murine erythroleukemia cells...