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Keywords: Erythropoiesis
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Journal Articles
Journal: Development
Development (2020) 147 (22): dev185116.
Published: 15 November 2020
..., including alas2 , band3 , hbae1 , hbae3 and hbbe1 . Hif3α recognized the hypoxia response element located in the promoter of gata1 and directly bound to the promoter to transactivate gata1 expression. Our results suggested that hif3 a facilities hypoxia tolerance by modulating erythropoiesis via gata1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev164103.
Published: 21 March 2019
... erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 ( bif1 ). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous , another fish, and in the mouse genome. Both genes also inhibit BMP signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 430–440.
Published: 1 February 2017
... development in the early embryo. Even when expressed as a heterozygote, the Nan-EKLF protein accomplishes this by direct binding and aberrant activation of genes encoding secreted factors that exert a negative effect on erythropoiesis and iron use. Our data form the basis for a novel mechanism...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 493–500.
Published: 1 February 2008
.... Importantly, Brm deficiency does not exacerbate the erythropoietic or vascular abnormalities found in Brg1 fl/fl :Tie2-Cre + embryos, implying that Brg1 -containing SWI/SNF-like complexes, rather than Brm -containing complexes, play a crucial role in primitive erythropoiesis and in early vascular development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (5): 925–934.
Published: 1 March 2005
... receptors TRα and TRβ, which are transcription factors. Using mutant mice lacking TRs or deficient for TH production, we show that T3 influences neonatal erythropoiesis through TRα. The effect of T3 and TRα is restricted to this developmental window and is specific for the spleen but not for other...
Journal Articles
Journal: Development
Development (2004) 131 (13): 3183–3193.
Published: 1 July 2004
...Laura Gutiérrez; Fokke Lindeboom; An Langeveld; Frank Grosveld; Sjaak Philipsen; David Whyatt Gata1 is a transcription factor essential for erythropoiesis. Erythroid cells lacking Gata1 undergo apoptosis, while overexpression of Gata1 results in a block in erythroid differentiation. However...
Journal Articles
Journal: Development
Development (2003) 130 (25): 6187–6199.
Published: 22 December 2003
..., heart and somitic paraxial mesoderm territories. This restriction correlates well with activation of gata1 transcription and co-injection of gata1 mRNA along with scl/tal1 and lmo2 induces erythropoiesis more broadly without ventralising or posteriorising the embryo. While no ectopic myeloid development...
Journal Articles
Journal: Development
Development (2002) 129 (2): 539–549.
Published: 15 January 2002
... ; Ray and Wharton, 2001 ; Zon, 2001 ). Embryoid body Erythropoiesis EKLF GATA1 Serum-free media References Anderson, K. P., Crable, S. C. and Lingrel, J. B. ( 1998 ). Multiple proteins binding to a GATA-E box-GATA motif regulate the erythroid Kruppel-like factor (EKLF) gene. J...