..., including alas2 , band3 , hbae1 , hbae3 and hbbe1 . Hif3α recognized the hypoxia response element located in the promoter of gata1 and directly bound to the promoter to transactivate gata1 expression. Our results suggested that hif3 a facilities hypoxia tolerance by modulating erythropoiesis via gata1...

... erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 ( bif1 ). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous , another fish, and in the mouse genome. Both genes also inhibit BMP signaling...

... development in the early embryo. Even when expressed as a heterozygote, the Nan-EKLF protein accomplishes this by direct binding and aberrant activation of genes encoding secreted factors that exert a negative effect on erythropoiesis and iron use. Our data form the basis for a novel mechanism...

.... Importantly, Brm deficiency does not exacerbate the erythropoietic or vascular abnormalities found in Brg1 fl/fl :Tie2-Cre + embryos, implying that Brg1 -containing SWI/SNF-like complexes, rather than Brm -containing complexes, play a crucial role in primitive erythropoiesis and in early vascular development...

... receptors TRα and TRβ, which are transcription factors. Using mutant mice lacking TRs or deficient for TH production, we show that T3 influences neonatal erythropoiesis through TRα. The effect of T3 and TRα is restricted to this developmental window and is specific for the spleen but not for other...

...Laura Gutiérrez; Fokke Lindeboom; An Langeveld; Frank Grosveld; Sjaak Philipsen; David Whyatt Gata1 is a transcription factor essential for erythropoiesis. Erythroid cells lacking Gata1 undergo apoptosis, while overexpression of Gata1 results in a block in erythroid differentiation. However...

..., heart and somitic paraxial mesoderm territories. This restriction correlates well with activation of gata1 transcription and co-injection of gata1 mRNA along with scl/tal1 and lmo2 induces erythropoiesis more broadly without ventralising or posteriorising the embryo. While no ectopic myeloid development...

... for this purpose and compared with EB formation in 15% FBS. *Author for correspondence (e-mail: [email protected] ) 26 10 2001 © 2002. 2002 Embryoid body Erythropoiesis EKLF GATA1 Serum-free media Erythroid cells are one of eight distinct blood cell lineages derived from...

... marrow might be the result of a fast turnover of late red blood cell precursors and accelerated erythropoiesis in response to tissue hypoxia. The increase in cell death of late erythroid cells is independent from the proapoptotic factor Bax, as demonstrated in conditional double mutant mice for Bcl-x...

... in red blood cell differentiation. This non-autonomous function of cloche in red blood cell differentiation may reflect its cell-autonomous requirement in the endothelial lineage. Thus, cloche appears to be required in erythropoiesis cell non-autonomously at a step prior to gata-1 expression, and cell...

... extrinsically via angiogenesis from the adjacent yolk sac or fetus. Whether allantoic vasculogenesis is associated with erythropoiesis was also investigated. Benzidine-staining in situ revealed that primitive erythroid cells were not identified in the allantois until 6-somite pairs when continuity between its...

... to formation of an optic cup. Deficient cellular proliferation in the forebrain results in hypoplasia of the neocortex and aplasia of the hippocampal anlagen. In addition to the central nervous system malformations, a cell non-autonomous defect of definitive erythropoiesis causes severe anemia in Lhx2...

... by Company of Biologists 1997 allantois mouse lateral plate mesoderm paraxial mesoderm potency extraembryonic mesoderm primordial germ cells angioblasts vasculogenesis erythropoiesis Extraembryonic mesoderm is the first mesoderm formed during murine gastrulation. Epiblast cells from...

... locus control region β-globin lacZ gene basic promoter erythropoiesis embryonic expression pattern DNaseI hypersensitive sites transgenic mice mouse The locus control region (LCR) of the human β -globin multi-gene cluster is a cis-acting regulatory element present 5-25 kb upstream...

... of Chicago, Chicago, IL 60637, USA 27 09 1994 © 1995 by Company of Biologists 1995 hematopoiesis erythropoiesis GATA factors targeted mutations chimeric mice The differentiation of mature blood cell types from the multipotential hemopoietic stem cell appears...

... of tadpoles during metamorphosis. The histological analysis shows that erythrocytes differentiate only in ventral fragments, suggesting that the ventral blood islands and most likely also the dorsolateral mesoderm are the primary sites of erythropoiesis. We also demonstrate that the first generations...

....1041290104 Lipton , J. M. and Nathan , D. G. ( 1983 ). Cell-cell interactions in the regulation of erythropoiesis . Br. J. Haematol . 53 , 361 – 367 . 10.1111/j.1365-2141.1983.tb02036.x Metcalf , D. and Moore , M. A. S. ( 1971 ). Embryonic aspects of haemopoiesis...

...Joan Kessel; Barry Fabian ABSTRACT We use a standing-drop culturing method to investigate the effect on mesodermal erythropoiesis of ectoderm and endoderm from the .area opaca vasculosa (AOV) and area pellucida (AP) of stage-4 chick blastoderms. We find that ectoderm from the AOV and ectoderm...