... limbs, and its inhibition must prevent regeneration. Here, we show that the neuronally secreted protein Neuregulin-1 (NRG1) fulfills all these criteria in the axolotl. Immunohistochemistry and in situ hybridization of NRG1 and its active receptor ErbB2 revealed that they are expressed in regenerating...

... of these protrusions in trabeculation-deficient animals, including erbb2 mutants, tnnt2a morphants, which lack cardiac contractions and flow, and myh6 morphants, which lack atrial contraction and exhibit reduced flow. We found that, compared with cardiomyocytes in wild-type hearts, those in erbb2 mutants were less...

... sheet-like projections. Although it has been suggested that cardiac trabeculae enhance cardiac contractility and intra-ventricular conduction, their exact function in heart development has not been directly addressed. We found that in zebrafish erbb2 mutants, which we show completely lack cardiac...

.... * Author for correspondence (e-mail: [email protected] ) 11 6 2008 © 2008. 2008 ErbB2 ErbB3 Neuregulin Dorsal root ganglion Neural crest migration Zebrafish Segmentally reiterated dorsal root ganglia (DRGs) are required for vertebrates to sense and respond...

...Richard Chan; W. Rod Hardy; David Dankort; Michael A. Laing; William J. Muller We have generated a series of Erbb2 cDNA knock-in animals to explore the role of signaling pathways coupled to Erbb2 during development. Although this knock-in allele was hypomorphic, expressing tenfold less Erbb2...

...Marco Leu; Elena Bellmunt; Martin Schwander; Isabel Fariñas; Hans Rudolf Brenner; Ulrich Müller Neuregulins and their Erbb receptors have been implicated in neuromuscular synapse formation by regulating gene expression in subsynaptic nuclei. To analyze the function of Erbb2 in this process, we...

...Sharon L. Erickson; K. Sue O’Shea; Nazli Ghaboosi; Linda Loverro; Gretchen Frantz; Michelle Bauer; Lucy H. Lu; Mark W. Moore ABSTRACT Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor. We have...

... * These authors contributed equally to the work 26 06 1997 © 1997 by Company of Biologists 1997 erbB2 erbB3 and erbB4 receptors neural crest Schwann cells glia mouse The neuregulin gene encodes various isoforms of a recently identified growth and differentiation factor, which...