...-mail: [email protected] ) * These authors contributed equally to this work 4 9 2008 © 2008. 2008 FGF Heart development Outflow tract Second heart field Autocrine signaling Epithelial-mesenchymal transformation Mouse Many congenital heart defects are caused...

... and dysregulated epithelial-mesenchymal transformation (EMT). Interestingly, vascular endothelial growth factor A (Vegfa) levels in the hearts of Hhex –/– mice were elevated as much as three-fold between E9.5 and E11.5, and treatment of cultured Hhex –/– AV explants with truncated soluble Vegfa receptor 1, sFlt-1...

...Dazhong Sun; Charles R. Vanderburg; Gregory S. Odierna; Elizabeth D. Hay ABSTRACT Epithelial-mesenchymal transformation plays an important role in the disappearance of the midline line epithelial seam in rodent palate, leading to confluence of the palate. The aim of this study was to test...

...C. May Griffith; Elizabeth D. Hay ABSTRACT During the fusion of rodent embryo palatal shelves, the cells of the outer epithelial layer slough off, allowing the cells of the medial edge basal layer to form a midline seam that undergoes epithelial-mesenchymal transformation, as judged by electron...

... epithelial-mesenchymal transformation mouse embryo cardiogenesis It is becoming increasingly clear that polypeptide growth factors play a central role in many embryonic processes. Not only are these molecules and their receptors present within the early embryo in vivo ( Twardzik et al . 1982...

..., that of the anterior lens, gives rise to freely migrating mesenchyme-like cells when suspended in type I collagen matrices. Here, we show that a highly differentiated epithelium that expresses cytokeratin changes to a vimentin cytoskeleton and loses thyroglobulin during epithelial-mesenchymal transformation induced...