... differentiation of posterior follicle cells in Drosophila oogenesis. The mechanisms by which Drp1 regulates epithelial polarity during differentiation are not known. In this study, we show that Drp1-depleted follicle cells are constricted in early stages and present in multiple layers at later stages...

... without globally changing Su(H) occupancy. Notch and Scribble cooperate though transcription factor modules, including Pdp1. Notch signaling Drosophila Epithelial polarity Neoplasia Medical Research Council http://dx.doi.org/10.13039/501100007155 MR/L007177/1 Ligue Contre...

... the spatial restriction of the activin response in the context of the polarized epithelium. Huntington's disease Human embryonic stem cells 2D gastruloids TGFβ signaling Epithelial polarity CHDI Foundation http://dx.doi.org/10.13039/100005725 A-9423 Despite the fact that HD has...

... confers apical identity, Par-complex assembly and Crb accumulation to promote epithelial morphogenesis. Epithelial polarity Cdc42 Par6 Par3 Bazooka aPKC Crumbs Par complex Medical Research Council MC_UU_12018/3 MC_UU_00012/3 Epithelial cell polarity and morphogenesis...

... domain, which emerges together with the basal and lateral domains. Drosophila Cortical domains Epithelial domains Epithelial polarity Subapical F-actin Small GTPase Guanyl nucleotide exchange factor Cellularization Ced-12 China Scholarship Council 10.13039/501100004543...

... elongation. Epithelial polarity E-cadherin Membrane traffic AP-1 Caenorhabditis   elegans Adherens junctions and their essential component E-cadherin (E-cad) play a key role in maintaining the integrity of epithelia and preventing epithelium-mesenchyme transitions. Many studies have...

...Joaquim Grego-Bessa; Jeffrey Hildebrand; Kathryn V. Anderson The genetic control of mammalian epithelial polarity and dynamics can be studied in vivo at cellular resolution during morphogenesis of the mouse neural tube. The mouse neural plate is a simple epithelium that is transformed...

... by The Company of Biologists Ltd 2013 ArhGEF18 Medaka Retina Rho signaling Teleost Epithelial polarity Epithelial sheets are essential for the development of many vertebrate organs, including the central nervous system and retina. Epithelial cells are highly polarized along...

... polarize around a central lumen, provides a simple system with which to understand the coordination of epithelial polarity. We show that cell fate regulators cause pharyngeal precursor cells to group into a bilaterally symmetric, rectangular array of cells called the double plate. The double plate cells...

... adaptor AP-1 in the C. elegans intestine, we found that AP-1 is required for epithelial polarity maintenance. Depletion of AP-1 subunits does not affect epithelial polarity establishment or the formation of the intestinal lumen. However, the loss of AP-1 affects the polarised distribution of both apical...

.... Of particular interest is the relationship between genes that regulate neural patterning and the positioning and shaping of the ventricles, the interaction of nok with other genes that regulate epithelial polarity, and the mechanism by which atp1a1a.1 and other genes regulate lumen inflation...

... the apicalisation caused by aPKC . We conclude that an instrumental antagonistic interaction between aPKC and Lgl2 defines apicobasal polarity in early vertebrate development. 15 12 2004 ©2005. 2005 aPKC Crumbs Lgl Epithelial polarity Xenopus * Author for correspondence (e...

... pathway. Clones for null alleles of Pvr or expression of RNAi constructs showed no phenotypes in the wing disc or pupal wing, suggesting that Pvr plays a redundant role in this tissue. However, when uniform expression of a constitutively dimerizing receptor was induced, loss of epithelial polarity...

... Oriented cell division Neurogenesis Competence aPKC Par proteins Epithelial polarity Occludin The late blastula Xenopus embryo is shielded from the exterior by one layer of superficial cells that provide a tight-junction mediated epithelial seal. Underneath this superficial layer...

... division epithelial polarity Drosophila Asymmetric cell division operates in many developmental contexts to create two differently fated cells from a single progenitor cell (reviewed by Horvitz and Herskowitz, 1992 ). This process can result from extrinsic signals that instruct equivalent...

...John K. Lee; Eric Brandin; Daniel Branton; Lawrence S. B. Goldstein ABSTRACT To understand the role of the spectrin-based membrane skeleton in generating epithelial polarity, we characterized the distribution of membrane skeletal components in Drosophila ovarian follicle cells and in somatic clones...