...Jean Paul Thiery; Guojun Sheng; Xiaodong Shu; Raymond Runyan ABSTRACT Epithelial-mesenchymal transition (EMT) and its reverse mechanism, mesenchymal-epithelial transition (MET), are evolutionarily conserved mechanisms initially identified in studies of early metazoan development. EMT may even have...

... with a conditional packaging system . J. Virol. 72 , 8463 - 8471 . 10.1128/JVI.72.11.8463-8471.1998 Durgan , J. , Kaji , N. , Jin , D. and Hall , A. ( 2011 ). Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis . J. Biol. Chem. 286...

... of the corresponding genes. Using this approach, we generated endogenously tagged alleles for several genes that are crucial for epithelial biology and organ development, including the tight junction components ZO-1 and Cldn15la, the trafficking effector Rab11a, the apical polarity protein aPKC and the ECM receptor...

...Kyra Campbell; Jordi Casanova During development, cells often switch between static and migratory behaviours. Such transitions are fundamental events in development and are linked to harmful consequences in pathology. It has long been considered that epithelial cells either migrate collectively...

...Annita Achilleos; Ann M. Wehman; Jeremy Nance The apicobasal polarity of epithelial cells is critical for organ morphogenesis and function, and loss of polarity can promote tumorigenesis. Most epithelial cells form when precursor cells receive a polarization cue, develop distinct apical...

.... Arrows, actin in underlying muscles; arrowheads, epidermal cell-cell junctions. ( E-J )DIC (top) and GFP fluorescence (bottom) pictures of adults, illustrating expression in sensory support cells of the head (E,F), vulval cells (G,H) and rectal cells (I,J), which are epithelial. Scale bars: 10 μm. Fig...

... root formation, the preodontoblasts had NGFR-IR but most root mesenchymal cells and Hertwig’s epithelial root sheath did not. This work suggests that there are important epithelial and mesenchymal targets of NGF regulation during molar morphogenesis that differ for crown and root development...

...E. Jane Ormerod; Philip S. Rudland ABSTRACT Rat mammary ducts, free of buds, can alone regenerate complete mammary trees when transplanted into the interscapular fat pads of syngeneic host rats. All the main mammary cell types are identified within such outgrowths. Epithelial cells, which show...