...Murugesan Pooranachithra; Erin M. Jyo; Nicolas Brouilly; Nathalie Pujol; Andreas M. Ernst; Andrew D. Chisholm ABSTRACT The apical extracellular matrix (aECM) of external epithelia often contains lipid-rich outer layers that contribute to permeability barrier function. The external aECM of nematodes...

... in delayed embryonic lethality, partial tissue fusion rescue, and restoration of tissue form within the craniofacial epithelia. These data suggest that aberrant epithelial maintenance, partially regulated by noggin-mediated regulation of BMP-SMAD pathways, may underpin tissue fusion defects in Grhl2 −/− mice...

... of cell extrusion/cell death events in large movies of epithelia marked with cell contour. The pipeline, initially trained on movies of the Drosophila pupal notum marked with fluorescent E-cadherin, is easily trainable, provides fast and accurate extrusion predictions in a large range of imaging...

... typically powered by the contractile actomyosin cytoskeleton. This has been investigated mainly in homogeneous epithelia, where intercalation takes minutes. However, in some tissues, intercalation involves different cell types and can take hours. Whether slow and fast intercalation share the same mechanisms...

... Summary: This Primer explains and provides advice on two- and three-dimensional stress inference, an increasingly popular technique to identify the role of mechanics during embryo development. Mechanical stress inference Cell junction tension Cell pressure Cell shape Epithelia Development...

...Benoit Aigouy; Claudio Cortes; Shanda Liu; Benjamin Prud'Homme ABSTRACT Epithelia are dynamic tissues that self-remodel during their development. During morphogenesis, the tissue-scale organization of epithelia is obtained through a sum of individual contributions of the cells constituting...

... of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary:   Drosophila caspase 9 (Dronc), which is spatio-temporally activated in a non-apoptotic context, delays epithelial closure and may be involved in ROS generation. Drosophila Epithelia Live imaging Thorax closure...

... cue for setting up the apical-basal polarity axis, is regulated by active Rap1 acting both through, and independently of, the Cno Rap1-binding domain. Cadherin Cell adhesion Morphogenesis Epithelia Polarity Canoe/Afadin, Drosophila National Institutes of Health 10.13039...

... Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: Single-cell sequencing combined with a battery of molecular tools reveals novel features of cellular dynamics and differentiation during lacrimal gland development in mice. Lacrimal gland Epithelia Single cell...

... of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Summary: A combination of experimental work and theory reveals how gradients in transcription, signaling and resulting contractility shape tissue folding. Epithelia Fold Gradient Myosin Twist National Institutes...

... species. Image segmentation Cell tracking Planar polarity Epithelia Morphogenesis Convergent extension Drosophila Changes in epithelial organization are essential for tissue development, regeneration and repair. Advances in microscopy have made it possible to visualize dynamic...

... is not required in the wing disc because there are parallel mechanisms for Mud localization and hence spindle orientation, making it a more robust system than in other epithelia. References Basto , R. , Brunk , K. , Vinadogrova , T. , Peel , N. , Franz , A. , Khodjakov...

...Myrto Deligiannaki; Abbie L. Casper; Christophe Jung; Ulrike Gaul Epithelial sheets play essential roles as selective barriers insulating the body from the environment and establishing distinct chemical compartments within it. In invertebrate epithelia, septate junctions (SJs) consist of large...

... show that loss of Cα, the predominant C-terminal p63 variant in epithelia, promotes the transcriptional activity of TAp63 and also impairs the dominant-negative activity of ΔNp63, thereby controlling p21 Waf1/Cip1 expression. We propose that the p63 C-terminus links cell cycle control...

... transitions have focused on the cell-autonomous changes, while less is known about the role of neighboring epithelial cells in facilitating such transitions. Caenorhabditis elegans EMT Delamination Epithelia Junction Ras © 2014. Published by The Company of Biologists Ltd 2014 29 4...

...Lara C. Skwarek; Sarah L. Windler; Geert de Vreede; Gregory C. Rogers; David Bilder The Par-3/Par-6/aPKC complex is the primary determinant of apical polarity in epithelia across animal species, but how the activity of this complex is restricted to allow polarization of the basolateral domain...

... no competing financial interests. 11 11 2013 13 5 2014 © 2014. Published by The Company of Biologists Ltd 2014 Drosophila Endocytosis Epithelia Polarity Retromer The polarized distribution of proteins is central to biological function. Foundational work has identified...

...Sonia Hall; Courtney Bone; Kenzi Oshima; Liang Zhang; Molly McGraw; Bethany Lucas; Richard G. Fehon; Robert E. Ward, IV Polarized epithelia play crucial roles as barriers to the outside environment and enable the formation of specialized compartments for organs to carry out essential functions...

[email protected] ; [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Tubulogenesis Endothelia Epithelia Morphogenesis Lumen Tubes are the fundamental...

..., it is still unclear how adherens junctions are positioned at the interface of apical and basolateral domains in epithelia. Combining computational models with experiments has led to great progress in understanding cell polarity in yeast budding, the worm zygote and fly follicular epithelium. Other cell...