... proliferation. Macrophages have been shown to be essential for regeneration in salamanders and fish, but their role has not been elucidated in mammalian epimorphic regeneration. Here, using the regenerating mouse digit tip as a mammalian model, we demonstrate that macrophages are essential for the regeneration...

... signaling has been implicated in scar formation after wounding. During axolotl limb regeneration, differential regulation of Smad effectors may explain why these animals do not scar. Axolotl Epimorphic Regeneration TGF-β signaling Smad2 Smad3 Limb Salamander Urodeles A mbystoma mexicanum...