... Transcriptome Epigenome For many reasons, relatively little is known about human preimplantation development. The small number of cells makes embryos of any species difficult to study. In humans, the technical difficulties are compounded by other challenges. Genetic variation among individuals could...

... model for bivalency. In contrast, we propose that Mll2 is the pioneer trimethyltransferase for promoter definition in the naïve epigenome and that Polycomb group action on bivalent promoters blocks the premature establishment of active, Set1C-bound, promoters. ‡ Authors for correspondence...

[email protected] ) Competing interests statement 23 7 2010 © 2010. CHRAC Chromosome Epigenome Histone modification Nucleosome remodelling Drosophila The differentiation of cell identities during embryogenesis involves a step-wise diversification...