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Keywords: Epigenetics
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Journal Articles
Journal: Development
Development (2022) 149 (5): dev200076.
Published: 4 March 2022
... pathways and a battery of transcription factors. However, the contribution of epigenetic cues to hypothalamus development remains unclear. We mutated the polycomb repressor complex 2 gene Eed in the developing mouse hypothalamus, which resulted in the loss of H3K27me3, a fundamental epigenetic repressor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200250.
Published: 11 February 2022
... Neurogenesis Epigenetics Genomics Gene regulation Transcription factors Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 TI 799/1-3 Queen's University Belfast http://dx.doi.org/10.13039/501100000873 The brain is the most complex organ that has...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev200118.
Published: 20 January 2022
... for managing the accessibility of genome regulatory elements controlling gene expression profiles during development. Chromatin Development Enhancers Global repression Epigenetics Pioneer factors Israel Science Foundation http://dx.doi.org/10.13039/501100003977 Rosetrees Trust...
Journal Articles
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Reproductive biology
Journal: Development
Development (2021) 148 (24): dev200191.
Published: 21 December 2021
.... Together, our results show that although Dppa2/4 are dispensable for ZGA transcription, maternal stores have an important role in offspring survival, potentially via epigenetic priming of developmental genes. References Alda-Catalinas , C. , Bredikhin , D. , Hernando-Herraez , I...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev182667.
Published: 29 April 2021
... observational methods, whereas perturbational approaches have lacked precision. CRISPR-Cas9 has begun to transform the study of gene regulation, allowing for precise manipulation of genomic sequences, epigenetic functionalization and gene expression. CRISPR-Cas9 technology has already led to the discovery...
Journal Articles
Journal: Development
Development (2021) 148 (6): dev197202.
Published: 15 March 2021
... Enhancers Epigenetics Forebrain development Ribonucleoprotein complex Transcription factor binding Gene repression Ultraconserved elements (UCEs) were identified as 200 bp (or greater) segments of 100% DNA conservation between humans, mice and rats, many associated with key developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2021) 148 (3): dev196600.
Published: 10 February 2021
...Brandon S. Carpenter; Teresa W. Lee; Caroline F. Plott; Juan D. Rodriguez; Jovan S. Brockett; Dexter A. Myrick; David J. Katz ABSTRACT Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev188516.
Published: 4 December 2020
... SUV420H2 regulates embryonic stem (ES) cell fate by patterning the epigenetic landscape. Here, we report that depletion of SUV420H2 leads to a near-complete loss of H4K20me3 genome wide, dysregulated gene expression and delayed ES cell differentiation. SUV420H2-bound regions are enriched with repetitive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev190637.
Published: 7 August 2020
... components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans . Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... is suppressed within the developing testis by the presence of H3K27me3 on these same sites. Thus, we resolved sexually dimorphic regulation of Irx3 and Irx5 via epigenetic and β-catenin transcriptional control where their ovarian presence promotes oocyte and follicle survival vital for future ovarian health...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (6): dev175703.
Published: 18 March 2020
... and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control...
Journal Articles
Journal: Development
Development (2020) 147 (6): dev185629.
Published: 17 March 2020
... with significant epigenetic changes. Notably, we identify a cohort of differentially methylated regions (DMRs), most of which gain DNA methylation between the early and late stages of decidualisation. These DMRs are enriched at progesterone-responsive gene loci that are essential for reproductive function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
... or rewiring pluripotency networks. Recent innovations in chromatin and nuclear structure analyses combined with classical genetics have led to novel insights into the transcriptional and epigenetic mechanisms underlying these networks. Here, we review these findings in relation to their impact...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev181180.
Published: 20 September 2019
... the H3K9me3 mark is established and maintained, and the modes by which it functions to regulate gene expression and cell identity during development. Chromatin Heterochromatin Epigenetics Gene regulation Transcriptional repression Transposons Germline Cell fate maintenance In eukaryotic...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev170266.
Published: 10 July 2019
...Michelle K. Y. Seah; Yaju Wang; Pierre-Alexis Goy; Hui Mun Loh; Wen Jun Peh; Diana H. P. Low; Brenda Y. Han; Esther Wong; Ei Leen Leong; Gernot Wolf; Slim Mzoughi; Heike Wollmann; Todd S. Macfarlan; Ernesto Guccione; Daniel M. Messerschmidt ABSTRACT Global epigenetic reprogramming is vital to purge...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev167080.
Published: 19 March 2019
... Epigenetics Cell signaling Differentiation Skeletal muscle owes its considerable regenerative capacity to a population of resident muscle stem cells called satellite cells ( Lepper et al., 2011 ; McCarthy et al., 2011 ; Murphy et al., 2011 ; Sambasivan et al., 2011 ). These cells, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev165027.
Published: 27 November 2018
...://www.biologists.com/user-licence-1-1/ Summary: Temporal recruitment of Polycomb-group proteins at a target gene as they assume control of transcriptional repression that is initiated by a gene-specific transcription factor. Polycomb giant Epigenetics Midblastula transition Polycomb group...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev157149.
Published: 18 July 2018
...Le Zhang; Sandrine Ettou; Myda Khalid; Mary Taglienti; Dhawal Jain; Youngsook L. Jung; Catherine Seager; Yongqing Liu; Kar-Hui Ng; Peter J. Park; Jordan A. Kreidberg ABSTRACT Epigenetic regulation of gene expression has a crucial role allowing for the self-renewal and differentiation of stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev146589.
Published: 8 June 2018
... or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev153619.
Published: 18 May 2018
... of nephrogenesis. Histone deacetylases (HDACs) are a group of epigenetic regulators that control cell fate, but their role in balancing NPC renewal and differentiation is unknown. Here, we report that NPC-specific deletion of Hdac1 and Hdac2 genes in mice results in early postnatal lethality owing to renal...
Includes: Supplementary data