... Epigenetics National Science Foundation http://dx.doi.org/10.13039/100000001 R35HL145249 2UO1HL098162 Congenital heart disease (CHD), a structural abnormality of the heart and/or great vessels, is the most common cause of mortality from congenital malformations. Genetic variants...

... Rougeulle (Université Paris Cité/CNRS, Epigenetics and Cell Fate Center, Paris, France), Edda Schulz (Max Planck Institute for Molecular Genetics, Berlin, Germany) and James Turner (The Francis Crick Institute, London, UK). Originally scheduled for 2021, to commemorate the 60th anniversary of Mary Lyon's...

... Summary: This Review discusses the chromatin modifications associated with the mammalian female inactive X chromosome and their relevance to gene silencing and potential for therapeutic modulation. X inactivation Epigenetics Female Gene silencing Stem cells National Health and Medical...

... elements, that repetitive elements can function as a nuclear sink for epigenetic factors and that competition for H2A.Z greatly influences overall transcriptional output during development. These findings uncover general mechanisms in which counteractive biological processes underlie phenotypic outcomes...

... of existing sink occupation or by varying the size of the source, providing a central mechanism to explain a plethora of epigenetic phenomena, which contribute to phenotypic variegation, zygotic genome activation and nucleolar dominance. * Authors for correspondence ( Patrick_Murphy@urmc.rochester.edu...

... it is not only an output, but also a driver of cellular functions, such as cell proliferation and maturation. Finally, we underscore the epigenetic and cellular mechanisms by which metabolic switches mediate biosynthetic needs during development and regeneration, and how understanding these mechanisms...

... metabolites that, in addition to serving as energy sources, contribute to epigenetic modifications. * Authors for correspondence ( zhgene@zju.edu.cn ; jinglez@126.com ) Competing interests The authors declare no competing or financial interests. © 2023. Published by The Company...

... between histone modifications and developmental processes is challenging. In this Review, we discuss the use of dominant-negative histone mutations as tractable tools to study histone methylation in development. Chromatin Epigenetics Histone modification Stem cell Differentiation...

.... Maternal-fetal exchange Fetal development Programming Prenatal Extracellular vesicles Epigenetics A person's susceptibility to developing diseases such as diabetes and hypertension was previously thought to be determined by the interaction between genes and environment in adult life. However...

... is reprogrammed into a wing through inappropriate formation of the Vestigial–Scalloped complex. Drosophila Polycomb Vestigial Scalloped Eye Wing Imaginal disc Epigenetics Indiana University http://dx.doi.org/10.13039/100006733 National Eye Institute http://dx.doi.org/10.13039...

... pathways and a battery of transcription factors. However, the contribution of epigenetic cues to hypothalamus development remains unclear. We mutated the polycomb repressor complex 2 gene Eed in the developing mouse hypothalamus, which resulted in the loss of H3K27me3, a fundamental epigenetic repressor...

... signalling pathways, DNA-binding TFs and epigenetic machinery. In this study, we investigated how a pro-neural pioneer TF, NeuroD1, functions at a genome-wide level to induce active chromatin and gene expression, and coordinate specific cellular events during corticogenesis through its interaction...

... transcription factors, distal regulatory sequences are opened up by targeted epigenetic drivers that bring about site-specific local demethylation, thus stabilizing the inaccessible chromatin state and enabling a wide range of cis-trans interactions that can modulate the expression of associated genes ( Zaret...

.... Together, our results show that although Dppa2/4 are dispensable for ZGA transcription, maternal stores have an important role in offspring survival, potentially via epigenetic priming of developmental genes. To determine more globally whether there are any defects in ZGA, we performed single-embryo RNA...

... observational methods, whereas perturbational approaches have lacked precision. CRISPR-Cas9 has begun to transform the study of gene regulation, allowing for precise manipulation of genomic sequences, epigenetic functionalization and gene expression. CRISPR-Cas9 technology has already led to the discovery...

... Epigenetics Forebrain development Ribonucleoprotein complex Transcription factor binding Gene repression Ultraconserved elements (UCEs) were identified as 200 bp (or greater) segments of 100% DNA conservation between humans, mice and rats, many associated with key developmental regulators...

...Brandon S. Carpenter; Teresa W. Lee; Caroline F. Plott; Juan D. Rodriguez; Jovan S. Brockett; Dexter A. Myrick; David J. Katz ABSTRACT Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays...

... SUV420H2 regulates embryonic stem (ES) cell fate by patterning the epigenetic landscape. Here, we report that depletion of SUV420H2 leads to a near-complete loss of H4K20me3 genome wide, dysregulated gene expression and delayed ES cell differentiation. SUV420H2-bound regions are enriched with repetitive...

... components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans . Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated...

... is suppressed within the developing testis by the presence of H3K27me3 on these same sites. Thus, we resolved sexually dimorphic regulation of Irx3 and Irx5 via epigenetic and β-catenin transcriptional control where their ovarian presence promotes oocyte and follicle survival vital for future ovarian health...