1-20 of 82
Keywords: Epigenetics
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2021) 148 (9): dev182667.
Published: 29 April 2021
... observational methods, whereas perturbational approaches have lacked precision. CRISPR-Cas9 has begun to transform the study of gene regulation, allowing for precise manipulation of genomic sequences, epigenetic functionalization and gene expression. CRISPR-Cas9 technology has already led to the discovery of...
Journal Articles
Journal: Development
Development (2021) 148 (6): dev197202.
Published: 15 March 2021
..., localization, site-specific Sox2 recruitment and DNA binding. lncRNA Chromosome 3D structure Architectural proteins Enhancers Epigenetics Forebrain development Ribonucleoprotein complex Transcription factor binding Gene repression Ultraconserved elements (UCEs) were identified as 200 bp...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev196600.
Published: 10 February 2021
...Brandon S. Carpenter; Teresa W. Lee; Caroline F. Plott; Juan D. Rodriguez; Jovan S. Brockett; Dexter A. Myrick; David J. Katz ABSTRACT Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev188516.
Published: 04 December 2020
... SUV420H2 regulates embryonic stem (ES) cell fate by patterning the epigenetic landscape. Here, we report that depletion of SUV420H2 leads to a near-complete loss of H4K20me3 genome wide, dysregulated gene expression and delayed ES cell differentiation. SUV420H2-bound regions are enriched with repetitive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev190637.
Published: 07 August 2020
... components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans . Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... suppressed within the developing testis by the presence of H3K27me3 on these same sites. Thus, we resolved sexually dimorphic regulation of Irx3 and Irx5 via epigenetic and β-catenin transcriptional control where their ovarian presence promotes oocyte and follicle survival vital for future ovarian health...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev175703.
Published: 18 March 2020
... animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control of...
Journal Articles
Journal: Development
Development (2020) 147 (6): dev185629.
Published: 17 March 2020
... significant epigenetic changes. Notably, we identify a cohort of differentially methylated regions (DMRs), most of which gain DNA methylation between the early and late stages of decidualisation. These DMRs are enriched at progesterone-responsive gene loci that are essential for reproductive function. In...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
... rewiring pluripotency networks. Recent innovations in chromatin and nuclear structure analyses combined with classical genetics have led to novel insights into the transcriptional and epigenetic mechanisms underlying these networks. Here, we review these findings in relation to their impact on the...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev181180.
Published: 20 September 2019
.... S. , Zueva , E. , Cammas , F. , Schreiber , H. A. , Masson , V. , Belz , G. T. , Roche , D. , Maison , C. , Quivy , J.-P. , Almouzni , G. , et al. ( 2012 ). An epigenetic silencing pathway controlling T helper 2 cell lineage commitment . Nature   487 , 249...
Journal Articles
Journal: Development
Development (2019) 146 (19): dev170266.
Published: 10 July 2019
...Michelle K. Y. Seah; Yaju Wang; Pierre-Alexis Goy; Hui Mun Loh; Wen Jun Peh; Diana H. P. Low; Brenda Y. Han; Esther Wong; Ei Leen Leong; Gernot Wolf; Slim Mzoughi; Heike Wollmann; Todd S. Macfarlan; Ernesto Guccione; Daniel M. Messerschmidt ABSTRACT Global epigenetic reprogramming is vital to purge...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev167080.
Published: 19 March 2019
... Skeletal muscle Transcription factors Epigenetics Cell signaling Differentiation Skeletal muscle owes its considerable regenerative capacity to a population of resident muscle stem cells called satellite cells ( Lepper et al., 2011 ; McCarthy et al., 2011 ; Murphy et al., 2011 ; Sambasivan...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev165027.
Published: 27 November 2018
...://www.biologists.com/user-licence-1-1/ Summary: Temporal recruitment of Polycomb-group proteins at a target gene as they assume control of transcriptional repression that is initiated by a gene-specific transcription factor. Polycomb giant Epigenetics Midblastula transition Polycomb group...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev157149.
Published: 18 July 2018
...Le Zhang; Sandrine Ettou; Myda Khalid; Mary Taglienti; Dhawal Jain; Youngsook L. Jung; Catherine Seager; Yongqing Liu; Kar-Hui Ng; Peter J. Park; Jordan A. Kreidberg ABSTRACT Epigenetic regulation of gene expression has a crucial role allowing for the self-renewal and differentiation of stem and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev146589.
Published: 08 June 2018
... or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev153619.
Published: 18 May 2018
... nephrogenesis. Histone deacetylases (HDACs) are a group of epigenetic regulators that control cell fate, but their role in balancing NPC renewal and differentiation is unknown. Here, we report that NPC-specific deletion of Hdac1 and Hdac2 genes in mice results in early postnatal lethality owing to renal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev137729.
Published: 22 March 2018
... ). Epigenetic silencing of miR-181c by DNA methylation in glioblastoma cell lines . BMC Cancer   16 , 226 . 10.1186/s12885-016-2273-6 Balakrishnan , S. K. , Witcher , M. , Berggren , T. W. and Emerson , B. M. ( 2012 ). Functional and molecular characterization of the role of CTCF in...
Journal Articles
Journal: Development
Development (2017) 144 (24): 4510–4521.
Published: 15 December 2017
... functions as an epigenetic regulator of chondrogenesis through its recruitment of p100/CBP complexes . PLoS Genet.   11 , e1005680 . 10.1371/journal.pgen.1005680 Carrieri , C. , Cimatti , L. , Biagioli , M. , Beugnet , A. , Zucchelli , S. , Fedele , S. , Pesce , E...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4496–4509.
Published: 15 December 2017
... Embryogenesis Epigenetics Pluripotency Reprogramming Transcription Pluripotent cells reside naturally in the blastocyst of early mouse and human embryos and constitute the founder tissue of the embryo proper. Pluripotent stem cells (PSCs) that are capable of long-term self-renewal can be derived...
Journal Articles
Journal: Development
Development (2017) 144 (20): 3633–3645.
Published: 15 October 2017
... and stem cells and discuss the interest and potential importance of this concept with regard to epigenetic regulation and cell fate transitions involving cellular proliferation. * These authors contributed equally to this work ‡ Author for correspondence ( pnavarro@pasteur.fr...