...Tao He; Yu Fan; Juan Du; Mengyuan Yi; Yajuan Li; Min Liu; Alan Jian Zhu ABSTRACT Evolutionarily conserved Notch signaling is highly sensitive to changes in Notch receptor dose caused by intrinsic and environmental fluctuations. It is well known that epigenetic regulation responds dynamically...

... regulation Exencephaly Gastrulation Lung maturation The lysine methylation status of the histone 3 tail is central to epigenetic regulation, pivoting on methylation of lysines at positions 4, 9, 27 and 36. All active RNA polymerase II (Pol II) promoters are characterized by trimethylation...

... H2A.Z.2 in fate allocation and subsequent commitment of melanocyte identity, from a multipotent state. Histone variant Melanocyte Gene regulatory network Epigenetic regulation Fate-bias Specification Pigmentation Council for Scientific and Industrial Research 10.13039/501100001332...

... upregulates genes specifically expressed in precartilaginous condensations and well-known early-cartilage markers, but only partially contributes to the initiation of chromatin remodeling at precartilage and early-cartilage loci. Chondrogenesis Epigenetic regulation Pioneer transcription factor...

... Spermatogenesis Epigenetic regulation X inactivation Male fertility Meiosis During spermatogenesis in a variety of Metazoan species, the sex chromosomes undergo a large-scale chromatin remodeling event unique to male germ cells, termed meiotic sex chromosome inactivation (MSCI) ( Lifschytz...

... catalyst for such collaborative interactions, perhaps inspiring research directions that will reveal new principles of transcriptional and epigenetic regulation of cellular fate. Another crucial aspect of cellular reprogramming for regenerative purposes is the ‘quality’ of the resulting engineered...

... this limited program of gene activation. One key issue is how such sequence-specific gene activation is achieved towards the acquisition of pluripotency in early mouse embryos. Long noncoding RNA DNA demethylation Early mouse preimplantation development Zygotic gene activation Epigenetic regulation...

... expressed in our analyses have been shown to be regulated by the concerted action of the Polycomb (PcG) and Trithorax (TrxG) groups of epigenetic regulators ( supplementary material Table S2 ) ( Cui et al., 2009 ; Schuettengruber et al., 2007 ). Moreover, a large fraction of the genes that were...

... on epigenetic regulation that keeps in check inhibitors of an osteochondrogenic differentiation program. § Author for correspondence ( [email protected] ) * Present address: Helmholtz Zentrum, 85764 Neuherberg, Germany. ‡ These authors contributed equally to this work Competing...

..., the precise mechanisms by which CAF-1 mediates gene activation and whether CAF-1 specifically regulates gene expression in association with a particular developmental pathway remain unclear. Here, we report a novel function of dCAF-1 in epigenetically regulating the Notch signaling pathway. Our results show...

.... In addition to their well-established function in cell cycle control, it is becoming increasingly apparent that mammalian Cdks, cyclins and CKIs play indispensable roles in processes such as transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions and spermatogenesis. Even...

... ) Competing interests statement The authors declare no competing financial interests. 8 5 2012 © 2012. 2012 Histone demethylation Epigenetic regulation JMJD3 (Kdm6b) Smad3 TGFβ pathway Neurogenesis Epigenetic mechanisms that regulate access to the genetic material govern...

... ( [email protected] ) Competing interests statement 21 6 2010 © 2010. Neural development BMP pathway Epigenetic regulation Histone methylation EZH2 JMJD3 Chick neural tube During embryogenesis, multipotent neuroepithelial precursor cells originate...

... synergistically. * Author for correspondence (e-mail: [email protected] ) 16 5 2008 © 2008. 2008 Trithorax Polycomb Epigenetic regulation Maintenance elements Homeotic genes Two large gene families, the trithorax group (trxG) and the Polycomb group(PcG), are required...

...-like gene family Photoperiodic flowering Epigenetic regulation Rice The developmental process leading to flowering comprises a vegetative stage and a reproductive stage. The shoot apical meristem (SAM) gives rise to the vegetative structures, eventually transitioning to the reproductive...

... neurons in the epigenetic regulation of radial glial cell function in vivo. 15 02 1995 © 1995 by Company of Biologists 1995 transcription epigenetic regulation radial glia Bergmann glia enhancer silencer mammal brain lipid-binding protein Finally, it is of interest...