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Keywords: Epigenetic control
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Journal Articles

Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation

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Sang-Hoon Yi, Xi-Biao He, Yong-Hee Rhee, Chang-Hwan Park, Takumi Takizawa, Kinichi Nakashima, Sang-Hun Lee
Journal: Development
Development (2014) 141 (4): 761–772.
https://doi.org/10.1242/dev.095802
Published: 15 February 2014
... are not dopaminergic, probably owing to the repressive role of CoREST-Hdac1. Jacobs and colleagues (Jacobs et al., 2009b) have reported another epigenetic control mechanism mediated by the Nurr1 activator Pitx3, in which Pitx3 potentiates Nurr1-induced DA gene expression by releasing an Smrt (Ncor1 - Mouse Genome...
View articletitled, Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation
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Includes: Supplementary data
Journal Articles

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development

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Siok-Lay Tan, Miyuki Nishi, Toshiyuki Ohtsuka, Toshiyuki Matsui, Keiko Takemoto, Asuka Kamio-Miura, Hiroyuki Aburatani, Yoichi Shinkai, Ryoichiro Kageyama
Journal: Development
Development (2012) 139 (20): 3806–3816.
https://doi.org/10.1242/dev.082198
Published: 15 October 2012
... by epigenetic control, such as histone modification, although the precise mechanism is unknown. Here we found that ESET (Setdb1), a histone H3 Lys9 (H3K9) methyltransferase, is highly expressed at early stages of mouse brain development but downregulated over time, and that ablation of ESET leads to decreased...
View articletitled, Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development
Open the PDF for Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development in another window
Includes: Supplementary data