.... Summary: Set1 maintains germline activity by ensuring proper JAK-STAT and BMP signaling in the Drosophila testis. Germline stem cell Maintenance Differentiation Chromatin Histone modification Epigenetic Signaling pathway Gene expression National Institutes of Health http...

... evidence that distinct epigenetic and transcriptional regulatory mechanisms operate across emerging embryonic cell types. These datasets and analyses, as well as the approach we devised, are expected to facilitate the discovery of molecular mechanisms underlying pattern formation in plant embryos...

..., which can be an acquired rather than a hardwired intrinsic property. In this Review, we summarise the recent findings into how ISC identity can be defined by proliferation state, signalling crosstalk, epigenetics and metabolism, and propose an update on the hallmarks of ISCs. We further discuss how...

...Raz Ben-Yair; Vincent L. Butty; Michele Busby; Yutong Qiu; Stuart S. Levine; Alon Goren; Laurie A. Boyer; C. Geoffrey Burns; Caroline E. Burns ABSTRACT Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal...

... understood. Here, we demonstrate that cell-extrinsic factors coordinate with the epigenetic regulator high-mobility group AT-hook 2 ( Hmga2 ) to regulate self-renewal of late retinal progenitor cells (RPCs). We observed that a small subset of RPCs was capable of clonal propagation and retained...

...Robert A. Drewell; Eliot C. Bush; Emily J. Remnant; Garrett T. Wong; Suzannah M. Beeler; Jessica L. Stringham; Julianne Lim; Benjamin P. Oldroyd In honey bees ( Apis mellifera ), the epigenetic mark of DNA methylation is central to the developmental regulation of caste differentiation, but may also...

... Competence Polycomb Epigenetic Cell fate specification requires the coordination of inductive signals and progenitor cell competence to respond to such signals. Temporal regulation of progenitor competence is particularly important during nervous system development ( Pearson and Doe, 2004...

..., the deletion surprisingly did not affect the differential DNA methylation of the locus, which displayed an appropriate epigenetic switch in the parental germlines. Furthermore, the characteristic asynchronous pattern of DNA replication at H19 was also not disrupted by the deletion, suggesting...

...) cells affects their totipotency and may give rise to fetal abnormalities. To investigate whether this is associated with epigenetic alterations in imprinted genes, we analysed two maternally expressed genes ( Igf2r, H19 ) and two paternally expressed genes ( Igf2, U2af1-rs1 ) in ES cells...