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Keywords: Epiboly
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Journal Articles
Journal: Development
Development (2019) 146 (1): dev169664.
Published: 02 January 2019
..., fixed embryos at 75% epiboly and stained them using an HA antibody ( Campbell et al., 2015 ; Nojima et al., 2010 ). We observed HA staining around migrating e-YSN as well as in the cytoplasm ( Fig. 5 C). To address dynein localization, we used the fluorescent tag on the interfering construct, as...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155366.
Published: 09 January 2018
... nanog (maternal and zygotic null) mutant zebrafish embryos . Without functional Nanog, epiboly is severely affected, embryo axes do not form and massive cell death starts at the end of gastrulation. We show that three independent defects in MZ nanog mutants contribute to epiboly failure: yolk...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4266–4276.
Published: 15 October 2013
.... Expression of FF in the animal cap revealed a previously unidentified role of FAK in early morphogenesis and specifically epiboly. We show that a fibronectin-derived signal transduced by FAK governs polarity and cell intercalation. Finally, failure of epiboly results in severe gastrulation problems that can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (7): 1296–1305.
Published: 01 April 2012
... initiate epiboly, which can be rescued by re-expression of 2-OST protein. Reduced cell adhesion and altered cell cycle regulation in 2-OST-deficient embryos are associated with decreased β-catenin and E-cadherin protein levels at cell junctions, and these defects can be rescued by reactivation of the...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 537–546.
Published: 01 February 2012
... drive epiboly in early Danio rerio (zebrafish) development. We show that depletion of αE-catenin caused a defect in radial intercalation that was associated with decreased cell-cell adhesion, in a similar manner to E-cadherin depletion. Depletion of αE-catenin also caused deep cells to have protracted...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 383–392.
Published: 01 February 2009
...Filipa Carreira-Barbosa; Mihiko Kajita; Veronique Morel; Hironori Wada; Hitoshi Okamoto; Alfonso Martinez Arias; Yasuyuki Fujita; Stephen W. Wilson; Masazumi Tada During vertebrate gastrulation, the body axis is established by coordinated and directional movements of cells that include epiboly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (16): 2807–2813.
Published: 15 August 2008
... initiated after sphere stage (midway through the blastula period, 4 hpf) and occurs progressively until 50% epiboly[the onset of gastrulation, 5.3 hpf; see Kimmel et al.( Kimmel et al., 1995 ) for embryonic stages]. Notably, this cell behaviour predominantly occurs in a region of the dorsal blastoderm...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (5): 979–988.
Published: 01 March 2007
... maternally and in restricted cell types zygotically. Knockdown of amotl2 expression delays epiboly and impairs convergence and extension movement, and amotl2-deficient cells in mosaic embryos fail to migrate properly. This coincides with loss of membrane protrusions and disorder of F-actin. Amotl2 partially...
Journal Articles
Journal: Development
Development (2006) 133 (14): 2757–2770.
Published: 15 July 2006
... blastoderm-specific arrest of epiboly. Dorsal tissues expand to the ventral side at the expense of ventrolateral tissue in MZ spg embryos. Dorsally expressed Bmp-antagonists, such as Chd and Nog1, and Gsc are ectopically activated at ventral levels in MZ spg . Lack of ventral specification is apparent very...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (10): 1881–1890.
Published: 15 May 2006
... showed that FAM53B bound 14-3-3 chaperones, as well as SKIIP proteins, adaptor proteins connecting DNA-binding proteins to modulators of transcription. smp inactivation with morpholinos led to delayed epiboly and reduced embryonic size. Absence of Smp activity did not induce apoptosis, but resulted in a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (5): 1105–1116.
Published: 01 March 2005
...Donald A. Kane; Karen N. McFarland; Rachel M. Warga Epiboly, the spreading of the blastoderm over the large yolk cell, is the first morphogenetic movement of the teleost embryo. Examining this movement as a paradigm of vertebrate morphogenesis, we have focused on the epiboly arrest mutant half...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (5): 873–887.
Published: 01 March 2003
... provide for plasticity at this critical stage of early development. ‡ Author for correspondence (e-mail: rja46@cam.ac.uk ) 18 11 2002 © 2003. 2003 Gradients Morphogenesis no tail Mediolateral intercalation behavior Notochord Convergence Extension Gastrulation Epiboly...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2001) 128 (18): 3635–3647.
Published: 15 September 2001
... gastrulae injected with monoclonal antibodies directed against the central cell-binding domain of fibronectin. Among the defects observed is a disruption of fibronectin matrix assembly, resulting in a failure of radial intercalation movements, which are required for blastocoel roof thinning and epiboly. We...