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Keywords: Epiblast
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Journal Articles
Journal: Development
Development dev.199926.
Published: 15 October 2021
... both robust cell type proportioning despite variable initial conditions in the precursor cells, as well as the re-establishment of these proportions upon perturbations in a developing tissue remain to be characterised. Here we report that the differentiation of robust proportions of epiblast-like...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev183079.
Published: 22 July 2020
.... ( 2014 ). The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification . Nat. Cell Biol.   16 , 516 - 528 . 10.1038/ncb2965 Boroviak , T. , Loos , R. , Lombard , P. , Okahara , J. , Behr , R. , Sasaki , E...
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184960.
Published: 03 February 2020
...Sofiane Hamidi; Yukiko Nakaya; Hiroki Nagai; Cantas Alev; Takeya Kasukawa; Sapna Chhabra; Ruda Lee; Hitoshi Niwa; Aryeh Warmflash; Tatsuo Shibata; Guojun Sheng ABSTRACT The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at gastrulation, when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev172916.
Published: 03 April 2019
...Maria Rostovskaya; Giuliano G. Stirparo; Austin Smith ABSTRACT Human naïve pluripotent stem cells (PSCs) share features with the pre-implantation epiblast. They therefore provide an unmatched opportunity for characterising the developmental programme of pluripotency in Homo sapiens . Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (16): dev150433.
Published: 23 July 2018
... these studies, which suggest that the posterior epiblast and/or the nascent amnion in pregastrulation human embryos is a likely source of hPGCs, and that a different gene regulatory network controls PGCs in humans compared with in the mouse. Such studies on the origins and mechanisms of hPGC specification...
Journal Articles
Journal: Development
Development (2018) 145 (12): dev159103.
Published: 18 June 2018
... a conditional deletion system to investigate embryonic patterning and lineage specification in response to loss of Oct4. We first observe ectopic expression of Nanog in Oct4-negative postimplantation epiblast cells. The expression domains of lineage markers are subsequently disrupted. Definitive endoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3719–3730.
Published: 15 October 2017
...Anna Piliszek; Zofia E. Madeja; Berenika Plusa Formation of epiblast (EPI) – the founder line of all embryonic lineages – and extra-embryonic supportive tissues is one of the key events in mammalian development. The prevailing model of early mammalian development is based almost exclusively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3706–3718.
Published: 15 October 2017
... to the pluripotent epiblast (EPI), which forms the embryo proper, and the primitive endoderm (PrE), which forms extra-embryonic yolk sac tissues. All inner cells coexpress lineage markers such as Nanog and Gata6 at embryonic day (E) 3.25, and the EPI and PrE precursor cells eventually segregate to exclusively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1450–1461.
Published: 15 April 2017
...Mubeen Goolam; Magdalena Zernicka-Goetz The separation of embryonic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which will form the new organism, from the primitive endoderm (PE), which will form the yolk sac, is a crucial developmental decision. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1221–1234.
Published: 01 April 2017
... of early post-implantation epiblast and are distinct from primed epiblast. They also exhibit a genome-wide increase in DNA methylation, intermediate between early and late epiblast. These findings are consistent with the proposition that naïve cells transition to a distinct formative phase of pluripotency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 365–373.
Published: 01 February 2017
... formative pluripotency, exists between the naïve and primed states, and is enabling for the execution of pluripotency. Embryonic stem cells Pluripotency Epiblast Lineage specification Developmental potential Pluripotency may be defined as an intrinsic and flexible cellular potential...
Journal Articles
Journal: Development
Development (2017) 144 (2): 175–186.
Published: 15 January 2017
...Thorsten Boroviak; Jennifer Nichols ABSTRACT Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation embryo and fail to resume development in chimaeric assays. Recent data...
Journal Articles
Journal: Development
Development (2015) 142 (21): 3675–3685.
Published: 01 November 2015
...Audrey Laurent; Francesco Blasi Between implantation and gastrulation, mouse pluripotent epiblast cells expand enormously in number and exhibit a remarkable hypersensitivity to DNA damage. Upon low-dose irradiation, they undergo mitotic arrest followed by p53-dependent apoptosis, whereas the other...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3151–3165.
Published: 15 September 2015
... expressed in the human pluripotent epiblast, including the transcription factor KLF17 . Key components of the TGF-β signalling pathway, including NODAL , GDF3 , TGFBR1/ALK5 , LEFTY1 , SMAD2 , SMAD4 and TDGF1 , are also enriched in the human epiblast. Intriguingly, inhibition of TGF-β signalling abrogates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3637–3648.
Published: 01 October 2014
...Sylvain Bessonnard; Laurane De Mot; Didier Gonze; Manon Barriol; Cynthia Dennis; Albert Goldbeter; Geneviève Dupont; Claire Chazaud During blastocyst formation, inner cell mass (ICM) cells differentiate into either epiblast (Epi) or primitive endoderm (PrE) cells, labeled by Nanog and Gata6...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2173–2181.
Published: 01 June 2014
... , 189 - 204 . Brons I. G. M. , Smithers L. E. , Trotter M. W. B. , Rugg-Gunn P. , Sun B. , Chuva de Sousa Lopes S. M. , Howlett S. K. , Clarkson A. , Ahrlund-Richter L. , Pedersen R. A. , et al ( 2007 ). Derivation of pluripotent epiblast stem...
Journal Articles
Journal: Development
Development (2013) 140 (21): 4311–4322.
Published: 01 November 2013
...Néstor Saiz; Joanna B. Grabarek; Nitin Sabherwal; Nancy Papalopulu; Berenika Plusa During mouse pre-implantation development, extra-embryonic primitive endoderm (PrE) and pluripotent epiblast precursors are specified in the inner cell mass (ICM) of the early blastocyst in a ‘salt and pepper’ manner...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 965–975.
Published: 01 March 2013
... and WWTR1 showed mutually distinct localisation patterns that suggest non-redundant roles. NANOG and GATA6 were conserved as markers of epiblast and hypoblast, respectively, but some differences to the mouse were found in their mode of differentiation. Our results suggest that there is considerable...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 267–279.
Published: 15 January 2013
...Minjung Kang; Anna Piliszek; Jérôme Artus; Anna-Katerina Hadjantonakis The emergence of pluripotent epiblast (EPI) and primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves initial co-expression of lineage-associated markers followed by mutual exclusion...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 871–882.
Published: 01 March 2012
...Ewart W. Kuijk; Leni T. A. van Tol; Hilde Van de Velde; Richard Wubbolts; Maaike Welling; Niels Geijsen; Bernard A. J. Roelen At the blastocyst stage of mammalian pre-implantation development, three distinct cell lineages have formed: trophectoderm, hypoblast (primitive endoderm) and epiblast...