... Pigment cell EDNRB2 ET3 c-KIT EphB2 Ephrins Pathfinding Migration Chick Neural crest One way that signaling molecules influence embryonic patterning is by controlling cellular pathfinding. Neural crest cells (NCCs) are a good model system for studying pathfinding because they migrate...

... olivocerebellar system, EphA receptors and ephrin-As are expressed with distinct levels and combinations in mapping domains. When ephrin-A2 is retrovirally overexpressed in the cerebellum, the olivocerebellar map is disrupted, excluding axons with high receptor activity from ectopic expression domains. Conversely...

... dorsolaterally into the skin, whereas neural crest cells specified as melanoblasts are directed into the dorsolateral pathway. Eph receptors and their ephrin ligands have been shown to be essential for migration of many cell types during embryonic development. Consequently, we asked if ephrin-B proteins...

... connectivity may involve the combined activity of Eph proteins serving as guidance receptors and as axon guidance cues. *Authors for correspondence (e-mail: [email protected] or [email protected]) 11 5 2001 © 2001. 2001 Axon pathfinding Ephrins Extracellular domains Retinal...

... kinases on RGC axons and ephrin ligands on target cells have been implicated in formation of topographic maps. However, studies in chick and mouse have shown that both Eph receptors and ephrins are also expressed within the retina itself, raising the possibility that this receptor-ligand family mediates...

... of expression of Rpx/Hesx1, Wnt1, R-cadherin and ephrin-A2 in mutant cells, whereas expression of En2 and Six3 is rescued by surrounding wild-type cells. Forebrain Otx2 mutant cells subsequently undergo apoptosis. Altogether, this study demonstrates that Otx2 is an important regulator of brain patterning...

...Nigel Holder; Rüdiger Klein ABSTRACT Eph receptor tyrosine kinases and their ligands, the ephrins, appear to lie functionally at the interface between pattern formation and morphogenesis. We review the role of Eph and ephrin signalling in the formation of segmented structures, in the control...

...María Araujo; M. Elisa Piedra; M. Teresa Herrera; María A. Ros; M. Angela Nieto ABSTRACT Eph receptors and their ligands, the ephrins, have been implicated in early patterning and axon guidance in vertebrate embryos. Members of these families play pivotal roles in the formation of topographic maps...