... are prevented from intermingling with adjacent cells. In this study, we show that the Eph receptor gene ephb4b is highly expressed in DFCs whereas ephrin ligand genes, including efnb2b , are expressed in cells next to the DFC cluster during zebrafish gastrulation. ephb4b knockdown or mutation and efnb2b...

... CAKUT Eph Ephrin Nephric duct Vesicoureteric junction obstruction Mouse Congenital anomalies of the kidney and urinary tract (CAKUT) are amongst the most common human birth defects. They comprise a wide range of structural and functional malformations of the individual components...

... to altered refractive index and cataracts in humans and mice. References Abram C. L. , Courtneidge S. A. ( 2000 ). Src family tyrosine kinases and growth factor signaling . Exp. Cell Res. 254 , 1 – 13 . Arvanitis D. , Davy A. ( 2008 ). Eph/ephrin signaling: networks...

...Rüdiger Klein Eph receptors and their membrane-tethered ligands have important functions in development. Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration. Eph-ephrin signalling can be bi...

.... * Author for correspondence ( [email protected] ) Competing interests statement 30 9 2010 © 2010. Epithelium Stratification Polarity Branching Microlumen Tubulogenesis Plexus Remodeling Eph Ephrin Mouse The mature pancreas...

... of Fibronectin (FN) depends on the FN receptor Integrinα5β1. Using in vivo imaging and genetic mosaics, our studies suggest that incipient Itgα5 clustering along the nascent border precedes matrix formation and is independent of FN binding. Integrin clustering can be initiated by Eph/Ephrin signaling...

.... * Author for correspondence (e-mail: [email protected] ) 8 12 2008 © 2009. 2009 Sall Townes-Brocks syndrome Hox Limb development Shh Eph Mouse The development of the vertebrate limb has long served as an experimental and conceptual model system with which to study...

...Audrey Dufour; Joaquim Egea; Klas Kullander; Rüdiger Klein; Pierre Vanderhaeghen Ephrin/Eph ligands and receptors are best known for their prominent role in topographic mapping of neural connectivity. Despite the large amount of work centered on ephrin/Eph-dependent signaling pathways in various...

...Monica Boyle; Alan Nighorn; John B. Thomas The conserved Eph receptors and their Ephrin ligands regulate a number of developmental processes, including axon guidance. In contrast to the large vertebrate Eph/Ephrin family, Drosophila has a single Eph receptor and a single Ephrin ligand, both...

... 123 , 179 -190. Brennan, C., Monschau, B., Lindberg, R., Guthrie, B., Drescher,U., Bonhoeffer, F. and Holder, N. ( 1997 ). Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish. Development 124 , 655 -664...

...Bernd Knöll; Konstantinos Zarbalis; Wolfgang Wurst; Uwe Drescher ABSTRACT We have investigated the role of the Eph family of receptor tyrosine kinases and their ligands in the establishment of the vomeronasal projection in the mouse. Our data show intriguing differential expression patterns...

...Françoise Helmbacher; Sylvie Schneider-Maunoury; Piotr Topilko; Laurent Tiret; Patrick Charnay ABSTRACT The Eph family of tyrosine kinase receptors has recently been implicated in various processes involving the detection of environmental cues such as axonal guidance, targeted cell migration...

...María Araujo; M. Elisa Piedra; M. Teresa Herrera; María A. Ros; M. Angela Nieto ABSTRACT Eph receptors and their ligands, the ephrins, have been implicated in early patterning and axon guidance in vertebrate embryos. Members of these families play pivotal roles in the formation of topographic maps...

...K. Patel; R. Nittenberg; D. D’Souza; C. Irving; D. Burt; D. G. Wilkinson; C. Tickle ABSTRACT The Eph -related receptor tyrosine kinase gene, Cek-8 , is expressed in mesenchyme at the tip of chick limb buds, with high levels of transcripts posteriorly and apically but fading out anteriorly...

... regulation of cell identity and restriction of cell movement between segments. We have taken a dominant negative approach to interfere with the function of Sek-1, a member of the Eph-related receptor tyrosine kinase family expressed in rhombomeres r3 and r5. In Xenopus and zebrafish embryos expressing...