... homozygous deletions of the Tbx transcription factor brachyury or inducible expression of Eomes. Resulting chimeric gastruloids recapitulate reported Eomes and brachyury functions, such as instructing cardiac fate and promoting posterior axial extension, respectively. Additionally, chimeric gastruloids...

.... Genetic experiments indicate that both lineages segregate from Eomes -expressing progenitors in response to different Nodal signaling levels. However, the precise spatiotemporal pattern of the emergence of these cell types and molecular details of lineage segregation remain unexplored. We combined genetic...

... attributed. Highlighted article: In the developing chick pallium, a basal progenitor population resembles mammalian cortical basal radial glia, suggesting a more ancient evolutionary origin for this cell type. Tbr2 Eomes Gpsm2 Amniote Basal progenitor Evolution Pallium Chicken Mouse...

..., TEAD4 must activate other trophectoderm-specific genes in addition to Cdx2 . Since Eomes is down regulated in both Cdx2 -/- ( Strumpf et al., 2005 ) and Tead4 -/- embryos, Eomes is either directly or indirectly regulated by CDX2, which in turn, is regulated by TEAD4. Conversely, Fgfr2...

... temporarily overexpressed. For this purpose, we co-injected GFP.RN3 mRNA and mRNA for the early Xenopus gene Eomes , and found that a high concentration of Eomes results in ectopic muscle gene activation in only the injected cells. This marker may therefore be of general value in providing long term...