... results in death of specific posterior eCNm molecular subdomains and downregulation of TBR2 (EOMES) in an anterior embryonic subdomain, as well as reduced synaptic gene expression. We further reveal a similar function for EN1/2 in mediating TBR2 expression, neuron differentiation and survival in the other...

... homozygous deletions of the Tbx transcription factor brachyury or inducible expression of Eomes. Resulting chimeric gastruloids recapitulate reported Eomes and brachyury functions, such as instructing cardiac fate and promoting posterior axial extension, respectively. Additionally, chimeric gastruloids...

.... Genetic experiments indicate that both lineages segregate from Eomes -expressing progenitors in response to different Nodal signaling levels. However, the precise spatiotemporal pattern of the emergence of these cell types and molecular details of lineage segregation remain unexplored. We combined genetic...

... attributed. Highlighted article: In the developing chick pallium, a basal progenitor population resembles mammalian cortical basal radial glia, suggesting a more ancient evolutionary origin for this cell type. Tbr2 Eomes Gpsm2 Amniote Basal progenitor Evolution Pallium Chicken Mouse...

... of the trophectoderm lineage. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 8 8 2007 © 2007. 2007 Cdx2 Oct4 Eomes Embryonic stem cell Trophoblast stem cell Morula Blastocyst Cellular differentiation...

... temporarily overexpressed. For this purpose, we co-injected GFP.RN3 mRNA and mRNA for the early Xenopus gene Eomes , and found that a high concentration of Eomes results in ectopic muscle gene activation in only the injected cells. This marker may therefore be of general value in providing long term...