... Twist. We propose that Notch signaling targets two distinct `Repressors of twist' - the proteins encoded by the Enhancer of split complex[ E(spl)C ] and the HLH gene extra machrochaetae ( emc ). Hence, the patterning of Drosophila mesodermal segments relies on Notch signaling changing the activities...

...Judy Cossins; Ann E. Vernon; Yun Zhang; Anna Philpott; Philip H. Jones Hes6 is a basic helix-loop-helix transcription factor homologous to Drosophila Enhancer of Split (EoS) proteins. It is known to promote neural differentiation and to bind to Hes1, a related protein that is part of the Notch...

... of Notch and its downstream gene Enhancer of split-m β. The expression of extramacrochaetae at the dorso/ventral boundary and in boundary cells between veins and interveins depends on Notch activity. We propose that at least during vein differentiation and wing margin formation, extramacrochaetae...

... clonal analysis we show that a ligand of Notch, Delta, is required along with Notch for both proneural enhancement and lateral specification, while the downstream components Suppressor-of-Hairless and Enhancer-of-Split are involved only in lateral specification. Our data point to a distinct signal...

.... C. Lai and J. W. Posakony (1997) Development 124, 4039-4051) that the 3′ untranslated regions (UTRs) of many genes involved in Notch signalling, including Bearded (Brd) and the genes of the Enhancer of split Complex (E(spl)-C), contain (often in multiple copies) two novel heptanucleotide sequence...

... of Xenopus ESR-1 , a gene related to Drosophila Enhancer of split , appears to be induced by Notch signaling during this process. To determine how the activation of X-Notch-1 induces ESR-1 expression and regulates primary neurogenesis, we isolated the Xenopus homolog of Suppressor of Hairless ( X-Su(H...

...Jose F. de Celis; Jesus de Celis; Petros Ligoxygakis; Anette Preiss; Christos Delidakis; Sarah Bray ABSTRACT The basic helix-loop-helix proteins of the Enhancer of split complex constitute a link between activation of the transmembrane receptor Notch and the resulting effects on transcription...

... of an inhibitory signal, Delta, that is transduced through the Notch receptor and results in a cessation of achaete-scute activity. Here we show that mutation of either the bHLH-encoding genes of the Enhancer of split complex (E(spl)-C) or groucho , like Notch or Delta mutants, cause an overproduction of sensory...

...Amelia Y. Hartenstein; Astrid Rugendorff; Ulrich Tepass; Volker Hartenstein ABSTRACT The complex embryonic phenotype of the six neurogenic mutations Notch, mastermind, big brain, Delta, Enhancer of split and neuralized was analyzed by using different antibodies and P lac Z markers, which allowed us...

...Janice A. Fischer-Vize; Peter D. Vize; Gerald M. Rubin An unusual recessive allele of the Drosophila groucho gene, which encodes a transducinlike protein, affects the fates of specific cells in the eye disc groucho is one of several transcription units in the Enhancer of split complex. Most groucho...