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Keywords: Enhancer
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Journal Articles
Journal: Development
Development (2022) 149 (4): dev200133.
Published: 18 February 2022
... tissue, which in zebrafish enables subsequent regeneration through paracrine and vascularizing effects. To identify tissue regeneration enhancer elements (TREEs) that control injury-induced epicardial gene expression during heart regeneration, we profiled transcriptomes and chromatin accessibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200059.
Published: 15 December 2021
... upstream of T that is essential for notochord function and tailbud outgrowth. Within that region, we discovered a T-binding enhancer required for notochord cell specification and differentiation. Our data reveal a complex regulatory landscape controlling cell type-specific expression and function of T...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev198549.
Published: 30 April 2021
..., and is required for proper cone opsin regulation ( Roberts et al., 2005 ). We identified a potential CRM near the promoter of Rxrg . An enhancer, Rxrg208, active in chick photoreceptors and HCs, was previously identified within this peak ( Blixt and Hallböök, 2016 ) ( Fig. 4 B). We then asked whether ThrbCRM1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196113.
Published: 20 January 2021
... and Dorsal, which directly regulate target genes to pattern Drosophila embryos. The actions of these factors at enhancers has been thoroughly dissected and provides a rich platform for understanding direct input by morphogens and their changing roles over time. Importantly, Bicoid and Dorsal do not work...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194019.
Published: 23 December 2020
.... This dynamic transcriptional response relies on the activities of tissue regeneration enhancer elements (TREEs); however, the mechanisms underlying TREEs are poorly understood. We dissected a cardiac regeneration enhancer in zebrafish to elucidate the mechanisms governing spatiotemporal gene expression during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
... transcriptional upregulation by creating a synthetic endogenous operon, and identified an enhancer region that contains multiple LAG-1 binding sites (LBSs) embedded in a more extensively conserved high occupancy target (HOT) region. We show that these LBSs are necessary for upregulation in response to LIN-12...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... ovary. Using in silico analysis of ATAC- and ChIP-Seq databases in conjunction with mouse gonad explant transfection assays, we identified TCF/LEF-binding sequences within two distal enhancers of the IrxB locus that promote β-catenin-responsive ovary expression. Meanwhile, Irx3 and Irx5 transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev181909.
Published: 16 March 2020
... by regulating chromatin accessibility. Precocious expression of E93 early in wing development reveals that it can simultaneously activate and deactivate different target enhancers. Notably, the precocious patterns of enhancer activity resemble the wild-type patterns that occur later in development, suggesting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184432.
Published: 5 February 2020
.... A. , et al. ( 2015 ). MEF2D drives photoreceptor development through a genome-wide competition for tissue-specific enhancers . Neuron   86 , 247 - 263 . 10.1016/j.neuron.2015.02.038 Billings , N. A. , Emerson , M. M. and Cepko , C. L. ( 2010 ). Analysis of thyroid response...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev177063.
Published: 19 September 2019
... . J. Vis. Exp.   25 , e1229 . 10.3791/1229 Cannavò , E. , Khoueiry , P. , Garfield , D. A. , Geeleher , P. , Zichner , T. , Gustafson , E. H. , Ciglar , L. , Korbel , J. O. and Furlong , E. E. ( 2016 ). Shadow enhancers are pervasive features...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev170068.
Published: 7 March 2019
... that specify these progenitor fates remain unknown. To uncover the transcriptional networks that regulate Cux2 expression in the forebrain, we characterized a conserved Cux2 enhancer that recapitulates Cux2 expression specifically in the cortical hem. Using a bioinformatic approach, we identified putative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev160333.
Published: 23 February 2018
... an optimised, adaptable toolkit enabling genome and epigenome engineering in the chicken embryo, and demonstrate its utility by probing gene regulatory interactions mediated by neural crest enhancers. First, we optimise novel efficient guide-RNA mini expression vectors utilising chick U6 promoters, provide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3917–3931.
Published: 1 November 2017
... through binding to a distal enhancer. Finally, overexpression of E47 in embryonic NSCs in vitro impaired neurite outgrowth, and overexpression of E47 in vivo by in utero electroporation disturbed proper layer-specific neurogenesis and upregulated p57(KIP2) expression. Overall, this study identifies E2A...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3095–3101.
Published: 1 September 2017
...Justin Crocker; David L. Stern Transcriptional enhancers are regions of DNA that drive precise patterns of gene expression. Although many studies have elucidated how individual enhancers can evolve, most of this work has focused on what are called ‘minimal’ enhancers, the smallest DNA regions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2428–2444.
Published: 1 July 2017
... enhancer elements near these target genes. Functional experiments performed in vitro and in vivo confirm that this network of genes requires ERK, ERG and p300 activity. Finally, genome-editing and transgenic approaches demonstrate that a highly conserved ERG-bound enhancer located upstream of HLX (which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 2009–2020.
Published: 1 June 2017
... patella syndrome . Nat. Genet.   19 , 51 - 55 . 10.1038/ng0598-51 Chen , H. , Capellini , T. D. , Schoor , M. , Mortlock , D. P. , Reddi , A. H. and Kingsley , D. M. ( 2016 ). Heads, shoulders, elbows, knees, and toes: modular Gdf5 enhancers control different joints...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1249–1260.
Published: 1 April 2017
... regulatory elements that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have yet to be defined. Here, we identified three gene-proximal enhancer-like sequences (PSE_a, PSE_b and VPE) that faithfully activate tissue-specific expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4533–4542.
Published: 1 December 2016
... of transcription factors (TFs) converging on enhancer elements. Here, as a point of entry to dissect the poorly defined GRN underlying cardiomyocyte differentiation, we apply an integrated approach to identify active enhancers and TFs involved in Drosophila heart development. The Drosophila heart consists of 104...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3751–3762.
Published: 15 October 2016
...Yvonne C. Lussi; Luca Mariani; Carsten Friis; Juhani Peltonen; Toshia R. Myers; Claudia Krag; Garry Wong; Anna Elisabetta Salcini Methylation of histone 3 lysine 4 (H3K4) is largely associated with promoters and enhancers of actively transcribed genes and is finely regulated during development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3723–3732.
Published: 15 October 2016
... genes and enhancers. Analysis of Drosophila CNS midline cell development provides a useful system for studying transcriptional regulation at the genomic level due to a large, well-characterized set of midline-expressed genes and in vivo validated enhancers. In this study, FAIRE-seq on FACS-purified...
Includes: Supplementary data