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Keywords: Enhancer
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Journal Articles
Journal: Development
Development (2021) 148 (9): dev198549.
Published: 30 April 2021
... The Company of Biologists Ltd 2021 Summary: Genome-wide assays have led to the identification of many new cis -regulatory modules for genes important in cone development, showing that Otx2 and Oc have a broad role in this regulation. Cis -regulatory module CRM Enhancer Chromatin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196113.
Published: 20 January 2021
... and Dorsal, which directly regulate target genes to pattern Drosophila embryos. The actions of these factors at enhancers has been thoroughly dissected and provides a rich platform for understanding direct input by morphogens and their changing roles over time. Importantly, Bicoid and Dorsal do not...
Journal Articles
Journal: Development
Development (2020) 147 (24): dev194019.
Published: 23 December 2020
... dynamic transcriptional response relies on the activities of tissue regeneration enhancer elements (TREEs); however, the mechanisms underlying TREEs are poorly understood. We dissected a cardiac regeneration enhancer in zebrafish to elucidate the mechanisms governing spatiotemporal gene expression during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
... transcriptional upregulation by creating a synthetic endogenous operon, and identified an enhancer region that contains multiple LAG-1 binding sites (LBSs) embedded in a more extensively conserved high occupancy target (HOT) region. We show that these LBSs are necessary for upregulation in response to LIN-12...
Includes: Supplementary data
Journal Articles
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Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... ovary. Using in silico analysis of ATAC- and ChIP-Seq databases in conjunction with mouse gonad explant transfection assays, we identified TCF/LEF-binding sequences within two distal enhancers of the IrxB locus that promote β-catenin-responsive ovary expression. Meanwhile, Irx3 and Irx5 transcription is...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev181909.
Published: 16 March 2020
... regulating chromatin accessibility. Precocious expression of E93 early in wing development reveals that it can simultaneously activate and deactivate different target enhancers. Notably, the precocious patterns of enhancer activity resemble the wild-type patterns that occur later in development, suggesting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev184432.
Published: 05 February 2020
... authors declare no competing or financial interests. 10 9 2019 13 12 2019 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Non-coding RNA profiling identifies cell type-specific enhancer elements in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev177063.
Published: 19 September 2019
...: Genetic studies reveal that transcriptional autoregulation maintains the expression of tbx6 in the presomitic mesoderm of zebrafish embryos. Enhancer Somite segmentation T-box transcription factor Transcriptional regulation Zebrafish During embryogenesis, somites, bilateral epithelial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev170068.
Published: 07 March 2019
... that specify these progenitor fates remain unknown. To uncover the transcriptional networks that regulate Cux2 expression in the forebrain, we characterized a conserved Cux2 enhancer that recapitulates Cux2 expression specifically in the cortical hem. Using a bioinformatic approach, we identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev160333.
Published: 23 February 2018
... an optimised, adaptable toolkit enabling genome and epigenome engineering in the chicken embryo, and demonstrate its utility by probing gene regulatory interactions mediated by neural crest enhancers. First, we optimise novel efficient guide-RNA mini expression vectors utilising chick U6 promoters...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 3917–3931.
Published: 01 November 2017
... through binding to a distal enhancer. Finally, overexpression of E47 in embryonic NSCs in vitro impaired neurite outgrowth, and overexpression of E47 in vivo by in utero electroporation disturbed proper layer-specific neurogenesis and upregulated p57(KIP2) expression. Overall, this study identifies E2A...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3095–3101.
Published: 01 September 2017
...Justin Crocker; David L. Stern Transcriptional enhancers are regions of DNA that drive precise patterns of gene expression. Although many studies have elucidated how individual enhancers can evolve, most of this work has focused on what are called ‘minimal’ enhancers, the smallest DNA regions that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2428–2444.
Published: 01 July 2017
... putative enhancer elements near these target genes. Functional experiments performed in vitro and in vivo confirm that this network of genes requires ERK, ERG and p300 activity. Finally, genome-editing and transgenic approaches demonstrate that a highly conserved ERG-bound enhancer located upstream of HLX...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 2009–2020.
Published: 01 June 2017
... with Lmx1b-regulated genes during mouse limb development uncovers cis -regulatory modules and their gene targets involved in limb dorsal-ventral identity. Lmx1b Dorsal-ventral patterning Enhancer Limb Dorsalization Mouse The presence of morphologically distinguishable dorsal and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1249–1260.
Published: 01 April 2017
... regulatory elements that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have yet to be defined. Here, we identified three gene-proximal enhancer-like sequences (PSE_a, PSE_b and VPE) that faithfully activate tissue-specific expression in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4533–4542.
Published: 01 December 2016
... transcription factors (TFs) converging on enhancer elements. Here, as a point of entry to dissect the poorly defined GRN underlying cardiomyocyte differentiation, we apply an integrated approach to identify active enhancers and TFs involved in Drosophila heart development. The Drosophila heart consists of 104...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3751–3762.
Published: 15 October 2016
...Yvonne C. Lussi; Luca Mariani; Carsten Friis; Juhani Peltonen; Toshia R. Myers; Claudia Krag; Garry Wong; Anna Elisabetta Salcini Methylation of histone 3 lysine 4 (H3K4) is largely associated with promoters and enhancers of actively transcribed genes and is finely regulated during development by...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3723–3732.
Published: 15 October 2016
... genes and enhancers. Analysis of Drosophila CNS midline cell development provides a useful system for studying transcriptional regulation at the genomic level due to a large, well-characterized set of midline-expressed genes and in vivo validated enhancers. In this study, FAIRE-seq on FACS-purified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3074–3084.
Published: 01 September 2016
... embryonic stem cell (ESC) self-renewal, whether it is an essential pluripotency factor has been disputed. Here, we show that Sall4 is dispensable for mouse ESC pluripotency. Sall4 is an enhancer-binding protein that prevents precocious activation of the neural gene expression programme in ESCs but is not...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2994–3001.
Published: 15 August 2016
...Iain Williamson; Laura A. Lettice; Robert E. Hill; Wendy A. Bickmore Limb-specific Shh expression is regulated by the (∼1 Mb distant) ZRS enhancer. In the mouse, limb bud-restricted spatiotemporal Shh expression occurs from ∼E10 to E11.5 at the distal posterior margin and is essential for correct...
Includes: Supplementary data