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Keywords: Endothelium
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Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
... Epithelium Endothelium Neural crest Cell fate Cellular plasticity is of vital importance in development, disease and repair. One particular example of this plasticity, epithelial-to-mesenchymal transition (EMT), and its reverse, mesenchymal-to-epithelial transition (MET), is key to many stages of...
Journal Articles
Journal: Development
Development (2016) 143 (8): 1302–1312.
Published: 15 April 2016
...Laurent Yvernogeau; Rodolphe Gautier; Hanane Khoury; Sara Menegatti; Melanie Schmidt; Jean-Francois Gilles; Thierry Jaffredo Adult-type hematopoietic stem and progenitor cells are formed during ontogeny from a specialized subset of endothelium, termed the hemogenic endothelium, via an endothelial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3198–3209.
Published: 15 September 2015
... generated under conditions specifying anterior-like mesoderm, whereas blood-forming endothelium was generated from posterior-like mesoderm, and vessel-forming CD31 + endothelial cells were generated from all mesoderm origins. Surprisingly, inhibition of β-catenin signaling led to the highly efficient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2719–2724.
Published: 01 August 2015
.... References Bertrand , J. Y. , Chi , N. C. , Santoso , B. , Teng , S. , Stainier , D. Y. R. and Traver , D. ( 2010 ). Haematopoietic stem cells derive directly from aortic endothelium during development . Nature   464 , 108 - 111 . 10.1038/nature08738 Boisset , J.-C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2452–2463.
Published: 15 July 2015
... examined, including T-cell development, skin differentiation and carcinogenesis, the inner ear, the lung and the retina. We were able to show that phenotypes in the heart, endothelium, and marginal zone B cells are attributed to haploinsufficiency but not to intracellular domain composition. Tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4610–4617.
Published: 01 December 2014
... blood vessels are poorly understood. Here, we show that the histone methyltransferase Ezh2 maintains integrity of the developing vasculature by repressing a transcriptional program that activates expression of Mmp9 . Inactivation of Ezh2 in developing mouse endothelium caused embryonic lethality with...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4500–4512.
Published: 01 December 2014
... © 2014. Published by The Company of Biologists Ltd 2014 VEGF-C Angiogenesis Apelin receptor (APJ APLNR) Coronary vessel development Endothelium Sinus venosus Given the devastating effects of coronary heart disease, there is an important need to fully understand coronary artery...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1465–1472.
Published: 01 April 2014
... multiple integrins and reduces the activation state of β1 integrin. In vivo , the constitutive or inducible loss of Dnm2 in endothelium impairs branching morphogenesis and promotes the accumulation of β1 integrin at sites of failed angiogenic sprouting. Collectively, our data show that Dnm2 uncouples VEGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (10): 2172–2180.
Published: 15 May 2013
... regulation of gene expression, the implications of which are still incompletely understood. We focused on microRNA 21 (miR-21), which is expressed in cardiac valve endothelium during development, in order to better understand its mechanistic role in cardiac valve development. Using a combination of in vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (23): 4061–4072.
Published: 01 December 2010
... (PVM), but not in the endothelium of mice, leads to the hepatic defects associated with AGS. Loss of Jag1 expression in SM22α-positive cells of the PVM leads to defective bile duct development beyond the initial formation of the ductal plate. Cytokeratin 19-positive cells are detected surrounding the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (16): 2653–2657.
Published: 15 August 2010
... Competing interests statement 7 6 2010 © 2010. Lymphatic system Cell migration Endothelium Pattern formation Zebrafish The vertebrate blood vessels are crucial for the exchange of gases, hormones and metabolites, whereas lymphatic vessels are important in the...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2331–2338.
Published: 01 July 2008
... targeting to investigate the defects underlying the Lkb1 -/- phenotype. Endothelium-restricted deletion of Lkb1 led to embryonic death at E12.5 with a loss of vascular smooth muscle cells (vSMCs) and vascular disruption. Transforming growth factor beta(TGFβ) pathway activity was reduced in Lkb1 -deficient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1703–1712.
Published: 01 May 2007
... ascribed the property of regulating the expression of numerous endothelium-specific genes. However,the transcriptional regulatory hierarchy governing Gata2 activation in endothelial cells has not been fully explored. Here, we document GATA-2 endothelial expression during embryogenesis by following GFP...
Journal Articles
Journal: Development
Development (2006) 133 (6): 1013–1022.
Published: 15 March 2006
... mesoderm, we have traced the distribution of somite-derived endothelial cells during aortic hematopoiesis. We show that the aortic endothelium undergoes two successive waves of remodeling by somitic cells: one when the aortae are still paired, during which the initial roof and sides of the vessels are...
Journal Articles
Journal: Development
Development (2004) 131 (8): 1847–1857.
Published: 15 April 2004
... importance of different cellular sources of PDGFB has not been established. Using Cre-lox techniques, we show here that genetic ablation of Pdgfb in endothelial cells leads to impaired recruitment of pericytes to blood vessels. The endothelium-restricted Pdgfb knockout mutants also developed organ defects...
Journal Articles
Journal: Development
Development (2004) 131 (1): 37–55.
Published: 01 January 2004
... portion will become transformed into chorio-adhesive cells, and endothelial cells within the core. Formation of endothelium and chorio-adhesive cells begins in the distal region of the allantois, farthest from the streak. Over time, endothelium spreads to the proximal allantoic region, whilst the distal...
Journal Articles
Journal: Development
Development (2002) 129 (24): 5683–5695.
Published: 15 December 2002
... endothelial cells. However, the two populations give rise to distinct regions of the vasculature and are programmed differentially by BMP. † Author for correspondence (e-mail: roger.patient@nottingham.ac.uk ) 23 9 2002 ©2002. 2002 Blood Endothelium Haemangioblast BMP...
Journal Articles
Journal: Development
Development (2002) 129 (17): 4147–4157.
Published: 01 September 2002
... derivation of emerging hematopoietic stem cells from the vessel endothelium, endothelial cells have been sorted by flow cytometry from the yolk sac and aorta and cultured in the presence of stromal cells that support human multilineage hematopoiesis. Embryonic endothelial cells were most accurately selected...
Journal Articles
Journal: Development
Development (2002) 129 (12): 3009–3019.
Published: 15 June 2002
... number in specific cranial vessels. We show that vbg encodes activin receptor-like kinase 1 (Acvrl1; also known as Alk1), a TGFβ type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants. Thus, vbg provides a model for the human autosomal...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (11): 2773–2783.
Published: 01 June 2002
... correspondence (e-mail: p.bianco@flashnet.it and cossu.giulio@hsr.it ) 8 3 2002 © 2002. 2002 Stem cells Endothelium Pericyte Angiogenesis Chimera Mesoderm Histogenesis Mouse Quail Our current appreciation of stem cells plasticity has changed dramatically in the last years...