... membrane, confirming the cadherin-based adherens junction role of β-catenin. Furthermore, using a genetic model to block blood flow, we observed that cell junctions are compromised in most endothelial cells but not in the endocardium, highlighting the heterogeneous response of the endothelium to the lack...

... sequencing on isolated Cxcl12 -DsRed + endothelium to assess cellular heterogeneity within pulmonary endothelium. Combining cell annotation with gene ontology and histological analysis allowed us to segregate the developing artery endothelium into functionally and spatially distinct subpopulations...

... Endothelium National Institutes of Health http://dx.doi.org/10.13039/100000002 R01HL152293 R01HL158840 R01HL132996 Efficient gas exchange requires the coordinated development of the alveolar epithelium and mesenchyme during the neonatal stage ( Hogan et al., 2014 ; Mund et al., 2008...

... as they form. These include the corneal endothelium within the eye, the middle ear, the palate and the teeth. Fig. 2. EMT and MET in the vertebrate head. (A-C) The development of many structures within the vertebrate head involves either EMT or MET. These structures are often extremely specialised...

...Laurent Yvernogeau; Rodolphe Gautier; Hanane Khoury; Sara Menegatti; Melanie Schmidt; Jean-Francois Gilles; Thierry Jaffredo Adult-type hematopoietic stem and progenitor cells are formed during ontogeny from a specialized subset of endothelium, termed the hemogenic endothelium, via an endothelial...

... was generated under conditions specifying anterior-like mesoderm, whereas blood-forming endothelium was generated from posterior-like mesoderm, and vessel-forming CD31 + endothelial cells were generated from all mesoderm origins. Surprisingly, inhibition of β-catenin signaling led to the highly efficient...

...-cell level. Endothelium Imaging RUNX1 SOX17 Mice Human Hemogenic Hematopoiesis Endothelial-to-hematopoietic transition Scanning electron microscopy Endothelial-to-hematopoietic transition (EHT) during embryogenesis provides the first long-term hematopoietic stem and progenitor...

... examined, including T-cell development, skin differentiation and carcinogenesis, the inner ear, the lung and the retina. We were able to show that phenotypes in the heart, endothelium, and marginal zone B cells are attributed to haploinsufficiency but not to intracellular domain composition. Tissue...

... blood vessels are poorly understood. Here, we show that the histone methyltransferase Ezh2 maintains integrity of the developing vasculature by repressing a transcriptional program that activates expression of Mmp9 . Inactivation of Ezh2 in developing mouse endothelium caused embryonic lethality...

... role as a tissue-specific mediator of blood endothelial development. VEGF-C Angiogenesis Apelin receptor (APJ APLNR) Coronary vessel development Endothelium Sinus venosus Given the devastating effects of coronary heart disease, there is an important need to fully understand coronary...

... of multiple integrins and reduces the activation state of β1 integrin. In vivo , the constitutive or inducible loss of Dnm2 in endothelium impairs branching morphogenesis and promotes the accumulation of β1 integrin at sites of failed angiogenic sprouting. Collectively, our data show that Dnm2 uncouples VEGF...

... regulation of gene expression, the implications of which are still incompletely understood. We focused on microRNA 21 (miR-21), which is expressed in cardiac valve endothelium during development, in order to better understand its mechanistic role in cardiac valve development. Using a combination of in vivo...

...), but not in the endothelium of mice, leads to the hepatic defects associated with AGS. Loss of Jag1 expression in SM22α-positive cells of the PVM leads to defective bile duct development beyond the initial formation of the ductal plate. Cytokeratin 19-positive cells are detected surrounding the portal vein, yet...

... Competing interests statement 7 6 2010 © 2010. Lymphatic system Cell migration Endothelium Pattern formation Zebrafish The vertebrate blood vessels are crucial for the exchange of gases, hormones and metabolites, whereas lymphatic vessels are important...

... targeting to investigate the defects underlying the Lkb1 -/- phenotype. Endothelium-restricted deletion of Lkb1 led to embryonic death at E12.5 with a loss of vascular smooth muscle cells (vSMCs) and vascular disruption. Transforming growth factor beta(TGFβ) pathway activity was reduced in Lkb1 -deficient...

... ascribed the property of regulating the expression of numerous endothelium-specific genes. However,the transcriptional regulatory hierarchy governing Gata2 activation in endothelial cells has not been fully explored. Here, we document GATA-2 endothelial expression during embryogenesis by following GFP...

... mesoderm, we have traced the distribution of somite-derived endothelial cells during aortic hematopoiesis. We show that the aortic endothelium undergoes two successive waves of remodeling by somitic cells: one when the aortae are still paired, during which the initial roof and sides of the vessels...

... importance of different cellular sources of PDGFB has not been established. Using Cre-lox techniques, we show here that genetic ablation of Pdgfb in endothelial cells leads to impaired recruitment of pericytes to blood vessels. The endothelium-restricted Pdgfb knockout mutants also developed organ defects...

... portion will become transformed into chorio-adhesive cells, and endothelial cells within the core. Formation of endothelium and chorio-adhesive cells begins in the distal region of the allantois, farthest from the streak. Over time, endothelium spreads to the proximal allantoic region, whilst the distal...

... to endothelial cells. However, the two populations give rise to distinct regions of the vasculature and are programmed differentially by BMP. † Author for correspondence (e-mail: [email protected] ) 23 9 2002 ©2002. 2002 Blood Endothelium Haemangioblast BMP...