...-specific transcriptomes with expression changes in response to signaling perturbations demonstrates complex roles for Endothelin 1 (Edn1) signaling in the intermediate joint-forming region, yet a surprisingly minor role in ventralmost regions. Analysis of co-variance across multiple sequencing experiments...

.... The mandibular portion of pharyngeal arch 1 is patterned dorsally by Jagged-Notch signaling and ventrally by endothelin receptor A (EDNRA) signaling. Loss of EDNRA signaling disrupts normal ventral gene expression, the result of which is homeotic transformation of the mandible into a maxilla-like structure...

...Jianxin Hu; Michael P. Verzi; Ashley S. Robinson; Paul Ling-Fung Tang; Lisa L. Hua; Shan-Mei Xu; Pui-Yan Kwok; Brian L. Black Endothelin signaling is essential for neural crest development, and dysregulated Endothelin signaling is associated with several neural crest-related disorders, including...

... field and a dorsomedially located second heart field. It remains largely unknown when and how these subdivisions of the heart field divide into regions with different fates. Here, we identify in the mouse a subpopulation of the first (crescent-forming) field marked by endothelin receptor type A ( Ednra...

... melanocyte development. However, melanocytes in the eye,ear and harderian gland were revealed to be less sensitive to KIT signaling than cutaneous melanocytes. Instead, melanocytes in the eye and harderian gland were stimulated more effectively by endothelin 3 (ET3) or hepatocyte growth factor (HGF) signals...

...Takahiro Sato; Yumiko Kawamura; Rieko Asai; Tomokazu Amano; Yasunobu Uchijima; Dagmara A. Dettlaff-Swiercz; Stefan Offermanns; Yukiko Kurihara; Hiroki Kurihara The endothelin (Edn) system comprises three ligands (Edn1, Edn2 and Edn3)and their G-protein-coupled type A (Ednra) and type B (Ednrb...

...Ling Hou; William J. Pavan; Myung K. Shin; Heinz Arnheiter The endothelin receptor B gene ( Ednrb ) encodes a G-protein-coupled receptor that is expressed in a variety of cell types and is specifically required for the development of neural crest-derived melanocytes and enteric ganglia. In humans...

... encodes an Endothelin-1 ( Et-1 ). Like mouse and chick Et-1, suc/et-1 is expressed in a central core of arch paraxial mesoderm and in arch epithelia, both surface ectoderm and pharyngeal endoderm, but not in skeletogenic neural crest. Long before chondrogenesis, suc/et-1 mutant embryos have severe defects...

... mutation of the endothelin-1 gene ( Edn1 ), which is expressed in the epithelial layer of the branchial arches and encodes for the endothelin-1 (ET-1) signaling peptide, have a phenotype similar to CATCH-22 syndrome with aortic arch defects and craniofacial abnormalities. Here we show that the basic helix...

...Kate Reid; Ann M. Turnley; Gerald D. Maxwell; Yukiko Kurihara; Hiroki Kurihara; Perry F. Bartlett; Mark Murphy ABSTRACT Melanocytes in the skin are derived from the embryonic neural crest. Recently, mutations in endothelin 3 and the endothelin receptor B genes have been shown to result in gross...

... without a c -kit signal; pattern 3 essentially represents the hair follicles colonized by these cells. Analysis of the melanoblast distribution of ls/ls embryos that bear a loss-of-function mutation in the endothelin 3 gene suggested that endothelin 3 is required for early melanoblast differentiation...

...Raj P. Kapur; David A. Sweetser; Barbara Doggett; Joseph R. Siebert; Richard D. Palmiter ABSTRACT Mice homozygous for the piebald lethal ( s l ) mutation, which have a complete deletion of endothelin receptor-B, fail to form ganglion cells in the distal large intestine and are nearly devoid...