... eggs with clonally inherited genomes are formed from germ cells that had undergone premeiotic endoreplication, in which appropriate segregation is ensured by the formation of bivalents made from copies of identical chromosomes. We conclude that the induction of premeiotic endoreplication in reptiles...

...C. P. Unnikannan; Adriana Reuveny; Dvorah Grunberg; Talila Volk ABSTRACT DNA endoreplication has been implicated as a cell strategy for cell growth and in tissue injury. Here, we demonstrate that barrier-to-autointegration factor (BAF) represses endoreplication in Drosophila myofibers. We show...

... accumulates DNA damage, and mitotic errors ensue when cells are forced to proliferate. In conclusion, we find that wound-induced polyploidization enables tissue repair when cell division is not a viable option. Mitotic cyclin suppression is a prerequisite for endoreplication initiation, and developmental...

... past the pairing stage of meiosis. Parthenogenesis Aspidoscelis Meiosis Endoreplication Synaptonemal complex Interspecific hybridization is a common phenomenon in plants and animals ( Mallet, 2007 ). If the parental species are closely related, first generation hybrids often retain...

... synchronously with their substrate, the body wall epithelium, providing a system to study how proportionality is maintained during animal growth. Here, we show that the microRNA bantam ( ban ) ensures coordinated growth of C4da dendrites and the epithelium through regulation of epithelial endoreplication...

... cycle progression and is required for successful development. It follows that non-canonical cell cycle progression and genome instability (see Box 2 ) are linked phenomena. Interestingly, recent work from numerous systems suggests a reciprocal connection between genome instability and endoreplication...

...Remmy Kasili; Cho-Chun Huang; Jason D. Walker; L. Alice Simmons; Jing Zhou; Chris Faulk; Martin Hülskamp; John C. Larkin Endoreplication, also called endoreduplication, is a modified cell cycle in which DNA is repeatedly replicated without subsequent cell division. Endoreplication is often...

... interacts with a novel BED (BEAF and Dref) finger protein that we have termed Sunspot (Ssp). Ssp transactivates Drosophila E2F-1 ( dE2F-1 ) and PCNA expression, and positively regulates the proliferation of imaginal disc cells and the endoreplication of salivary gland cells. Wg negatively regulates...

... the entire body, most likely by regulating feeding behavior. In muscles, InR/Tor signaling, Foxo and dMyc(Diminutive) are key regulators of endoreplication, which is necessary but not sufficient to induce growth. Mechanistically, InR/Foxo signaling controls cell cycle progression by modulating dmyc...

... © 2008. 2008 APC/C Cdh1 Cyclin E Drosophila endoreplication endocycle Fzr/Cdh1 Geminin During the endocycle, also called the endoreplicative cycles, cells undergo repeated rounds of DNA replication without undergoing a cellular division. Both plants and animals use this common...

... suggested a direct role for Myc in regulating growth. We have used dm 4 , a new null allele of the Drosophila diminutive ( dm ) gene, which encodes dMyc on the X chromosome, to investigate a role for dMyc in larval endoreplicating tissues,where cellular growth and DNA replication occur in the absence...

...Jeffrey J. Esch; Margaret Chen; Mark Sanders; Matthew Hillestad; Sampson Ndkium; Brian Idelkope; James Neizer; M. David Marks Previously characterized Arabidopsis gl3 mutants have trichomes that are smaller, less branched and undergo fewer rounds of endoreplication than wild-type trichomes. A new...

... and Fig. 7 D-H for individual examples). These conclusions were confirmed by in vivo labeling studies of S phase. In larvae raised at 24°C that were between the ages of 72 and 96 hours AED, BrdU incorporation could be detected in imaginal ring cells and the endoreplicating nuclei of salivary glands...

... and imaginal disc cells, as well as the endoreplicating cells in other larval tissues. After cell cycle activation, mitotic and endoreplicating cells respond differently to the withdrawal of nutrition: mitotic cells continue to proliferate in a nutrition-independent manner, while most endoreplicating cells...

... form must be responsible for the inhibition of endoreplication. Sauer et al. (1995) demonstrated that DNA replication without cell division occurred in DmcycA mutants. Therefore, taken together these findings would suggest that Cdc2 associated with Cyclin A is likely to be an active form which...