.... ( 2021 ). Genetic and cellular contributions to liver regeneration . Cold Spring Harb. Perspect. Biol. 14 , a040832 . 10.1101/cshperspect.a040832 Lilly , M. A. and Spradling , A. C. ( 1996 ). The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S...

... including leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase 2A (PP2A). JH promotes PP2A activity via LCMT1-mediated methylation, consequently triggering FoxO dephosphorylation. Dephosphorylated FoxO binds to the upstream region of two endocycle-related genes, cell-division-cycle 2 ( Cdc2...

... regulated by prothoracicotropic hormone . Insect Mol. Biol.   14 , 563 - 571 . 10.1111/j.1365-2583.2005.00587.x Ohhara , Y. , Kobayashi , S. and Yamanaka , N. ( 2017 ). Nutrient-dependent endocycling in steroidogenic tissue dictates timing of metamorphosis in Drosophila...

...Jessica R. Von Stetina; Laura E. Frawley; Yingdee Unhavaithaya; Terry L. Orr-Weaver ABSTRACT Regulation of cell size is crucial in development. In plants and animals two cell cycle variants are employed to generate large cells by increased ploidy: the endocycle and endomitosis. The rationale behind...

... of a variety of tissues. An important example is endoreplication, in which endocycling cells alternate between G and S phase without intervening mitosis or cytokinesis, resulting in polyploidy. Although significantly different from the canonical cell cycle, endocycles use regulatory pathways that also function...

...Kevin P. Schoenfelder; Ruth A. Montague; Sarah V. Paramore; Ashley L. Lennox; Anthony P. Mahowald; Donald T. Fox The endocycle is a modified cell cycle that lacks M phase. Endocycles are well known for enabling continued growth of post-mitotic tissues. By contrast, we discovered pre-mitotic...

...Christiane Hassel; Bingqing Zhang; Michael Dixon; Brian R. Calvi The endocycle is a common developmental cell cycle variation wherein cells become polyploid through repeated genome duplication without mitosis. We previously showed that Drosophila endocycling cells repress the apoptotic cell death...

... ). Similarly, depletion of Drosophila CAF-1 leads to death in diploid cells but does not block endocycle progression ( Klapholz et al., 2009 ). In both flies and plants, CAF1 loss correlates with DNA damage, providing further evidence of endoreplication as an adaptation to genome damage. Telomere...

...Jérémy Sallé; Shelagh D. Campbell; Michel Gho; Agnès Audibert Endocycles, which are characterised by repeated rounds of DNA replication without intervening mitosis, are involved in developmental processes associated with an increase in metabolic cell activity and are part of terminal...

...Takashi Ishida; Sumiko Adachi; Mika Yoshimura; Kohei Shimizu; Masaaki Umeda; Keiko Sugimoto Amplification of genomic DNA by endoreduplication often marks the initiation of cell differentiation in animals and plants. The transition from mitotic cycles to endocycles should be developmentally...

...Karine Narbonne-Reveau; Stefania Senger; Margit Pal; Anabel Herr; Helena E. Richardson; Maki Asano; Peter Deak; Mary A. Lilly The endocycle is a commonly observed variant cell cycle in which cells undergo repeated rounds of DNA replication with no intervening mitosis. How the cell cycle machinery...

...Jianjun Sun; Wu-Min Deng During Drosophila mid-oogenesis, follicular epithelial cells switch from the mitotic cycle to the specialized endocycle in which the M phase is skipped. The switch, along with cell differentiation in follicle cells, is induced by Notch signaling. We show...

...Vidya Chandrasekaran; Steven K. Beckendorf Epithelial invagination is necessary for formation of many tubular organs,one of which is the Drosophila embryonic salivary gland. We show that actin reorganization and control of endocycle entry are crucial for normal invagination of the salivary placodes...

..., ectopic Dm myb activity can exert opposing effects on S phase: driving DNA replication and promoting proliferation in diploid cells, even when developmental signals normally dictate cell cycle arrest; but suppressing endoreduplication in endocycling cells, an effect that can be overcome by induction...

... cells. We have analyzed one such factor, the cell cycle, by studying changes in Drosophila nurse cell chromosomes throughout the 10 to 12 endocycles of oogenesis. We find that nurse cells undergo three distinct types of endocycle whose parameters are correlated with chromosome behavior. The first four...