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Keywords: Endocycle
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Journal Articles
Journal: Development
Development (2023) 150 (16): dev201896.
Published: 22 August 2023
.... ( 2021 ). Genetic and cellular contributions to liver regeneration . Cold Spring Harb. Perspect. Biol. 14 , a040832 . 10.1101/cshperspect.a040832 Lilly , M. A. and Spradling , A. C. ( 1996 ). The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188813.
Published: 23 September 2020
... including leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase 2A (PP2A). JH promotes PP2A activity via LCMT1-mediated methylation, consequently triggering FoxO dephosphorylation. Dephosphorylated FoxO binds to the upstream region of two endocycle-related genes, cell-division-cycle 2 ( Cdc2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev182568.
Published: 20 December 2019
... and developmental growth control. KDM5 Lid Transcription Prothoracic gland Endocycle Torso MAPK pathway Ecdysone Drosophila One key means by which transcription is regulated is through changes to covalent modifications that occur on nucleosomal histone proteins that comprise chromatin...
Includes: Supplementary data
Journal Articles
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Neural development
Journal: Development
Development (2018) 145 (3): dev157115.
Published: 13 February 2018
...Jessica R. Von Stetina; Laura E. Frawley; Yingdee Unhavaithaya; Terry L. Orr-Weaver ABSTRACT Regulation of cell size is crucial in development. In plants and animals two cell cycle variants are employed to generate large cells by increased ploidy: the endocycle and endomitosis. The rationale behind...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4288–4298.
Published: 15 December 2015
... of a variety of tissues. An important example is endoreplication, in which endocycling cells alternate between G and S phase without intervening mitosis or cytokinesis, resulting in polyploidy. Although significantly different from the canonical cell cycle, endocycles use regulatory pathways that also function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3551–3560.
Published: 15 September 2014
...Kevin P. Schoenfelder; Ruth A. Montague; Sarah V. Paramore; Ashley L. Lennox; Anthony P. Mahowald; Donald T. Fox The endocycle is a modified cell cycle that lacks M phase. Endocycles are well known for enabling continued growth of post-mitotic tissues. By contrast, we discovered pre-mitotic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (1): 112–123.
Published: 1 January 2014
...Christiane Hassel; Bingqing Zhang; Michael Dixon; Brian R. Calvi The endocycle is a common developmental cell cycle variation wherein cells become polyploid through repeated genome duplication without mitosis. We previously showed that Drosophila endocycling cells repress the apoptotic cell death...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: Primer Series
Development (2013) 140 (1): 3–12.
Published: 1 January 2013
... ). Similarly, depletion of Drosophila CAF-1 leads to death in diploid cells but does not block endocycle progression ( Klapholz et al., 2009 ). In both flies and plants, CAF1 loss correlates with DNA damage, providing further evidence of endoreplication as an adaptation to genome damage. Telomere...
Journal Articles
Journal: Development
Development (2012) 139 (3): 547–557.
Published: 1 February 2012
...Jérémy Sallé; Shelagh D. Campbell; Michel Gho; Agnès Audibert Endocycles, which are characterised by repeated rounds of DNA replication without intervening mitosis, are involved in developmental processes associated with an increase in metabolic cell activity and are part of terminal...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (1): 63–71.
Published: 1 January 2010
...Takashi Ishida; Sumiko Adachi; Mika Yoshimura; Kohei Shimizu; Masaaki Umeda; Keiko Sugimoto Amplification of genomic DNA by endoreduplication often marks the initiation of cell differentiation in animals and plants. The transition from mitotic cycles to endocycles should be developmentally...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1451–1461.
Published: 15 April 2008
...Karine Narbonne-Reveau; Stefania Senger; Margit Pal; Anabel Herr; Helena E. Richardson; Maki Asano; Peter Deak; Mary A. Lilly The endocycle is a commonly observed variant cell cycle in which cells undergo repeated rounds of DNA replication with no intervening mitosis. How the cell cycle machinery...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (15): 3515–3524.
Published: 1 August 2005
...Vidya Chandrasekaran; Steven K. Beckendorf Epithelial invagination is necessary for formation of many tubular organs,one of which is the Drosophila embryonic salivary gland. We show that actin reorganization and control of endocycle entry are crucial for normal invagination of the salivary placodes...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4497–4507.
Published: 1 October 2002
..., ectopic Dm myb activity can exert opposing effects on S phase: driving DNA replication and promoting proliferation in diploid cells, even when developmental signals normally dictate cell cycle arrest; but suppressing endoreduplication in endocycling cells, an effect that can be overcome by induction...
Journal Articles
Journal: Development
Development (1999) 126 (2): 293–303.
Published: 15 January 1999
... cells. We have analyzed one such factor, the cell cycle, by studying changes in Drosophila nurse cell chromosomes throughout the 10 to 12 endocycles of oogenesis. We find that nurse cells undergo three distinct types of endocycle whose parameters are correlated with chromosome behavior. The first four...