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Keywords: Endocrine
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Journal Articles
Journal: Development
Development (2019) 146 (22): dev171405.
Published: 21 November 2019
... Neural plate border Neurulation Otx FGF Placode Pineal Endocrine Zebrafish Chick * Present address: Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK. ‡ Present address: Institut Pasteur, 75015 Paris, France. § Author for correspondence ( clemens.kiecker@kcl.ac.uk...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev165480.
Published: 15 August 2018
... cells present in the human fetal pancreas and their lineage relationships, we developed strategies to isolate pancreatic progenitors, endocrine progenitors and endocrine cells. Transcriptome analysis of the individual populations revealed a large degree of conservation among vertebrates in the drivers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 101–112.
Published: 01 January 2016
...) population is specified, giving rise to three important lineages: acinar, ductal and endocrine. Pdx1 is a transcription factor required for pancreas development and lineage specification; however, few Pdx1 targets that regulate pancreatogenesis have been identified. We find that pancreatic defects in Pdx1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 858–870.
Published: 01 March 2015
... left-right asymmetry randomization and renal cysts. Here, we show that BICC1 is also expressed in both the pancreatic progenitor cells that line the ducts during development, and in the ducts after birth, but not in differentiated endocrine or acinar cells. Genetic inactivation of Bicc1 leads to ductal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1557–1567.
Published: 01 May 2012
... remains unclear. Here, using single-cell genetic analyses and a new transgenic system that allows dynamic assessment of Notch signaling, we address how discrete levels of Notch signaling regulate the behavior of endocrine progenitors in the zebrafish intrapancreatic duct. We find that these progenitors...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1447–1456.
Published: 15 April 2012
...David E. Metzger; Malgorzata Gasperowicz; Florian Otto; James C. Cross; Gerard Gradwohl; Kenneth S. Zaret Pancreatic β-cells arise from Ngn3 + endocrine progenitors within the trunk epithelium of the embryonic pancreas. The emergence of endocrine cells requires E-cadherin downregulation, but the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 631–640.
Published: 15 February 2011
... reduction of β-cells, leading to some ambiguity as to the role of Hh during pancreas development and whether its function has completely diverged between species. Here, we have employed genetic and pharmacological manipulations to temporally delineate the role of Hh in zebrafish endocrine pancreas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (2): 203–212.
Published: 15 January 2010
... uncharacterized winged helix transcription factor Rfx6. Rfx6 is initially expressed broadly in the gut endoderm, notably in Pdx1-positive cells in the developing pancreatic buds, and then becomes progressively restricted to the endocrine lineage, suggesting a dual function in both endoderm development and islet...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2491–2500.
Published: 01 July 2007
...Shelley B. Nelson; Ashleigh E. Schaffer; Maike Sander Despite much progress in identifying transcriptional regulators that control the specification of the different pancreatic endocrine cell types,the spatiotemporal aspects of endocrine subtype specification have remained largely elusive. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (13): 3139–3149.
Published: 01 July 2005
... partially compensates for NKX6.1 function. Surprisingly, our analysis of Nkx6 compound mutant mice revealed a previously unrecognized requirement for NKX6 activity in α-cell formation. This finding suggests a more general role for NKX6 factors in endocrine cell differentiation than formerly suggested...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (1): 165–179.
Published: 01 January 2004
...Guoqiang Gu; James M. Wells; David Dombkowski; Fred Preffer; Bruce Aronow; Douglas A. Melton To define genetic pathways that regulate development of the endocrine pancreas, we generated transcriptional profiles of enriched cells isolated from four biologically significant stages of endocrine...
Includes: Supplementary data