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Keywords: Endochondral bone growth
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Journal Articles
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
Available to PurchaseKai Yu, Jingsong Xu, Zhonghao Liu, Drazen Sosic, Jiansu Shao, Eric N. Olson, Dwight A. Towler, David M. Ornitz
Journal:
Development
Development (2003) 130 (13): 3063–3074.
Published: 1 July 2003
... ; Li et al., 1999 ; Naski et al., 1998 ; Segev et al., 2000 ; Wang et al., 1999). In contrast, mice lacking Fgfr3 exhibit skeletal overgrowth(Colvin et al., 1996). Together, these data establish Fgfr3 as a negative regulator of endochondral bone growth. The majority of missense mutations...
