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Keywords: En1
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Journal Articles
Journal: Development
Development (2007) 134 (12): 2325–2335.
Published: 15 June 2007
... are candidate regulators of this process in the dorsal midbrain (tectum) and anterior hindbrain (cerebellum). En1 mutants lack most of the tectum and cerebellum and die at birth, whereas En2 mutants are viable with a smaller cerebellum and foliation defects. Our previous studies indicated that the difference...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 63–74.
Published: 1 January 2006
... as critical regulators of this process. Here, we show that the homeoprotein engrailed 1(EN1) is expressed during embryonic and perinatal craniofacial bone development, where it localizes to the skeletogenic mesenchyme, and,subsequently, to calvarial osteoblasts and osteoprogenitors. Mice lacking En1 exhibit...
Journal Articles
Journal: Development
Development (2002) 129 (20): 4763–4772.
Published: 15 October 2002
... or permissive environment produced by the midline tissues or/and a repellent or inadequate environment by the lateral tissues. By contrast, the dorsolateral dermal cells just delaminate from the surface of the intervening space, which expresses En1. Excision of the axial organs or the ectoderm, and grafting...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (11): 2357–2365.
Published: 1 June 2000
...Eiji Matsunaga; Isato Araki; Harukazu Nakamura ABSTRACT Transcriptional factors and signaling molecules are responsible for regionalization of the central nervous system. In the early stage of neural development, Pax6 is expressed in the prosencephalon, while En1 and Pax2 are expressed...
Journal Articles
Journal: Development
Development (1999) 126 (6): 1189–1200.
Published: 15 March 1999
.... These morphogenetic effects were apparently due to FGF8-mediated changes in gene expression in the vicinity of the bead, including a repressive effect on Otx2 and an inductive effect on En1, Fgf8 and Wnt1 expression. The ectopic Fgf8 and Wnt1 expression domains formed nearly complete concentric rings around the FGF8...
Journal Articles
Journal: Development
Development (1999) 126 (5): 945–959.
Published: 1 March 1999
... factors in regulating these processes in the avian embryo. We show that Fgf4 is expressed in the notochord anterior to Hensen’s node before transcripts for the earliest molecular marker of midbrain tissue in the avian embryo, En1 , are detected. The presence of notochord is required for the expression...
Journal Articles
Journal: Development
Development (1998) 125 (22): 4521–4530.
Published: 15 November 1998
...Mark C. Hanks; Cynthia A. Loomis; Esther Harris; Chung-Xiang Tong; Lynn Anson-Cartwright; Anna Auerbach; Alexandra Joyner ABSTRACT The Engrailed-1 gene, En1 , a murine homologue of the Drosophila homeobox gene engrailed ( en ), is required for midbrain and cerebellum development and dorsal/ventral...
Journal Articles
Journal Articles