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Keywords: Embryonic stem cells
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Journal: Development
Development (2023) 150 (6): dev201177.
Published: 15 March 2023
..., but the global translational dynamics are still ambiguous. Here, we differentiate human embryonic stem cells (ESCs) into neural progenitor cells (NPCs) with high efficiency and perform ribosome sequencing and RNA sequencing on both ESCs and NPCs. Data analysis reveals that translational controls engage in many...
Includes: Supplementary data
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Journal: Development
Development (2022) 149 (22): dev200845.
Published: 28 November 2022
...Andrew Keniry; Natasha Jansz; Peter F. Hickey; Kelsey A. Breslin; Megan Iminitoff; Tamara Beck; Quentin Gouil; Matthew E. Ritchie; Marnie E. Blewitt ABSTRACT Female mouse embryonic stem cells (mESCs) present differently from male mESCs in several fundamental ways; however, complications...
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Journal: Development
Development (2021) 148 (17): dev199604.
Published: 10 September 2021
...Nicola Festuccia; Nick Owens; Almira Chervova; Agnès Dubois; Pablo Navarro ABSTRACT The maintenance of pluripotency in mouse embryonic stem cells (ESCs) is governed by the action of an interconnected network of transcription factors. Among them, only Oct4 and Sox2 have been shown to be strictly...
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Human development
Journal: Development
Development (2020) 147 (14): dev190629.
Published: 17 July 2020
... the mechanisms behind cell fate specification, tissue shape changes and their mutual regulation generates an integrated understanding of embryogenesis. Recent technological advances now make this possible in the human embryo. Human embryo Morphogenesis Cell fate Embryonic stem cells Aneuploidy...
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Journal: Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
... be cultured indefinitely in vitro under defined conditions. These cells, termed embryonic stem cells (ESCs), enable the study of mechanisms involved in the earliest fate decisions in embryonic development. During early differentiation both in vivo and in vitro , ESCs undergo molecular and morphogenetic...
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Journal: Development
Development (2019) 146 (10): dev168187.
Published: 20 May 2019
.... These progenitors, called neural mesodermal progenitors (NMPs), are identified as cells that co-express Sox2 and T/ brachyury, a criterion used to derive NMP-like cells from embryonic stem cells in vitro . However, unlike embryonic NMPs, these progenitors do not self-renew. Here, we find that the protocols...
Includes: Supplementary data
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Journal: Development
Development (2018) 145 (22): dev168617.
Published: 21 November 2018
... blasticidin and 1 μg/ml puromycin for 1 week. No additional authentication other than that provided by Cell Biolabs was performed. The Hb9 ::GFP embryonic stem cell line was derived from 3.5 days post-coitum embryos from a 2-month-old Hb9 ::GFP C57Bl/6 female. This cell line was validated using PCR...
Includes: Supplementary data
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Journal: Development
Development (2018) 145 (20): dev170209.
Published: 17 October 2018
..., OCT4 and PRDM14, in mouse embryonic stem cells, epiblast-like cells and primordial germ cell-like cells (PGCLCs). PGCLCs are an important system for elucidating primordial germ cell development in mice. We monitored PRDM14 binding during the specification of PGCLCs, identifying direct targets of PRDM14...
Includes: Supplementary data
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Journal: Development
Development (2018) 145 (8): dev158360.
Published: 13 April 2018
... largely been ignored. However, recent advances, such as the genomic profiling of embryonic stem cells, have uncovered the significance and mechanisms of p53 functions in mammalian cell differentiation and development. As we review here, these recent findings reveal roles that complement the well...