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Keywords: Embryonic stem cells
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Journal Articles
Journal: Development
Development (2022) 149 (20): dev192310.
Published: 22 August 2022
.... Here, we create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn). We trigger naive mouse embryonic stem cells to form a blastocyst-stage niche of Epi-like cells and XEn-like cells (3D, hydrogel free and serum free). Once...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2022) 149 (12): dev200527.
Published: 20 June 2022
..., we demonstrated that homozygous knockout of Hbxip leads to embryonic lethality, with retarded growth around E7.5, and that depletion of Hbxip compromises the self-renewal of embryonic stem cells (ESCs), with reduced expression of pluripotency genes, reduced cell proliferation and decreased colony...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199901.
Published: 7 December 2021
..., stable and continuously expandable pluripotent stem cells related to embryonic disc epiblast from embryos of pig, sheep and cow. Embryonic stem cells Epiblast Mammalian embryo Nuclear transfer Pluripotency Self-renewal Biotechnology and Biological Sciences Research Council http...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199926.
Published: 5 November 2021
... and primitive endoderm-like cells in mouse embryonic stem cell cultures emerges at the population level through cell-cell communication via a short-range fibroblast growth factor 4 (FGF4) signal. We characterize the molecular and dynamical properties of the communication mechanism and show how it controls both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199604.
Published: 10 September 2021
...Nicola Festuccia; Nick Owens; Almira Chervova; Agnès Dubois; Pablo Navarro ABSTRACT The maintenance of pluripotency in mouse embryonic stem cells (ESCs) is governed by the action of an interconnected network of transcription factors. Among them, only Oct4 and Sox2 have been shown to be strictly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199477.
Published: 6 September 2021
... of STAT3 inside mitochondria requires Y705 phosphorylation by Jak, whereas its mitochondrial transcriptional activity, as well as its effect on proliferation, depends on the MAPK target S727. These data were confirmed using mouse embryonic stem cells: although the Y705-mutated STAT3 cannot enter...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev188516.
Published: 4 December 2020
.... 17 1 2020 27 10 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: SUV420H2 regulation of H4K20me3-marked heterochromatin controls the chromatin structure of embryonic stem cells, where loss of SUV420H2 results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev185264.
Published: 24 August 2020
...Zhenhua Zhu; Yan Zhang; Xiaoxiao Wang; Xiaohu Wang; Shou-Dong Ye ABSTRACT The identification of novel mechanisms to maintain embryonic stem cell (ESC) pluripotency is of crucial importance, because the currently used culture conditions are not suitable for ESCs from all species. In this study, we...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (14): dev190629.
Published: 17 July 2020
... , A. and Nichols , J. ( 2016 ). Selection and dynamics of embryonic stem cell integration into early mouse embryos . Development   143 , 24 - 34 . 10.1242/dev.124602 Alikani , M. ( 2005 ). Epithelial cadherin distribution in abnormal human pre-implantation embryos . Hum Reprod   20 , 3369...
Journal Articles
Journal: Development
Development (2019) 146 (24): dev180620.
Published: 16 December 2019
...Madeleine Linneberg-Agerholm; Yan Fung Wong; Jose Alejandro Romero Herrera; Rita S. Monteiro; Kathryn G. V. Anderson; Joshua M. Brickman ABSTRACT Embryonic stem cells (ESCs) exist in at least two states that transcriptionally resemble different stages of embryonic development. Naïve ESCs resemble...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev164772.
Published: 25 September 2019
... pluripotency. Epigenetics Pluripotency Transcriptional regulation Embryonic stem cells Epiblast-like cells Mouse Cell-fate transitions are ultimately driven by changes in gene expression. Gene expression is regulated by the binding of transcription factors (TFs) to specific and conserved DNA...
Journal Articles
Journal: Development
Development (2019) 146 (10): dev168187.
Published: 20 May 2019
.... These progenitors, called neural mesodermal progenitors (NMPs), are identified as cells that co-express Sox2 and T/ brachyury, a criterion used to derive NMP-like cells from embryonic stem cells in vitro . However, unlike embryonic NMPs, these progenitors do not self-renew. Here, we find that the protocols...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev173146.
Published: 26 March 2019
.... , et al. ( 2017 ). One-step generation of conditional and reversible gene knockouts . Nat. Methods   14 , 287 - 289 . 10.1038/nmeth.4156 Batlle-Morera , L. , Smith , A. and Nichols , J. ( 2008 ). Parameters influencing derivation of embryonic stem cells from murine embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (22): dev168617.
Published: 21 November 2018
...., 2011 ; Wichterle et al., 2002 ). Currently, there is no consensus concerning whether one of these approaches more accurately produces differentiated cell types of interest. There are few comparisons of cells produced by both lineage conversion and embryonic stem cell (ESC)- or iPSC-directed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev170209.
Published: 17 October 2018
..., OCT4 and PRDM14, in mouse embryonic stem cells, epiblast-like cells and primordial germ cell-like cells (PGCLCs). PGCLCs are an important system for elucidating primordial germ cell development in mice. We monitored PRDM14 binding during the specification of PGCLCs, identifying direct targets of PRDM14...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev162404.
Published: 30 May 2018
...Mariko Yamane; Satoshi Ohtsuka; Kumi Matsuura; Akira Nakamura; Hitoshi Niwa ABSTRACT Krüppel-like factors (Klfs) have a pivotal role in maintaining self-renewal of mouse embryonic stem cells (mESCs). The functions of three Klf family members (Klf2, Klf4 and Klf5) have been identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev158360.
Published: 13 April 2018
... largely been ignored. However, recent advances, such as the genomic profiling of embryonic stem cells, have uncovered the significance and mechanisms of p53 functions in mammalian cell differentiation and development. As we review here, these recent findings reveal roles that complement the well...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev157420.
Published: 14 March 2018
.... Inhibition of GSK3 mimics activation of the Wnt signal. Definitive endoderm. A cell lineage of the post-implantation embryo after gastrulation. Definitive endoderm gives rise to embryonic endoderm cell types. Embryonic stem cells (ESCs). Pluripotent stem cells (PSCs) derived from blastocyst stage...
Journal Articles
Journal: Development
Development (2017) 144 (12): 2104–2122.
Published: 15 June 2017
... dystrophy Pluripotent stem cells Embryonic stem cells iPS cells With more than 600 individual muscles, skeletal muscle represents the largest tissue mass of the body and is essential for motion and support. Skeletal muscles are distinct from both cardiac and smooth muscles in that they can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 567–579.
Published: 15 February 2017
... demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exit of ESC pluripotency. Here, we reveal that Jmjd2c facilitates this process by stabilising the assembly of mediator-cohesin complexes at lineage-specific enhancers...
Includes: Supplementary data